Bacteriophage 434 Hex Protein Prevents RecA-Mediated Repressor Autocleavage [PDF]
Viruses, 2013 In a λimm434 lysogen, two proteins are expressed from the integrated prophage. Both are encoded by the same mRNA whose transcription initiates at the PRM promoter. One protein is the 434 repressor, needed for the establishment and maintenance of
Paul Shkilnyj +2 more
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Chromatin sampling--an emerging perspective on targeting polycomb repressor proteins. [PDF]
PLoS Genetics, 2013 Robert J Klose +4 more
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Interplay of protein and DNA structure revealed in simulations of the lac operon. [PDF]
PLoS ONE, 2013 The E. coli Lac repressor is the classic textbook example of a protein that attaches to widely spaced sites along a genome and forces the intervening DNA into a loop.
Luke Czapla +3 more
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Nature Communications, 2022 Bacteriophage repressor proteins downregulate viral lytic gene expression. Herein, the authors present the X-ray crystal structure of a monomeric repressor that binds an asymmetric DNA sequence using two independent domains.
Reliza J. McGinnis +11 more
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PLoS ONE, 2023 Protein tandem repeats (TRs) are motifs comprised of near-identical contiguous sequence duplications. They are found in approximately 14% of all proteins and are implicated in diverse biological functions facilitating both structured and disordered ...
James A. Davey, Natalie K. Goto
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Evi-1 Transforming and Repressor Activities Are Mediated by CtBP Co-repressor Proteins [PDF]
Journal of Biological Chemistry, 2001 Ectopic production of the EVI1 transcriptional repressor zinc finger protein is seen in 4--6% of human acute myeloid leukemias. Overexpression also transforms Rat1 fibroblasts by an unknown mechanism, which is likely to be related to its role in leukemia and which depends upon its repressor activity.
Palmer, Susan +6 more
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Bacteriophage crosstalk: coordination of prophage induction by trans-acting antirepressors. [PDF]
PLoS Genetics, 2011 Many species of bacteria harbor multiple prophages in their genomes. Prophages often carry genes that confer a selective advantage to the bacterium, typically during host colonization.
Sébastien Lemire +2 more
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Dissecting and circumventing the requirement for RAM in CSL-dependent Notch signaling. [PDF]
PLoS ONE, 2012 The Notch signaling pathway is an intercellular communication network vital to metazoan development. Notch activation leads to the nuclear localization of the intracellular portion (NICD) of the Notch receptor.
Scott E Johnson, Douglas Barrick
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Optimization of Cdx Transcription Factors Characteristics
Журнал інженерних наук, 2023 This study presents a new application of TOPSIS for the optimization of transcription factors characteristics. This application is essential as it can help compare the characteristics of these proteins and determine the optimized output of their ...
Javanbakht T.
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The N-terminal domain of the repressor of Staphylococcus aureus phage Φ11 possesses an unusual dimerization ability and DNA binding affinity. [PDF]
PLoS ONE, 2014 Bacteriophage Φ11 uses Staphylococcus aureus as its host and, like lambdoid phages, harbors three homologous operators in between its two divergently oriented repressor genes. None of the repressors of Φ11, however, showed binding to all three operators,
Anindya Biswas +2 more
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