Results 11 to 20 of about 188,329 (316)

Evidence-Based Structural Model of the Staphylococcal Repressor Protein: Separation of Functions into Different Domains. [PDF]

PLoS ONE, 2015
Horizontal transfer of mobile genetic elements within Staphylococci is of high biomedical significance as such elements are frequently responsible for virulence and toxic effects.
Kinga Nyíri, Bianka Kőhegyi, András Micsonai, József Kardos, Beata G Vertessy   +4 more
doaj   +1 more source

Rules of Expansion: an Updated Consensus Operator Site for the CopR-CopY Family of Bacterial Copper Exporter System Repressors

mSphere, 2020
Copper is broadly toxic to bacteria. As such, bacteria have evolved specialized copper export systems (cop operons) often consisting of a DNA-binding/copper-responsive regulator (which can be a repressor or activator), a copper chaperone, and a copper ...
Henrik O’Brien, Joseph W. Alvin, Sanjay V. Menghani, Yamil Sanchez-Rosario, Koenraad Van Doorslaer, Michael D. L. Johnson   +5 more
doaj   +1 more source

Repressor of temperate mycobacteriophage L1 harbors a stable C-terminal domain and binds to different asymmetric operator DNAs with variable affinity

Virology Journal, 2007
Background Lysogenic mode of life cycle of a temperate bacteriophage is generally maintained by a protein called 'repressor'. Repressor proteins of temperate lambdoid phages bind to a few symmetric operator DNAs in order to regulate their gene expression.
Mandal Nitai C, Das Malabika, Chanda Palas K, Chattoraj Partho, Bandhu Amitava, Ganguly Tridib, Sau Subrata   +6 more
doaj   +1 more source

BiFCROS: A Low-Background Fluorescence Repressor Operator System for Labeling of Genomic Loci

G3: Genes, Genomes, Genetics, 2017
Fluorescence-based methods are widely used to analyze elementary cell processes such as DNA replication or chromosomal folding and segregation. Labeling DNA with a fluorescent protein allows the visualization of its temporal and spatial organization. One
Sarah Milbredt, Torsten Waldminghaus
doaj   +1 more source

Clearance of an amyloid-like translational repressor is governed by 14-3-3 proteins

Cell Reports, 2022
Summary: Amyloids are fibrous protein aggregates associated with age-related diseases. While these aggregates are typically described as irreversible and pathogenic, some cells use reversible amyloid-like structures that serve important functions.
S. Grace Herod, Annie Dyatel, Stefanie Hodapp, Marko Jovanovic, Luke E. Berchowitz   +4 more
doaj   +1 more source

KPNB1 mediates PER/CRY nuclear translocation and circadian clock function

eLife, 2015
Regulated nuclear translocation of the PER/CRY repressor complex is critical for negative feedback regulation of the circadian clock of mammals. However, the precise molecular mechanism is not fully understood.
Yool Lee, A Reum Jang, Lauren J Francey, Amita Sehgal, John B Hogenesch   +4 more
doaj   +1 more source

Transcription Past Loop Forming Repressor Proteins [PDF]

Biophysical Journal, 2017
Topology plays a major role in the transcriptional regulation of genetic information. Among the most ubiquitous topological elements are loops that form when proteins simultaneously bind to two non-contiguous sites along the DNA. This topology increases the local concentration of the protein around each of the sites and effectively stabilizes the bound
Zsuzsanna Vörös, David Dunlap, Laura Finzi   +2 more
openaire   +1 more source

Mobility of the native Bacillus subtilis conjugative plasmid pLS20 is regulated by intercellular signaling.

PLoS Genetics, 2013
Horizontal gene transfer mediated by plasmid conjugation plays a significant role in the evolution of bacterial species, as well as in the dissemination of antibiotic resistance and pathogenicity determinants.
Praveen K Singh, Gayetri Ramachandran, Ricardo Ramos-Ruiz, Ramón Peiró-Pastor, David Abia, Ling J Wu, Wilfried J J Meijer   +6 more
doaj   +1 more source

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

Cell Reports, 2021
Summary: Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ∼30% of HOXAhigh acute myeloid leukemia (AML) cases to confer blocked monocyte/macrophage ...
Fabrizio Simeoni, Isabel Romero-Camarero, Francesco Camera, Fabio M.R. Amaral, Oliver J. Sinclair, Evangelia K. Papachristou, Gary J. Spencer, Michael Lie-A-Ling, Georges Lacaud, Daniel H. Wiseman, Jason S. Carroll, Tim C.P. Somervaille   +11 more
doaj   +1 more source

Two-Hybrid System for Characterization of Protein-Protein Interactions in E. coli

BioTechniques, 2000
The yeast two-hybrid system has been used to characterize many protein-protein interactions. A two-hybrid system for E. coli was constructed in which one hybrid protein bound to a specific DNA site recruits another to an adjacent DNA binding site.
Lori B. Hays, Yuen-Shing A. Chen, James C. Hu   +2 more
doaj   +1 more source