Results 1 to 10 of about 6,797,089 (231)
Chromatin sampling--an emerging perspective on targeting polycomb repressor proteins. [PDF]
PLoS Genetics, 2013 Polycomb group (PcG) repressor proteins play a central role in gene regulation through differentiation and development, conferring repressive chromatin configurations at target gene promoters through their inherent histone modification activities ...
Robert J Klose +4 more
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Evi-1 Transforming and Repressor Activities Are Mediated by CtBP Co-repressor Proteins [PDF]
Journal of Biological Chemistry, 2001 Ectopic production of the EVI1 transcriptional repressor zinc finger protein is seen in 4--6% of human acute myeloid leukemias. Overexpression also transforms Rat1 fibroblasts by an unknown mechanism, which is likely to be related to its role in leukemia and which depends upon its repressor activity.
Palmer, Susan +6 more
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Transcription Past Loop Forming Repressor Proteins [PDF]
Biophysical Journal, 2017 Topology plays a major role in the transcriptional regulation of genetic information. Among the most ubiquitous topological elements are loops that form when proteins simultaneously bind to two non-contiguous sites along the DNA. This topology increases the local concentration of the protein around each of the sites and effectively stabilizes the bound
Zsuzsanna Vörös +2 more
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Nucleic acids research, 1989 The c1 repressor gene of bacteriophage P1 and the temperature-sensitive mutants P1c1.100 and P1c1.162 was cloned into an expression vector and the repressor proteins were overproduced. A rapid purification procedure was required for the isolation of the thermolabile repressor proteins.
J, Heinrich +4 more
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Bacteriophage 434 Hex Protein Prevents RecA-Mediated Repressor Autocleavage [PDF]
Viruses, 2013 In a λimm434 lysogen, two proteins are expressed from the integrated prophage. Both are encoded by the same mRNA whose transcription initiates at the PRM promoter. One protein is the 434 repressor, needed for the establishment and maintenance of
Paul Shkilnyj +2 more
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Interplay of protein and DNA structure revealed in simulations of the lac operon. [PDF]
PLoS ONE, 2013 The E. coli Lac repressor is the classic textbook example of a protein that attaches to widely spaced sites along a genome and forces the intervening DNA into a loop.
Luke Czapla +3 more
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Nature Communications, 2022 Bacteriophage repressor proteins downregulate viral lytic gene expression. Herein, the authors present the X-ray crystal structure of a monomeric repressor that binds an asymmetric DNA sequence using two independent domains.
Reliza J. McGinnis +11 more
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PLoS ONE, 2023 Protein tandem repeats (TRs) are motifs comprised of near-identical contiguous sequence duplications. They are found in approximately 14% of all proteins and are implicated in diverse biological functions facilitating both structured and disordered ...
James A. Davey, Natalie K. Goto
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Dissecting and circumventing the requirement for RAM in CSL-dependent Notch signaling. [PDF]
PLoS ONE, 2012 The Notch signaling pathway is an intercellular communication network vital to metazoan development. Notch activation leads to the nuclear localization of the intracellular portion (NICD) of the Notch receptor.
Scott E Johnson, Douglas Barrick
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Optimization of Cdx Transcription Factors Characteristics
Журнал інженерних наук, 2023 This study presents a new application of TOPSIS for the optimization of transcription factors characteristics. This application is essential as it can help compare the characteristics of these proteins and determine the optimized output of their ...
Javanbakht T.
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