Results 11 to 20 of about 264,833 (258)

Proteins of the ETS family with transcriptional repressor activity [PDF]

Oncogene, 2000
ETS proteins form one of the largest families of signal-dependent transcriptional regulators, mediating cellular proliferation, differentiation and tumorigenesis. Most of the known ETS proteins have been shown to activate transcription. However, four ETS proteins (YAN, ERF, NET and TEL) can act as transcriptional repressors.
Jacques Ghysdael, George Mavrothalassitis   +1 more
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Cholesterol, a repressor of natriuretic proteins

The FASEB Journal, 2019
Salt‐sensitivity in Dahl rats is due, in part, to the reduction of hemoxygenase‐1 (HO1), cyclooxygenase 2 (COX2), and nitric oxide synthase‐2 (NOS2) in the renal medulla. Renal overexpression of HIF1‐α, a regulator of HO1, COX2, and NOS2, enhances salt and water excretion and reduces blood pressure. Cholesterol (chol) incorporation into collecting duct
Robert Repetti, Daniel Flores, Rajeev Rohatgi, Jennifer Meth, Lisa M. Satlin   +4 more
openaire   +1 more source

The STAR protein QKI-6 is a translational repressor [PDF]

Proceedings of the National Academy of Sciences, 1999
The signal transduction and activation of RNA (STAR) family of RNA-binding proteins, whose members are evolutionarily conserved from yeast to humans, are important for a number of developmental decisions. For example, in the mouse, quaking proteins (QKI-5, QKI-6, and QKI-7) are essential for embryogenesis and ...
Eric Jan, Elizabeth B. Goodwin, Karen Artzt, Carrie L. Loushin, Eric Punkay, Lisa Saccomanno   +5 more
openaire   +3 more sources

A single aromatic residue in transcriptional repressor protein KorA is critical for cooperativity with its co-regulator KorB [PDF]

, 2008
A central feature of broad host range IncP-1 plasmids is the set of regulatory circuits that tightly control plasmid core functions under steady-state conditions.
Adamczyk, Bailey, Barnard, Bell, Bhattacharyya, Bignell, Bingle, Bingle, Bingle, Chahla, Chen, Chintakayala, Chiu, Delaglio, Dodd, Feng, Gornall, Grant, Greated, Greated, Jagura-Burdzy, Jagura-Burdzy, Jagura-Burdzy, Jagura-Burdzy, Jain, Jobichen, Kahn, Khare, Kostelidou, Kostelidou, Larsen, Lee, Ling, Lukaszewicz, Macartney, McKenney, Merika, Newberry, Niu, Pace, Pansegrau, Pedersen, Rajasekar, Rhodes, Sambrook, Schneiker, Sevostyanova, Shin, Smith, Studier, Thomas, Tuch, Valentine, Vranken, Wade, Watson, Whitty, Williams, Zatyka, Zukowski   +59 more
core   +2 more sources

Modular Organization of the Phd Repressor/Antitoxin Protein [PDF]

Journal of Bacteriology, 2004
ABSTRACT The P1 plasmid addiction operon is a compact genetic structure consisting of promoter, operator, antitoxin gene ( phd ), and toxin gene ( doc ). The 73-amino-acid antitoxin protein, Phd, has two distinct functions: it represses transcription (by binding to its operator) and
Roy David Magnuson, Jeremy Allen Smith
openaire   +3 more sources

Thecl repressor of bacteriophage P1 operator-repressor interaction of wild-type and mutant repressor proteins

Nucleic Acids Research, 1989
The c1 repressor gene of bacteriophage P1 and the temperature-sensitive mutants P1c1.100 and P1c1.162 was cloned into an expression vector and the repressor proteins were overproduced. A rapid purification procedure was required for the isolation of the thermolabile repressor proteins.
Hans Dieter Riedel, Heinz Suhuster, Barbara R. Baumstark, Makoto Kimura, Jochen Hemrich   +4 more
openaire   +3 more sources

I. Biosynthesis of a Repressor/Nuclease Hybrid Protein

Journal of Biological Chemistry, 1989
The phage T7 endonuclease gene was fused to the 3' end of the lac repressor gene. The hybrid protein exhibits repressor and nuclease functions in a manner dependent on the conformation of the DNA. With supercoiled DNA, nuclease activity is directed to the major cruciform, whereas with linear DNA, the enzyme cleaves preferentially restriction fragments ...
A Fontaine, S Bãckman, N Panayotatos
openaire   +3 more sources

Compositionality, stochasticity and cooperativity in dynamic models of gene regulation

, 2007
We present an approach for constructing dynamic models for the simulation of gene regulatory networks from simple computational elements. Each element is called a ``gene gate'' and defines an input/output-relationship corresponding to the binding and ...
Alberts B, Andrew Phillips, Blossey R, Bundschuh R, Cherry JL, De Jong H, Fall CP, Freidlin MI, Kim J, Lee Deville RE, Luca Cardelli, Milner R, Müller S, Phillips A, Priami C, Ralf Blossey, Smolen P, Thomas R, Thomas R, Van Kampen NG   +19 more
core   +2 more sources

Promoter keyholes enable specific and persistent multi-gene expression programs in primary T cells without genome modification [PDF]

, 2020
Non-invasive epigenome editing is a promising strategy for engineering gene expression programs, yet potency, specificity, and persistence remain challenging.
Acosta, Reyes, Baker, David, Bates, Daniel, Bloom, Jordan, Boyken, Scott E., Chen, Zibo, Ciarlo, Christie, Dunn, Douglass, Federation, Alexander, Funnell, Alister, Green, Shon, Heberlein, Gregory, Liao, Hanna, Nandakumar, Vivek, Otterman, Ericka, Pearl, Jocelynn, Queitsch, Konstantin, Sandstrom, Richard, Schanzer, Elaine, Stamatoyannopoulos, John A., Urnov, Fyodor D., Van Biber, Benjamin, Vong, Shinny, Wang, Hao, Wilken, Matthew S., Zrazhevskey, Pavel   +25 more
core  

Repressor fusions as a tool to study protein–protein interactions [PDF]

Structure, 1995
Genetic reporter systems are necessarily limited in the kinds of information they can provide. The most obvious limitation is that the insides of cells are complex. The phenotype of a gene fusion protein will be determined not only by the property we wish to assay, but also by other effects of the intracellular environment on the chimeric gene product,
openaire   +3 more sources