Results 21 to 30 of about 259,118 (384)

Hepcidin is potential regulator for renin activity

PLoS ONE, 2022
An association between genetic variants in the genes HFE, HJV, BMP4 and arterial hypertension has been shown earlier. Proteins encoded by these genes participate in the signalling routes leading eventually to the production of the peptide hormone ...
Jaakko Piesanen, Jarkko Valjakka, Sanna Niemelä, Marjut Borgenström, Seppo Nikkari, Vesa Hytönen, Juha Määttä, Tarja Kunnas   +7 more
doaj   +2 more sources

New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Characteristics and Usefulness of the Direct Renin Inhibitor Aliskiren

Journal of Pharmacological Sciences, 2010
Since renin inhibition interferes with the first and rate-limiting steps in the renin–angiotensin system, the renin step is a very attractive target for lowering blood pressure and minimizing target-organ damage.
Atsuhiro Ichihara, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Kanako Bokuda, Hiroshi Itoh   +6 more
doaj   +1 more source

Clinical Determinants and Prognostic Implications of Renin and Aldosterone in Patients with Symptomatic Heart Failure [PDF]

, 2020
Aims Activation of the renin-angiotensin-aldosterone system plays an important role in the pathophysiology of heart failure (HF) and has been associated with poor prognosis.
Anker, Stefan D., Dickstein, Kenneth, Duarte, Kevin, Ferreira, Joao Pedro, Girerd, Nicolas, Kobayashi, Masatake, Lamiral, Zohra, Lang, Chim C., Metra, Macro, Ng, Leong L., Preud'homme, Gregoire, Rossignol, Patrick, Samani, Nilesh J., Stienen, Susan, ter Maaten, Jozine M., van Veldhuisen, Dirk J., Voors, Adriaan A., Zannad, Faiez   +17 more
core   +5 more sources

Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations

Clinical Infectious Diseases, 2020
Mortality from coronavirus disease 2019 (COVID-19) is strongly associated with cardiovascular disease, diabetes, and hypertension. These disorders share underlying pathophysiology related to the renin-angiotensin system (RAS) that may be clinically ...
T. Hanff, M. O. Harhay, T. Brown, Jordana B. Cohen, Amir M. Mohareb   +4 more
semanticscholar   +1 more source

COVID-19, Renin-Angiotensin System and Endothelial Dysfunction

Cells, 2020
The newly emergent novel coronavirus disease 2019 (COVID-19) outbreak, which is caused by SARS-CoV-2 virus, has posed a serious threat to global public health and caused worldwide social and economic breakdown.
Razie Amraei, N. Rahimi
semanticscholar   +1 more source

The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)

Physiological Reviews, 2017
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular system and hydroelectrolyte balance, with an influence on organs and functions throughout the body.
R. Santos, W. Sampaio, A. Alzamora, D. Motta-Santos, N. Alenina, M. Bader, M. Campagnole-Santos   +6 more
semanticscholar   +1 more source

Renin-Angiotensin System Blockers and the COVID-19 Pandemic

HYPERTENSION, 2020
During the spread of the severe acute respiratory syndrome coronavirus-2, some reports of data still emerging and in need of full analysis indicate that certain groups of patients are at risk of COVID-19.
A. Danser, M. Epstein, D. Batlle
semanticscholar   +1 more source

Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet [PDF]

, 2017
AIM:To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS:Sprague-Dawley rats were fed with 8% NaCl high-salt (HS) or 0.4% NaCl ...
Cao, Gabriel Fernando, Choi, Marcelo Roberto, Della Penna, Silvana Lorena, Fernandez, Belisario Enrique, Gorzalczany, Susana Beatriz, Kouyoumdzian, Nicolás Martín, Roson, Maria Ines, Toblli, Jorge Eduardo   +7 more
core   +1 more source

Intrarenal renin–angiotensin system [PDF]

Molecular and Cellular Endocrinology, 2009
Phylogenetically the renin-angiotensin system (RAS) is an ancient regulatory system which has attracted the attention of researchers for about a century. As a result of their efforts, different types of RAS inhibitors are now widely used as therapeutic medicines. The scientific enthusiasm toward RAS remains undiminished and new findings and discoveries
openaire   +3 more sources

Increased circulating ANG II and TNF-α represents important risk factors in obese Saudi adults with hypertension irrespective of diabetic status and BMI [PDF]

, 2012
Central adiposity is a significant determinant of obesity-related hypertension risk, which may arise due to the pathogenic inflammatory nature of the abdominal fat depot.
A Berrington de Gonzalez, A Harte, A Taube, AG Bertoni, Aimin Xu, Alison L. Harte, Amany O. Mohamed, AV Chobanian, B Chamarthi, BL Goodwin, BM Celoria, BM Cheung, C Asferg, C Asferg, C Savoia, D Gurantz, D Kalra, D Ma, ES Androulakis, F Galletti, F Galletti, G Mancia, H Itani, H Zhang, Hossam M. Draz, J Feber, J Liu, JD Fowler, JE Hall, JM do Carmo, JV Patel, K Ohashi, KF Adams, Khalid M. Alkharfy, L Alhyas, LE Bautista, Lotfi S. Bindahman, M Adamczak, M Carlyle, M Hernandez-Presa, M Pruijm, M Tohidi, M Vlasova, MA Al-Homrany, Majed S. Alokail, MY Baden, N Al-Daghri, Nasser M. Al-Daghri, NM Al-Daghri, NS Kalupahana, Omar S. Al-Attas, Philip G. McTernan, R Fogari, R Summer, RT Sabo, S Sriramula, S Yasue, Sobhy Yakout, T Wago, TA Kotchen, Tahia H. Saleem, X Gao, Y Deng, Y Takeshita   +63 more
core   +5 more sources