Results 71 to 80 of about 1,064,021 (213)

Plasma exosomal miR‐339‐3p promotes myocardial remodeling in chronic heart failure by regulating USP25‐mediated DDX58 deubiquitination

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
In the patients of chronic heart failure (HF), miR‐339‐3p derived from plasma exosomes can target ubiquitin‐specific protease 25, inhibiting its K48‐linked deubiquitination modification of DDX58, leading to increased ubiquitination and degradation of DDX58.
Guoqiang Jing, Ting Xu, Yuhong Ma
wiley   +1 more source

Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection [PDF]

, 2004
Background - Transient (low-conductance) opening of the mitochondrial permeability transition pore (mPTP) may limit mitochondrial calcium load and mediate mitochondrial reactive oxygen species (ROS) signaling.
Wynne, A, Duchen, M, Yellon, D, Hausenloy, D   +3 more
core  

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Liver ischemia preconditions the heart against ischemia-reperfusion arrhythmias [PDF]

Iranian Journal of Basic Medical Sciences, 2015
Objective(s):This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms.
Mohammad-Foad Noorbakhsh, Hossein-Ali Arab, Hamid-Reza Kazerani   +2 more
doaj  

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

Concepts of hypoxic NO signaling in remote ischemic preconditioning

World Journal of Cardiology, 2015
Acute coronary syndromes remain a leading single cause of death worldwide. Therapeutic strategies to treat cardiomyocyte threatening ischemia/reperfusion injury are urgently needed. Remote ischemic preconditioning (rIPC) applied by brief ischemic episodes to heart-distant organs has been tested in several clinical studies, and the major body of ...
Totzeck, Matthias, Hendgen-Cotta, Ulrike B., Rassaf, Tienush   +2 more
openaire   +3 more sources

Data on the effects of remote ischemic preconditioning in the lungs after one-lung ventilation

Data in Brief, 2018
This article contains data on experimental endpoints of a randomized controlled animal trial. Fourteen healthy piglets underwent mechanical ventilation including injurious one-lung ventilation (OLV), seven of them experienced four cycles of remote ...
Astrid Bergmann, Christian Breitling, Göran Hedenstierna, Anders Larsson, Moritz Kretzschmar, Alf Kozian, Thomas Hachenberg, Thomas Schilling   +7 more
doaj   +1 more source

Therapeutic Potential of Gene‐Modified MSC‐Exos in Insulin Resistance: Mitochondrial Crosstalk and miRNA Regulation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Insulin resistance (IR) is the key driver of type 2 diabetes mellitus, metabolic dysfunction‐associated steatotic liver disease, and cardiometabolic disorders. Mesenchymal stem cell‐derived exosomes (MSC‐Exos) as a potent cell‐free alternative can deliver miRNAs, proteins, and mitochondrial regulators to reactivate the IRS1/PI3K/Akt/GLUT4 axis.
Qinghua Jia, Bing Li, Yuan Xing, Yuanyuan Zhang, Baodong Gao, Xiangying Li, Xiaoqin Ha   +6 more
wiley   +1 more source

The effect of remote ischemic preconditioning on ipsilateral testicular morphology postI/R.

, 2023
A. Typical H&E-stained ipsilateral testicular sections after TI/R injury. sham: sham-operated; TI/R: testicular ischemia/reperfusion; RIPC (liver): remote liver ischemic preconditioning; RIPC (limb): remote limb ischemic preconditioning.
Ting Liu (45625), Qifeng Wang (123379), Shichao Wei (3452486), Quanhua Liu (9673184), Jiaxue Li (11924888), Zhaoyang Hu (312662), Zhibing Yan (17290891)   +6 more
core   +1 more source

Bilateral remote ischemic conditioning in children: A two-center, double-blind, randomized controlled trial in young children undergoing cardiac surgeryCentral MessagePerspective

JTCVS Open
Objective: The study objective was to determine whether adequately delivered bilateral remote ischemic preconditioning is cardioprotective in young children undergoing surgery for 2 common congenital heart defects with or without cyanosis.
Nigel E. Drury, PhD, FRCS(CTh), Carin van Doorn, MD, FRCS(CTh), Rebecca L. Woolley, MSc, Rebecca J. Amos-Hirst, MSc, Rehana Bi, BSc(Hons), Collette M. Spencer, BSc(Hons), Kevin P. Morris, MD, FRCPCH, James Montgomerie, MD, FRCA, John Stickley, BSc, Adrian Crucean, MD, Alicia Gill, MSc, Matt Hill, MSc, Ralf J.M. Weber, PhD, Lukas Najdekr, PhD, Andris Jankevics, PhD, Andrew D. Southam, PhD, Gavin R. Lloyd, PhD, Osama Jaber, MD, Imre Kassai, PhD, Giuseppe Pelella, MD, Natasha E. Khan, MD, FRCS(CTh), Phil Botha, PhD, FRCS(CTh), David J. Barron, MD, FRCS(CTh), Melanie Madhani, PhD, Warwick B. Dunn, PhD, Natalie J. Ives, MSc, Paulus Kirchhof, MD, Timothy J. Jones, MD, FRCS(CTh), Edmund D. Carver, Alistair J. Cranston, Fraser Harban, Vasco Laginha Rolo, Ritchie Marcus, Anthony Moriarty, Raju Reddy, Susanna N. Ritchie-McLean, Monica A. Stokes, Ayngara Thillaivasan, Nandlal Bhatia, Carol Bodlani, Wendy Lim, Joe Mellor, Jutta Scheffczik   +42 more
doaj   +1 more source