Results 51 to 60 of about 928,186 (425)

Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials [PDF]

, 2013
The concept of dual blockade of the renin-angiotensin system originated from an experimental model purporting to show a “synergistic” effect between angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers.The concept seemed so ...
Bangalore, Sripal, Desouza, Kavit A, Makani, Harikrishna, Messerli, Franz H, Shah, Arpit   +4 more
core   +2 more sources

Megalin: a Novel Determinant of Renin-Angiotensin System Activity in the Kidney? [PDF]

, 2020
Purpose of Review: Megalin is well known for its role in the reabsorption of proteins from the ultrafiltrate. Recent studies suggest that megalin also reabsorbs renin and angiotensinogen.
Danser, A.H.J. (A. H. Jan), Lu, X. (Xifeng), Sun, Y. (Yuan)   +2 more
core   +1 more source

Clinical implications of left atrial changes after optimization of medical therapy in patients with heart failure

European Journal of Heart Failure, Volume 24, Issue 11, Page 2131-2139, November 2022., 2022
Among patients with new‐onset or worsening heart failure (HF) undergoing optimization of HF medical therapy, dose up‐titration of angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker (ACEi/ARB) therapy was associated with lower likelihood of left atrial adverse remodelling (LAAR).
Riccardo M. Inciardi, Matteo Pagnesi, Carlo M. Lombardi, Stefan D. Anker, John G. Cleland, Kenneth Dickstein, Gerasimos S. Filippatos, Chim C. Lang, Leong L. Ng, Pierpaolo Pellicori, Piotr Ponikowski, Nilesh J. Samani, Faiez Zannad, Dirk J. van Veldhuisen, Scott D. Solomon, Adriaan A. Voors, Marco Metra   +16 more
wiley   +1 more source

New roles for renin and prorenin in heart failure and cardiorenal crosstalk [PDF]

, 2011
The renin-angiotensin-aldosterone-system (RAAS) plays a central role in the pathophysiology of heart failure and cardiorenal interaction. Drugs interfering in the RAAS form the pillars in treatment of heart failure and cardiorenal syndrome. Although RAAS
A Ichihara, A Kurtz, A Kurtz, A Kurtz, A Seed, A Zhou, AA Franken, AA Voors, AH Danser, AH Danser, AR Sielecki, BL Jensen, BL Jensen, BM Massie, C Grunberger, C Mercure, C Newton-Cheh, C Ronco, CA Burckle, Carlo A. J. M. Gaillard, CD Sigmund, CM Cruciat, CP Buhrle, CW Park, D Hartman, D Zeeuw de, Dirk J. van Veldhuisen, DL Feldman, DN Muller, DZ Cherney, E Hackenthal, E O’Brien, EB Toffelmire, ED Burgess, F Schweda, F Suzuki, G Nguyen, G Nguyen, H Castrop, H Castrop, H Krum, H Krum, H Takahashi, Hans L. Hillege, HH Parving, HL Hillege, I Kuipers, I Kuipers, J Burton, J Kong, J Rahuel, JA Luetscher, JB Muhlestein, JF Mann, JG Cleland, JH Esch van, JJ McMurray, JL Rouleau, JN Cohn, K Damman, K Guruprasad, K Hogg, K Kinouchi, K Swedberg, L Chen, L Pan, LG Bongartz, LM Harrison-Bernard, LM Resnick, M Alund, M Bader, M Freundlich, M Gheorghiade, M Hautmann, M Oosterga, M Packer, MA Pfeffer, MA Schalekamp, Mariusz K. Szymanski, MC Ortiz-Capisano, MH Alderman, N Bodyak, ND Fisher, ND Fisher, NI Parikh, Nicolas F. Schroten, O Skott, R Dietz, R Latini, R Vandonge, RE Pratt, RM Fryer, RM Wal van de, Rudolf A. de Boer, S Feldt, S Yusuf, SD Solomon, SD Solomon, SR Holmer, T Ritthaler, T Tsutamoto, TW Meade, UG Friis, Y Huang, Y Huang, Y Huang, Y Kaneshiro, Y Kimura, YC Li   +108 more
core   +3 more sources

The renin-angiotensin system: going beyond the classical paradigms

American Journal of Physiology. Heart and Circulatory Physiology, 2019
Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the discovery of angiotensin-(1−7) [ANG-(1−7)] generation in vivo. Later, angiotensin-converting enzyme 2 (ACE2) was shown to be the main mediator of this reaction, and ...
R. Santos, G. Oudit, T. Verano-Braga, Giovanni Canta, U. Steckelings, M. Bader   +5 more
semanticscholar   +1 more source

BLITZ‐HF: a nationwide initiative to evaluate and improve adherence to acute and chronic heart failure guidelines

European Journal of Heart Failure, Volume 24, Issue 11, Page 2078-2089, November 2022., 2022
Aims To assess adherence to guideline recommendations among a large network of Italian cardiology sites in the management of acute and chronic heart failure (HF) and to evaluate if an ad‐hoc educational intervention can improve their performance on several pharmacological and non‐pharmacological indicators.
Michele Massimo Gulizia, Francesco Orso, Andrea Mortara, Donata Lucci, Nadia Aspromonte, Leonardo De Luca, Giuseppe Di Tano, Giuseppe Leonardi, Alessandro Navazio, Giovanni Pulignano, Furio Colivicchi, Andrea Di Lenarda, Fabrizio Oliva, on behalf of BLITZ‐HF Investigators, G. Pajes, A.R. Felici, P. Midi, G. Leonardi, G. Montana, V. Randazzo, E. Guerri, E. Lo Jacono, V. Zanasi, C. Leuzzi, V. Rizzello, A. Battagliese, N. Pagnoni, G. Pulignano, M. Uguccioni, M.D. Tinti, G.M. Frigo, M. Anselmi, E. Zorzi, I. Battistoni, G.P. Perna, L. Prosseda, M. Pulcini, C. Pellizzari, C. Paolini, G. Bardelli, R. Panciarola, B. Bordoni, S. Urbinati, C. Pedone, C. Greco, E.R. Cosentino, C. Borghi, C. Cuccia, L. Caprini, C. Mariani, C. Borghi, E. Benvenuto, M.B. Zisa, G.M. Francese, M.M. Gulizia, M. Bartolotti, M. Marconi, D. Severini, K. Mboumi, E. Capati, F. Venturi, E. Savini, D. Gabrielli, A. Herbst, F. Orso, F. Sani, C. Minneci, E. Gardini, D. Nanni, C. Lirato, F. Piemonte, P. Ameri, M. Canepa, F. Mainardi, R. Ghinazzi, F. Poletti, C. Inserra, S. Arcidiacono, V. Crisci, C.C. De Carlini, S. Maggiolini, F. Napoli, A.G. Versace, I. Di Matteo, A. Sacco, A.F. Giglio, M.G. Cipriani, G. Mombelli, A. Alberti, V. Antonazzo, O. Agostoni, G. Riboni, G. Guazzotti, S. Mazzetti, A. Mortara, L. Montagna, M.G. Perrelli, L. Scelsi, S. Ghio, A. Gualco, C. Opasich, L. Filippucci, A. Burini, I. Puggia, E. Loiudice, G. Iabichella, A. Nicosia, A. Frisinghelli, G. De Angelis, P. Del Corso, F. Marzo, S. Carigi, G. Piovaccari, S. Refice, T. Nejat, S.A. Di Fusco, F. Colivicchi, D. Pini, P. Romano, G. Padula, A. Gigantino, L. Spera, A. Pagliaro, L.L. Piccioni, C. Napoletano, C. Calcagnile, P. Sbarra, D. Belloli, P.C. Sganzerla, M. Merlo, V. De Paris, M. Driussi, D. Miani, C.A. Gianonatti, L. Moretti, G. Licciardello, V. Palmieri, P. Costa, S. Zingaro, L. Tedesco, A. Iacovoni, M. Liotino, A. Ravera, A. De Castro, G. Rossetti, M. Corda, D. Armata, G. Vianello, E. Pelissero, G. Ruberti, S. D'Orazio, C. Pedrinazzi, D. Robba, A. Carbone, F. De Cian, A. Fucili, F. Grossi, N.D. Brunetti, C. Minoia, M. Pernigo, S. Costa, L. Esposito, G. Senatore, P. Pelaggi, R. Poddighe, E. Zanelli, L. Salvini, G. Galati, A. Zanocco, M. Cannillo, A. Vincenzi, M.A. Losi, L. Caliendo, V. Orrù, E. Carluccio, L. Garritano, E. Garelli, R. Poletti, M. Taglioli, G. Scopelliti, M. Lo Presti, C. Gardini, S. Iosi, C. Tota, M. Mancone, C. De Matteis, F. Rusconi, M.A. Ammirati, G. Cicia, S. Meloni, F. Menozzi, A. Cafro, M. Ribezzo, I. Parrini, S. Giacomelli, G. Russo, F. Morandi, F. Sturniolo   +197 more
wiley   +1 more source

THE INFLUENCE OF TISSUE ANGIOTENSINS ON ELEMENTS OF THE CARDIOVASCULAR SYSTEM (LECTURE)

Байкальский медицинский журнал
Relevance. The renin-angiotensin system is today one of the oldest and most studied peptide cascades. Understanding the operation of this system is an urgent task for study in medical higher education institutions.
Liudmila O Gutsol, Irina E Egorova
doaj   +1 more source

Persistent and selective upregulation of renin-angiotensin system in circulating T lymphocytes in unstable angina. [PDF]

, 2017
Introduction: Unstable angina is associated with an acute systemic inflammatory reaction and circulating T lymphocytes are activated. We investigated whether in unstable angina with marked immune system activation a selective upregulation of the ...
Bandinelli, Manuela, Boddi, Maria, Chiostri, Marco, Coppo, Mirella, Poggesi, Loredana   +4 more
core   +2 more sources

Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure

Pharmacological Reviews, 2019
Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT1R) blockers, current therapies for hypertension and related cardiovascular diseases are still ...
Eric L. Barker, Lauren B. Arendse, A. H. J. Danser, M. Poglitsch, R. Touyz, Jr John C. Burnett, C. Llorens-Cortes, Mario R. Ehlers, E. Sturrock   +8 more
semanticscholar   +1 more source

Guideline‐directed medical therapy in patients undergoing transcatheter edge‐to‐edge repair for secondary mitral regurgitation

European Journal of Heart Failure, Volume 24, Issue 11, Page 2152-2161, November 2022., 2022
Triple guideline‐directed medical therapy (GDMT) prescription was associated with a lower 2‐year mortality compared to non‐triple GDMT prescription (A). Such association was observed in patients with concomitant comorbidities (B). CI, confidence interval; CKD, chronic kidney disease; CMP, cardiomyopathy; HR, hazard ratio; MRA, mineralocorticoid ...
Satoshi Higuchi, Mathias Orban, Marianna Adamo, Cristina Giannini, Bruno Melica, Nicole Karam, Fabien Praz, Daniel Kalbacher, Benedikt Koell, Lukas Stolz, Daniel Braun, Michael Näbauer, Mirjam Wild, Philipp Doldi, Michael Neuss, Christian Butter, Mohammad Kassar, Tobias Ruf, Aniela Petrescu, Sebastian Ludwig, Roman Pfister, Christos Iliadis, Matthias Unterhuber, Francisco Sampaio, Diogo Ferreira, Holger Thiele, Stephan Baldus, Ralph Stephan von Bardeleben, Steffen Massberg, Stephan Windecker, Philipp Lurz, Anna Sonia Petronio, JoAnn Lindenfeld, William T. Abraham, Marco Metra, Jörg Hausleiter, EuroSMR Investigators   +36 more
wiley   +1 more source