Results 231 to 240 of about 264,833 (258)

Lactose Repressor Protein: Functional Properties and Structure

1997
The lactose repressor protein (LacI), the prototype for genetic regulatory proteins, controls expression of lactose metabolic genes by binding to its cognate operator sequences in E. coli DNA. Inducer binding elicits a conformational change that diminishes affinity for operator sequences with no effect on nonspecific binding. The release of operator is
Kathleen S. Matthews, Jeffry C. Nichols
openaire   +3 more sources

Ligand interactions with lactose repressor protein and the repressor-operator complex: The effects of ionization and oligomerization on binding

Biophysical Chemistry, 2007
Specific interactions between proteins and ligands that modify their functions are crucial in biology. Here, we examine sugars that bind the lactose repressor protein (LacI) and modify repressor affinity for operator DNA using isothermal titration calorimetry and equilibrium DNA binding experiments.
Corey J. Wilson, Liskin Swint-Kruse, Kathleen S. Matthews, Hongli Zhan   +3 more
openaire   +3 more sources

Thermodynamic Analysis of Unfolding and Dissociation in Lactose Repressor Protein

Biochemistry, 1999
Lactose repressor protein, regulator of lac enzyme expression in Escherichia coli, maintains its structure and function at extremely low protein concentrations (
Kathleen S. Matthews, Jennifer K. Barry
openaire   +3 more sources

The Trp Repressor, A Ligand-Activated Regulatory Protein

1992
Publisher Summary This chapter discusses the role of Trp repressor as a ligand-activated regulatory protein. The Trp repressor (protein) of Escherichia coli is one of the most exhaustively studied DNA-binding regulatory macromolecules. Its physiological role is to reduce or eliminate transcription from certain regulatable promoters through the ...
openaire   +3 more sources

Characterization and modification of a monomeric mutant of the lactose repressor protein

Biochemistry, 1986
A monomeric mutant lactose repressor protein (T-41), containing serine at position 282 in place of tyrosine [Schmitz, A., Schmeissner, U., Miller, J. H., & Lu, P. (1976) J. Biol. Chem. 251, 3359-3366], has been purified by a series of chromatographic and precipitation methods.
Kathleen S. Matthews, Thomas J. Daly
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Capsid protein of f2 as translational repressor

Biochemical and Biophysical Research Communications, 1967
Kathleen Shive, Raymond C. Valentine, Richard Ward   +2 more
openaire   +3 more sources

Molecular Characterization of the VIP Receptor Transcriptional Repressor Protein

Annals of the New York Academy of Sciences, 2000
Abstract: The rat type 1 VIP receptor transcriptional repressor protein (VIPR‐RP) is a recently isolated novel transcription factor. In the study reported here, the functional domains of VIPR‐RP were characterized. To map the DNA binding domain, various regions of VIPR‐RP were either transcribed and translated in vitro or expressed in and purified ...
openaire   +3 more sources

Nanooncology: The future of cancer diagnosis and therapy

Ca-A Cancer Journal for Clinicians, 2013
Avnesh S Thakor
exaly  

MicroRNAome genome: A treasure for cancer diagnosis and therapy

Ca-A Cancer Journal for Clinicians, 2014
Ioana Berindan-neagoe, Barbara Pasculli, George A Calin   +2 more
exaly  

Application of Nanotechnology in Cancer Therapy and Imaging

Ca-A Cancer Journal for Clinicians, 2008
Dong M Shin
exaly