Results 41 to 50 of about 9,817 (201)

Mixed- and multi-relative biological effectiveness model simultaneous optimization in carbon ion radiotherapy: A proof-of-concept

Physics and Imaging in Radiation Oncology
Background and purpose: In carbon ion radiotherapy (CIRT), different relative biological effectiveness (RBE) models have been used for calculating RBE-weighted dose (DRBE).
Aaron Paul Osburg, Peter Lysakovski, Giuseppe Magro, Semi Harrabi, Thomas Haberer, Amir Abdollahi, Jürgen Debus, Thomas Tessonnier, Andrea Mairani   +8 more
doaj   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Physical characteristics at the turnover-points of relative biological effect (RBE) with linear energy transfer (LET) [PDF]

Physics in Medicine & Biology, 2019
This paper considers the kinematic physical characteristics of ionic beams for maximum relative bio-effectiveness (RBE). RBE studies, based on heterogenous cell survival studies at different laboratories and linear energy transfer (LET) conditions for proton, helium, carbon, neon and argon ions, have been further analysed to determine the LETU values ...
Jones, B, Hill, MA
openaire   +3 more sources

Patient‐Derived 3D‐Bioprinted Intrahepatic Cholangiocarcinoma Models Recapitulate Tumor Autologous Traits and Predict Personalized Adjuvant Therapy

Advanced Science, EarlyView.
Leveraging 3D bioprinting, this study establishes patient‐derived in vitro models of intrahepatic cholangiocarcinoma. These models faithfully recapitulate the histopathology, molecular profiles, and genomic characteristics of the original patient tumors.
Yuce Lu, Liwei Du, Minghao Sun, Kai Zhang, Mingchang Pang, Shangze Jiang, Jiaxun Dong, Xiyue Liu, Bao Jin, Fu Xu, Hang Sun, Jiangang Zhang, Huiyu Yang, Xiaobo Yang, Xin Lu, Yiyao Xu, Haitao Zhao, Shunda Du, Xinting Sang, Yongchang Zheng, Lei Zhang, Xueshuai Wan, Huayu Yang, Yilei Mao   +23 more
wiley   +1 more source

Estimation of biological effect of Cu-64 radiopharmaceuticals with Geant4-DNA simulation

Scientific Reports, 2022
The aim of this work is to estimate the biological effect of targeted radionuclide therapy using Cu-64, which is a well-known Auger electron emitter. To do so, we evaluate the absorbed dose of emitted particles from Cu-64 using the Geant4-DNA Monte Carlo
Tamon Kusumoto, Kentaro Baba, Sumitaka Hasegawa, Quentin Raffy, Satoshi Kodaira   +4 more
doaj   +1 more source

Bacterial Pigments as Potential Antitumor Agents Against Gastrointestinal Cancers: A Comprehensive Systematic Review

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara, Ricardo F. S. Pereira, Carla C. C. R. de Carvalho, Jose Prados, Consolación Melguizo, Raul Ortiz   +5 more
wiley   +1 more source

Brachial Plexopathy in Head and Neck Cancer Potentially Related to LET-Dependent RBE

Biophysica
Proton beam therapy for head and neck cancers traditionally employs a fixed relative biological effectiveness (RBE) of 1.1, which may underestimate actual biological effects in critical structures.
Abanob Hanna, Anthony Casper, Roi Dagan, Hardev S. Grewal, Jiyeon Park, Eric D. Brooks, Erik Traneus, Lars Glimelius, Perry B. Johnson, Mohammad Saki, Yawei Zhang, Twyla R. Willoughby, Julie A. Bradley, Jackson Browne, Mark E. Artz   +14 more
doaj   +1 more source

Validation of the physical and RBE-weighted dose estimator based on PHITS coupled with a microdosimetric kinetic model for proton therapy [PDF]

, 2017
The microdosimetric kinetic model (MKM) is widely used for estimating relative biological effectiveness (RBE)-weighted doses for various radiotherapies because it can determine the surviving fraction of irradiated cells based on only the lineal energy ...
Koketsu Junichi, Kumada Hiroaki, Sakae Takeji, Sakurai Hideyuki, Sato Tatsuhiko, Takada Kenta, Takei Hideyuki, 榮 武二, 櫻井 英幸, 熊田 博明, 髙田 健太   +10 more
core   +2 more sources

Hypofractionated Spot Scanning Proton Therapy for Head and Neck Mucosal Melanoma: A Retrospective Analysis With Quality‐of‐Life Outcome

Head &Neck, EarlyView.
ABSTRACT Objective To evaluate clinical outcomes and quality of life (QOL) following hypofractionated spot‐scanning proton therapy (SSPT) for head and neck malignant mucosal melanoma (HNMM). Methods This retrospective study included 39 patients treated with SSPT (60–64 Gy[RBE] in 15–16 fractions) between 2013 and 2023.
Koichiro Nakajima, Hiromitsu Iwata, Gaku Takano, Daiki Kojima, Yukiko Hattori, Yusuke Tsuzuki, Shuou Sudo, Kensuke Hayashi, Toshiyuki Toshito, Hideo Fukano, Hiroyuki Ogino, Akio Hiwatashi   +11 more
wiley   +1 more source

Recommendations for reporting and evaluating proton therapy beyond dose and constant relative biological effectiveness

Physics and Imaging in Radiation Oncology
Background and purpose: In proton therapy, a relative biological effectiveness (RBE) of 1.1 is used to convert proton dose into an equivalent photon dose.
Armin Lühr, Dirk Wagenaar, Daniëlle B.P. Eekers, Lars Glimelius, Steven J.M. Habraken, Semi Harrabi, Miranda C.A. Kramer, Ranald I. Mackay, Ana Vaniqui, Alexandru Dasu, Damien C. Weber   +10 more
doaj   +1 more source