Results 41 to 50 of about 7,985,151 (196)

Does uncertainty in variability in relative biological effectiveness affect patient treatment in proton therapy? [PDF]

, 2021
Clinical treatment with protons uses the concept of relative biological effectiveness (RBE) to convert the absorbed dose into an RBE-weighted dose that equals the dose for radiotherapy with photons causing the same biological effect. Currently, in proton
Whitfield, Gillian A, Bauer, Julia, Pawelke, Jörg, Whitfield, Gillian A., Krause, Mechthild, Lühr, Armin, Karger, Christian, Sørensen, Brita S., Dasu, Alexandru,, Schwarz, Marco, Wagenaar, Dirk; id_orcid, Underwood, Tracy, Burnet, Neil G, Karger, Christian P, Underwood, Tracy S A, Dasu, Alexandru, Høyer, Morten, Wagenaar, Dirk, Burnet, Neil, Sørensen, Brita S, Høyer, M., Sørensen, B. S., Karger, C. P., Dasu, A., Pawelke, J., Bauer, J., Schwarz, M., Krause, M., Lühr, A., Wagenaar, D., Armin Lühr, Morten Høyer, Marco Schwarz, Christian P. Karger, Alexandru Dasu, Dirk Wagenaar, Brita S. Sørensen, Julia Bauer, Tracy S.A. Underwood, Neil G. Burnet, Jörg Pawelke, Gillian A. Whitfield, Mechthild Krause   +42 more
core   +1 more source

The relative biological effectiveness of antiprotons

, 2016
Aside from the enhancement of physical dose deposited by antiprotons annihilating in tissue-like material compared to protons of the same range a further increase of biological effective dose has been demonstrated. This enhancement can be expressed in an
Knudsen, Helge, Boll, Rebecca, Petersen, Jørgen B, CACCIA, MASSIMO, Alsner, Jan, Straße, Tina, Singers Sørensen, Brita, Holzscheiter, Michael H, Bassler, Niels, Overgaard, Jens, Maggiore, Carl, Sellner, Stefan   +11 more
core   +1 more source

Mixed- and multi-relative biological effectiveness model simultaneous optimization in carbon ion radiotherapy: A proof-of-concept

Physics and Imaging in Radiation Oncology
Background and purpose: In carbon ion radiotherapy (CIRT), different relative biological effectiveness (RBE) models have been used for calculating RBE-weighted dose (DRBE).
Aaron Paul Osburg, Peter Lysakovski, Giuseppe Magro, Semi Harrabi, Thomas Haberer, Amir Abdollahi, Jürgen Debus, Thomas Tessonnier, Andrea Mairani   +8 more
doaj   +1 more source

Physical characteristics at the turnover-points of relative biological effect (RBE) with linear energy transfer (LET) [PDF]

Physics in Medicine & Biology, 2019
Abstract This paper considers the kinematic physical characteristics of ionic beams for maximum relative bio-effectiveness (RBE). RBE studies, based on heterogenous cell survival studies at different laboratories and linear energy transfer (LET) conditions for proton, helium, carbon, neon and ...
Jones, B, Hill, MA
openaire   +3 more sources

Comparative Evaluation of Chelator‐Conjugated Peptides for Lead‐Labeled SSTR2‐Targeted Theranostics: Integrated Computational Modeling and Preclinical Validation

Advanced Science, EarlyView.
The study integrates density functional theory with radiochemical and biological validation to compare DOTA‐, PSC‐, and DOTAM‐based chelator‐conjugates for 203Pb/212Pb theranostic applications. Distinct differences in metal coordination, electrostatic properties, conformational flexibility, cellular uptake, biodistribution, and dosimetry are identified
Jeongyun Kim, Na Yeon Han, Ayman Muzammal, Jae Hun Ahn, Changkeun Im, Sujin Kim, Sairan Eom, Choong Mo Kang, Ku Kang, Yong Jin Lee, Kyo Chul Lee, Michael K. Schultz, Dongyoul Lee   +12 more
wiley   +1 more source

Selective Cell‐Repellent 3D Scaffold Platform for Proton Radiobiology

Advanced NanoBiomed Research, EarlyView.
A selective cell‐repellent 3D scaffold platform is developed to minimize unwanted 2D cell populations surrounding engineered cell microenvironments. The approach is based on the combination of Lipidure coatings with two‐photon polymerized scaffolds and enables specific characterization of glioblastoma cells’ response to proton irradiation.
Novinda S. Pertiwi, Qais Akolawala, Rob van den Akker, Anggraeini Puspitasari‐Kokko, Henri H. Versteeg, Araci M. R. Rondon, Angelo Accardo   +6 more
wiley   +1 more source

Cumulative distribution function (CDF) versus the maximum relative biological effectiveness (RBE) factor, RBE_max or RBE_γAcute based on experimental data from Table 2, and non-linear regression fits of the 3 parameter logistic equation to these data.

, 2015
Cumulative distribution function (CDF) versus the maximum relative biological effectiveness (RBE) factor, RBEmax or RBEγAcute based on experimental data from Table 2, and non-linear regression fits of the 3 parameter logistic equation to these data.
Francis A. Cucinotta (135575)
core   +1 more source

Tooth histotype and enameloid microstructure of Priohybodus arambourgi d'Erasmo, 1960 (Elasmobranchii: Hybodontiformes) from the Late Jurassic of northeastern Brazil

The Anatomical Record, EarlyView.
Abstract Sharks possess varied diets and different prey capture mechanisms. As a result, the group exhibits a significant diversity in dental morphology, also reflecting the internal structures of the teeth. Internal dental anatomy points to the existence of three histotypes in elasmobranch phylogeny: orthodont, osteodont, and pseudoosteodont ...
Kelly Roberta da Silva, Valéria Gallo, Estevan Eltink   +2 more
wiley   +1 more source

RBE values determined for 12C- and 16O-irradiation of HepG2, Hep3B, HuH7, and PLC cells.

, 2014
RBE Relative Biological Effectiveness, ph photons.RBE values determined for 12C- and 16O-irradiation of HepG2, Hep3B, HuH7, and PLC cells.
Klaus-Josef Weber (241705), Daniel Habermehl (14826), Thomas Haberer (668419), Jürgen Debus (21664), Stephanie E. Combs (668420), Katarina Ilicic (668414), Sarah Dehne (668415), Stephan Brons (668418), Stefan Rieken (668416), Lena Orschiedt (668417)   +9 more
core   +1 more source

Brachial Plexopathy in Head and Neck Cancer Potentially Related to LET-Dependent RBE

Biophysica
Proton beam therapy for head and neck cancers traditionally employs a fixed relative biological effectiveness (RBE) of 1.1, which may underestimate actual biological effects in critical structures.
Abanob Hanna, Anthony Casper, Roi Dagan, Hardev S. Grewal, Jiyeon Park, Eric D. Brooks, Erik Traneus, Lars Glimelius, Perry B. Johnson, Mohammad Saki, Yawei Zhang, Twyla R. Willoughby, Julie A. Bradley, Jackson Browne, Mark E. Artz   +14 more
doaj   +1 more source