Results 21 to 30 of about 174,628 (339)

ACE2 in the renin–angiotensin system

Clinical Science, 2020
AbstractIn 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2 (ACE2) discovery. This event was a landmark that shaped the way that we see the renin–angiotensin system (RAS) today. ACE2 is an important molecular hub that connects the RAS classical arm, formed mainly by the octapeptide angiotensin II (Ang II) and its ...
Verano-Braga, Thiago, Martins, Ana Luiza Valle, Motta-Santos, Daisy, Campagnole-Santos, Maria José, Santos, Robson Augusto Souza   +4 more
openaire   +3 more sources

Pharmacological effects of raas blockade in ischemic nephropathy [PDF]

, 2016
Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step.
Barbano, Biagio, Cianci, Rosario, Coppolino, Giuseppe, Di Mario, Francesca, Farrah, Tariq E., Fuiano, Giorgio, Gigante, Antonietta, Rivoli, Laura, Rosato, Edoardo   +8 more
core   +1 more source

Influence of Captopril Treatment of Plasma Renin Activity � Mathematical Model

Notulae Scientia Biologicae, 2010
A model of the dynamics of plasma renin activity under the influence of various doses of captopril is formulated. The influence of captopril on renin angiotensin system is different from the effects of the other studied drugs nifedipine and nicardipine.
Kaloyan Bonchev YANKOV, Anna Naidenova TOLEKOVA   +1 more
doaj   +3 more sources

Pathological Role of Angiotensin II in Severe COVID-19

TH Open, 2020
The activated renin–angiotensin system induces a prothrombotic state resulting from the imbalance between coagulation and fibrinolysis. Angiotensin II is the central effector molecule of the activated renin–angiotensin system and is degraded by the ...
Wolfgang Miesbach
doaj   +1 more source

Non-employment and low educational level as risk factors for inequitable treatment and mortality in heart failure: a population-based cohort study of register data

BMC Public Health, 2021
Background The risk of heart failure is disproportionately high among the socioeconomically disadvantaged. Furthermore, socioeconomically deprived patients are at risk of inequitable access to heart failure treatment and poor outcomes.
Anna Ohlsson, Nils Eckerdal, Bertil Lindahl, Marianne Hanning, Ragnar Westerling   +4 more
doaj   +1 more source

Direct pro-inflammatory effects of prorenin on microglia.

PLoS ONE, 2014
Neuroinflammation has been implicated in hypertension, and microglia have been proposed to play an important role in the progression of this disease. Here, we have studied whether microglia are activated within cardiovascular regulatory area(s) of the ...
Peng Shi, Justin L Grobe, Fiona A Desland, Guannan Zhou, Xiao Z Shen, Zhiying Shan, Meng Liu, Mohan K Raizada, Colin Sumners   +8 more
doaj   +1 more source

Role of protein kinase C in inhibition of renin release caused by vasoconstrictors [PDF]

, 1986
It was the aim of the present study to get insight into some of the intracellular mechanisms by which the vasoconstrictor hormones angiotensin II (ANG II), arginine vasopressin (AVP), and norepinephrine (NE) inhibit renin release from renal ...
Bauer, C., Bührle, C., Hackenthal, E., Hutter, A., Kurtz, Armin, Nobiling, R., Pfeilschifter, J., Taugner, R.   +7 more
core   +1 more source

Local renin-angiotensin systems [PDF]

Molecular and Cellular Biochemistry, 1996
The existence of a local cardiovascular renin-angiotensin system (RAS) is often invoked to explain the long-term beneficial effects of RAS inhibitors in heart failure and hypertension. The implicit assumption is that all components of the RAS are synthesized in situ, so that local angiotensin II formation may occur independently of the circulating RAS.
openaire   +2 more sources

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice [PDF]

, 2003
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension.
Aubert, Busetto, Butz, Christopher J. Kenyon, Contreras, Cowley, De la Sieera, Folli, Frederich, Hiroaki Masuzaki, Hiroshi Shinyama, Hiroshi Yamamoto, Janice M. Paterson, Jeffrey S. Flier, Joel K. Elmquist, John J. Mullins, Johnson, Jonathan R. Seckl, Kopelman, Lalouel, Llorens-Cortes, Massiera, Masuzaki, Matthew G.F. Sharp, Miller, Mills, Montani, Morton, Nicholas M. Morton, O’Brien, Pradevand, Pratt, Rotimi, Stepp, Stewart Fleming, Villiquette, Walker, Weinburger, Williams, Yamamoto   +39 more
core   +5 more sources

Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of  ACE2/AT2R/Mas [PDF]

, 2016
High doses of Ang II receptor (AT1R) blockers (ARBs) are renoprotective in diabetes. Underlying mechanisms remain unclear. We evaluated whether high/ultra-high doses of candesartan (ARB) up-regulate angiotensin-converting enzyme 2 (ACE2)/Ang II type 2 ...
Antunes, Tayze, Briones, Ana M., Burns, Kevin, Callera, Glaucia, Correa, Jose, Gutsol, Alexey, He, Ying, Montezano, Augusto C., Moorman, Danielle, Nguyen Dinh Cat, Aurelie, Touyz, Rhian M.   +10 more
core   +1 more source