Results 1 to 10 of about 259,118 (384)
Juxtaglomerular apparatus hyperplasia under dual angiotensin blockade. A footprint of adequate RAS inhibition or a concern for renal fibrosis? [PDF]
BMC Nephrology, 2012 Background Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the renal safety of this approach.
Fernandez-Fernandez Beatriz +5 more
doaj +6 more sources
APOL1 Modulates Renin–Angiotensin System [PDF]
BiomoleculesPatients carrying APOL1 risk alleles (G1 and G2) have a higher risk of developing Focal Segmental Glomerulosclerosis (FSGS); we hypothesized that escalated levels of miR193a contribute to kidney injury by activating renin–angiotensin system (RAS) in the ...
Vinod Kumar +11 more
doaj +2 more sources
The renin–angiotensin system: a possible new target for depression
BMC Medicine, 2017 Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin–angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment ...
João Vian +9 more
doaj +2 more sources
Physiopathology of the Brain Renin-Angiotensin System [PDF]
LifeThe renin-angiotensin system (RAS) has evolved from being considered solely a peripheral endocrine system for cardiovascular control to being recognized as a complex molecular network with important functions in the central nervous system (CNS) and ...
Cristina Cueto-Ureña +3 more
doaj +2 more sources
Novel Antihypertensive Medications to Target the Renin-Angiotensin System: Mechanisms and Research [PDF]
Reviews in Cardiovascular MedicineAn estimated 1.28 billion individuals in the global population suffer from hypertension. Importantly, uncontrolled hypertension is strongly linked to various cardiovascular and cerebrovascular diseases.
Zhe Jiang, Changlin Zhai, Guanmin Tang
doaj +2 more sources
Renin-Angiotensin System: A Review of Historical Perspectives
Galician Medical Journal, 2023 The article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the ...
Olga Kovalyova +2 more
doaj +1 more source
Renin Angiotensin System and Covid-19 Infection [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose The new coronavirus, called SARS-CoV-2, is responsible for the recent global pandemic COVID-19. The status of the global pandemic COVID-19 is currently underway, and the virus has caused about 1.11 million deaths.
Francesco Ferrara, Antonio Vitiello
doaj +1 more source
Renin-Angiotensin System [PDF]
Archives of Andrology, 1988 Renin, a protease that cleaves the prohormone angiotensinogen thereby releasing angiotensin I, plays a major role in regulating blood pressure and electrolyte balance. Although renin is synthesized mainly in the cortical cells of the kidney, the presence of renin or reninlike activity has been recognized in various extrarenal tissues of humans and ...
A, Okuyama +4 more
openaire +2 more sources
A New Perspective on the Renin-Angiotensin System
Diagnostics, 2022 Cardiovascular disease (CVD) is the leading cause of death in the world. Hypertension is a serious medical problem not only in adults but also in children and adolescents.
A. Martyniak, P. Tomasik
semanticscholar +1 more source
Renin-Angiotensin System in Pathogenesis of Atherosclerosis and Treatment of CVD
International Journal of Molecular Sciences, 2021 Atherosclerosis has complex pathogenesis, which involves at least three serious aspects: inflammation, lipid metabolism alterations, and endothelial injury.
A. Poznyak +5 more
semanticscholar +1 more source