Renin-Angiotensin System: A Review of Historical Perspectives [PDF]
Galician Medical Journal, 2023 The article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the ...
Olga Kovalyova +2 more
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Juxtaglomerular apparatus hyperplasia under dual angiotensin blockade. A footprint of adequate RAS inhibition or a concern for renal fibrosis? [PDF]
BMC Nephrology, 2012 Background Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the renal safety of this approach.
Fernandez-Fernandez Beatriz +5 more
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The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis: Evidence from Basic Research and Clinical Studies [PDF]
Mediators of Inflammation, 2009 Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes. The regulation of arterial blood pressure was considered from its first description of the main mechanism involved.
Fabrizio Montecucco +2 more
doaj +5 more sources
Direct pro-inflammatory effects of prorenin on microglia. [PDF]
PLoS ONE, 2014 Neuroinflammation has been implicated in hypertension, and microglia have been proposed to play an important role in the progression of this disease. Here, we have studied whether microglia are activated within cardiovascular regulatory area(s) of the ...
Peng Shi +8 more
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APOL1 Modulates Renin–Angiotensin System [PDF]
BiomoleculesPatients carrying APOL1 risk alleles (G1 and G2) have a higher risk of developing Focal Segmental Glomerulosclerosis (FSGS); we hypothesized that escalated levels of miR193a contribute to kidney injury by activating renin–angiotensin system (RAS) in the ...
Vinod Kumar +11 more
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Nicotine and the renin-angiotensin system [PDF]
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2018 Cigarette smoking is the single most important risk factor for the development of cardiovascular and pulmonary diseases (CVPD). Although cigarette smoking has been in constant decline since the 1950s, the introduction of e-cigarettes or electronic nicotine delivery systems 10 yr ago has attracted former smokers as well as a new generation of consumers.
Eric Lazartigues +4 more
openaire +3 more sources
Management of renin-angiotensin system inhibitors prior to major surgery: insights from the STOP-or-NOT trial. [PDF]
Br J AnaesthStrong recommendations on how to manage renin-angiotensin system inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, before surgery are lacking because of a lack of evidence, which is mostly limited to data ...
Legrand M, Gayat E.
europepmc +3 more sources
The renin-angiotensin system and hypertension
Kidney International, 1979 Presentation of the Forum is made possible by grants from Hoechst-Roussel Pharmaceuticals Inc., Smith Kline & French Laboratories, Burroughs Wellcome Company, Ciba Pharmaceutical Company, and Boehringer Ingelheim Ltd.
Edgar Haber
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Renoprotection, renin inhibition, and blood pressure control: the impact of aliskiren on integrated blood pressure control [PDF]
Integrated Blood Pressure Control, 2010 Haroon-Ur RashidDepartment of Cardiology, Baylor College of Medicine, Texas Heart Institute, Houston, TX, USAAbstract: Hypertension (HTN) is an important factor in progressive loss of renal function.
Haroon-Ur Rashid
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The renin–angiotensin system: a possible new target for depression
BMC Medicine, 2017 Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin–angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment ...
João Vian +9 more
doaj +2 more sources