Results 31 to 40 of about 1,064,021 (213)

The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological preconditioning [PDF]

, 2006
Includes bibliographical references (leaves 150-177).Ischemic preconditioning is a protective mechanism whereby repetitive transient ischaemia confer protection against the subsequent prolonged lethal ischaemia that is observed during myocardial ...
Suleman, Naushaad
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Safety and Feasibility of Remote Limb Ischemic Preconditioning in Patients with Unilateral Middle Cerebral Artery Stenosis and Healthy Volunteers

Cell Transplantation, 2015
Previous studies have indicated a neuroprotective effect of remote limb ischemic preconditioning. The aim of the present study was to assess whether upper arm ischemic preconditioning is feasible and safe in patients with unilateral middle cerebral ...
Sijie Li, Chun Ma, Guo Shao, Fatema Esmail, Yang Hua, Lingyun Jia, Jian Qin, Changhong Ren, Yumin Luo, Yuchun Ding, Cesario V. Borlongan, Xunming Ji   +11 more
doaj   +1 more source

The challenge of translating ischemic conditioning from animal models to humans: the role of comorbidities

Disease Models & Mechanisms, 2014
Following a period of ischemia (local restriction of blood supply to a tissue), the restoration of blood supply to the affected area causes significant tissue damage.
Kieran McCafferty, Suzanne Forbes, Christoph Thiemermann, Muhammad M. Yaqoob   +3 more
doaj   +1 more source

Review Cerebral Ischemic Tolerance and Preconditioning: Methods, Mechanisms, Clinical Applications, and Challenges

Frontiers in Neurology, 2020
Stroke is one of the leading causes of morbidity and mortality worldwide, and it is increasing in prevalence. The limited therapeutic window and potential severe side effects prevent the widespread clinical application of the venous injection of ...
Yulei Hao, Meiying Xin, Liangshu Feng, Xinyu Wang, Xu Wang, Di Ma, Jiachun Feng   +6 more
doaj   +1 more source

Association between clinical presentations before myocardial infarction and coronary mortality: a prospective population-based study using linked electronic records. [PDF]

, 2014
BACKGROUND: Ischaemia in different arterial territories before acute myocardial infarction (AMI) may influence post-AMI outcomes. No studies have evaluated prospectively collected information on ischaemia and its effect on short- and long-term coronary ...
Hemingway, Harry, Herrett, Emily, Smeeth, Liam, Bhaskaran, Krishnan, Denaxas, Spiros, Timmis, Adam   +5 more
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Immune mechanisms in cerebral ischemic tolerance

Frontiers in Neuroscience, 2014
Stressor-induced tolerance is a central mechanism in the response of bacteria, plants, and animals to potentially harmful environmental challenges.
Lidia eGarcia-Bonilla, Corinne eBenakis, Jamie eMoore, Costantino eIadecola, Josef eAnrather   +4 more
doaj   +1 more source

Effect of Staged Preconditioning on BiochemicalMarkers in the Patients Undergoing Coronary Artery Bypass Grafting [PDF]

The present study has investigated the effectiveness of staged-preconditioning, in both remote and target organs. After IP the myocardial release of the biochemicalmarkers including, creatine phosphokinase (CPK), cardiac creatine kinase (CK-MB ...
حسینیان, عدالت, دوستکامی, حسین, جعفری, ناصر, باباپور, بهزاد, محمدزاده, علیرضا, حسن پور, محمد   +5 more
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Acute effects of remote ischemic preconditioning on cutaneous microcirculation - a controlled prospective cohort study

BMC Surgery, 2011
Background Therapeutic strategies aiming to reduce ischemia/reperfusion injury by conditioning tissue tolerance against ischemia appear attractive not only from a scientific perspective, but also in clinics. Although previous studies indicate that remote
Kraemer Robert, Lorenzen Johan, Kabbani Mohammad, Herold Christian, Busche Marc, Vogt Peter M, Knobloch Karsten   +6 more
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Neuroprotective and nephroprotective effects of remote postconditioning: Prospects for clinical use [PDF]

Терапевтический архив, 2016
The results of experimental and clinical studies strongly suggest that remote ischemic preconditioning (RIP) has no neuroprotective effect during cardiac surgery performed under extracorporeal circulation.
L N Maslov, S Yu Tsibulnikov, A V Tsepokina, M V Khutornaya, A G Kutikhin, M R Tsibulnikova, M V Basalay, A G Mrochek   +7 more
doaj   +1 more source

Pretreatment with remote ischemic conditioning attenuates testicular damage after testicular ischemia and reperfusion injury in rats.

PLoS ONE, 2023
Testicular torsion is a urological emergency. However, surgical detorsion of the torsed spermatic cord can cause testicular reperfusion injury. Although remote ischemic preconditioning (RIPC) has been convincingly shown to protect organs against ischemia/
Jiaxue Li, Zhibing Yan, Qifeng Wang, Shichao Wei, Quanhua Liu, Ting Liu, Zhaoyang Hu   +6 more
doaj   +1 more source