Results 1 to 10 of about 264,833 (258)

Revisiting Allostery in the Lac Repressor Protein [PDF]

Biophysical Journal, 2015
The lac repressor protein (lac) is an allosterically regulated transcription factor which controls expression of the lac operon in bacteria. Binding of a small molecule inducer to a site 40A away from the DNA-binding domain relieves repression through what is thought to be local unfolding of the hinge helix.
Matthew A. Stetz, Marie V. Carter, A. Joshua Wand, Kathleen G. Valentine   +3 more
openaire   +2 more sources

Concentration and Length Dependence of DNA Looping in Transcriptional Regulation [PDF]

, 2008
In many cases, transcriptional regulation involves the binding of transcription factors at sites on the DNA that are not immediately adjacent to the promoter of interest.
Beausang, John F., Blumberg, Seth, Garcia, Hernan G., Han, Lin, Nelson, Philip C., Phillips, Rob, Towles, Kevin B.   +6 more
core   +12 more sources

Evi-1 Transforming and Repressor Activities Are Mediated by CtBP Co-repressor Proteins [PDF]

Journal of Biological Chemistry, 2001
Ectopic production of the EVI1 transcriptional repressor zinc finger protein is seen in 4--6% of human acute myeloid leukemias. Overexpression also transforms Rat1 fibroblasts by an unknown mechanism, which is likely to be related to its role in leukemia and which depends upon its repressor activity.
Chris Bartholomew, Anna Kilbey, Jean-Paul Brouillet, Mark Walker, Merlin Crossley, Ruth M. Fulton, Susan Palmer   +6 more
openaire   +3 more sources

Negative feedback control of jasmonate signaling by an alternative splice variant of JAZ10 [PDF]

, 2013
The plant hormone jasmonate (JA) activates gene expression by promoting ubiquitin-dependent degradation of JAZ transcriptional repressor proteins. A key feature of all JAZ proteins is the highly conserved Jas motif, which mediates both JAZ degradation ...
Campos, Marcelo L., Chung, Hoo Sun, He, Sheng Hang, Howe, Gregg A., Moreno, Javier Edgardo, Patel, Lalita C., Shyu, Christine, Yao, Jian   +7 more
core   +1 more source

Analysis of Rice Proteins with DLN Repressor Motif/S [PDF]

International Journal of Molecular Sciences, 2019
Transcriptional regulation includes both activation and repression of downstream genes. In plants, a well-established class of repressors are proteins with an ERF-associated amphiphilic repression/EAR domain. They contain either DLNxxP or LxLxL as the identifying hexapeptide motif. In rice (Oryza sativa), we have identified a total of 266 DLN repressor
Purnima Singh, Iny Mathew, Ankit Verma, Akhilesh Tyagi, Pinky Agarwal   +4 more
openaire   +3 more sources

Effect of promoter architecture on the cell-to-cell variability in gene expression [PDF]

, 2010
According to recent experimental evidence, the architecture of a promoter, defined as the number, strength and regulatory role of the operators that control the promoter, plays a major role in determining the level of cell-to-cell variability in gene ...
A Bar-Even, A Gansen, A Raj, A Raj, A Sanchez, A Singh, A Warmflash, AC Babic, AD Cameron, Alvaro Sanchez, B Muller-Hill, BS Burz, C Zurla, CD Cox, CD Cox, D Kennell, D Müller, D Nevozhay, D Zenklusen, Daniel Jones, DF Browning, DR Rigney, DT Gillespie, DW Austin, E Segal, EM Ozbudak, F Vanzi, F Vanzi, FMV Rossi, G Li, G Tkacik, H Boeger, H Maamar, HD Kim, HD Kim, Hernan G. Garcia, I Golding, IB Dodd, J Elf, J Gertz, J Müller, J Ou, J Paulsson, J Paulsson, J Peccoud, J Yu, Jané Kondev, JK Joung, JK Joung, JM Pedraza, JM Pedraza, JM Raser, JM Vilar, JM Vilar, JR Chubb, JS van Zon, K Gaston, KF Murphy, KS Koblan, L Bintu, L Bintu, L Cai, L Saiz, LS Weinberger, M Ackerman, M Dobrzynski, M Kaern, M Ptashne, M Shin, M Thattai, M Voliotis, MA Shea, MB Elowitz, MF Wernet, MJ Dunlop, N Maheshri, N Rosenfeld, NE Buchler, O Berg, OK Wong, PJ Choi, PJ Ingram, PJ Schlax, PS Gutierrez, PS Swain, R Losik, Rob Phillips, S Klumpp, S Semsey, SB Straney, SE Halford, T Höfer, T Kuhlman, T Raveh-Sadka, TB Kepler, TL To, TP Malan, TS Karpova, U Moran, V Shahrezaei, WJ Blake, WJ Blake, Wyeth W. Wasserman, Y Taniguchi, Y Wang   +104 more
core   +5 more sources

The c1 repressor of bacteriophage P1. Isolation and characterization of the repressor protein.

Journal of Biological Chemistry, 1988
The c1 repressor gene of bacteriophage P1 is located on P1 DNA EcoRI fragment 7 (Sternberg, N. (1979) Virology 96, 129-142). Subfragments of P1 DNA EcoRI fragment 7 were cloned into expression vectors, and the c1 repressor protein from P1 wild-type phage and a revertant of a temperature-sensitive repressor mutant were overproduced in Escherichia coli ...
Brigitte Dreiseikelmann, Heinz Schuster, M Velleman   +2 more
openaire   +3 more sources

DNA Sampling: a method for probing protein binding at specific loci on bacterial chromosomes [PDF]

, 2009
We describe a protocol, DNA sampling, for the rapid isolation of specific segments of DNA, together with bound proteins, from Escherichia coli K-12. The DNA to be sampled is generated as a discrete fragment within cells by the yeast I-SceI meganuclease ...
Blattner, Busby, Butala, Butala, Dame, David J. Lee, Dejardin, Gadgil, Grainger, Grainger, Griffin, Herring, Karp, Kuhar, Lee, Lodge, Matej Butala, Miller, Minchin, Mulec, Murphy, Nordhoff, Pope, Salgado, Spott, Stead, Stephen J. W. Busby, Wang, Westblade, Woo   +29 more
core   +5 more sources

The transcriptional repressor protein PRH interacts with the proteasome [PDF]

Biochemical Journal, 2003
PRH (proline-rich homeodomain protein)/Hex is important in the control of cell proliferation and differentiation. We have shown previously that PRH contains two domains that can bring about transcriptional repression independently; the PRH homeodomain represses transcription by binding to TATA box sequences, whereas the proline-rich N-terminal domain ...
Bess, KL, Swingler, TE, Rivett, AJ, Gaston, K, Jayaraman, P-S   +4 more
openaire   +4 more sources

Strong negative self regulation of Prokaryotic transcription factors increases the intrinsic noise of protein expression [PDF]

, 2008
Background Many prokaryotic transcription factors repress their own transcription. It is often asserted that such regulation enables a cell to homeostatically maintain protein abundance.
A Bar-Even, A Becskei, A de la Hoz, A Kierzek, C Cox, D Austin, Dafyd J Jenkins, Dov J Stekel, E Ozdubak, F Neidhardt, G Shinar, H El-Samad, I Keseler, J Paulsson, J Plumbridge, K Kostelidou, L Bingle, L Cai, M Elowitz, M Gibson, M Keeling, M Koern, M Samoilov, M Simpson, M Simpson, M Thattai, M Wall, N Rosenfeld, P Chivers, P Swain, Q Wang, R Rolfes, S Hooshangi, S Reichheld, T Kepler, Y Dublanche   +35 more
core   +4 more sources