Results 21 to 30 of about 264,833 (258)

A Repressor Protein Complex Regulates Leaf Growth in Arabidopsis [PDF]

The Plant Cell, 2015
Cell number is an important determinant of final organ size. In the leaf, a large proportion of cells are derived from the stomatal lineage. Meristemoids, which are stem cell-like precursor cells, undergo asymmetric divisions, generating several pavement cells adjacent to the two guard cells.
Dominique Eeckhout, Dominique Eeckhout, Astrid Nagels Durand, Astrid Nagels Durand, Rebecca De Clercq, Rebecca De Clercq, Alexandra Baekelandt, Alexandra Baekelandt, Nienke Besbrugge, Nienke Besbrugge, Dirk Inzé, Dirk Inzé, Alain Goossens, Alain Goossens, Jelle Van Leene, Jelle Van Leene, Geert De Jaeger, Geert De Jaeger, Klaas Vandepoele, Klaas Vandepoele, Ken S. Heyndrickx, Ken S. Heyndrickx, Liesbeth De Milde, Liesbeth De Milde, Laurens Pauwels, Laurens Pauwels, Robin Vanden Bossche, Robin Vanden Bossche, Eveline Van De Slijke, Eveline Van De Slijke, Nathalie Gonzalez, Nathalie Gonzalez, Amparo Cuéllar Pérez, Amparo Cuéllar Pérez, Kris Gevaert   +34 more
openaire   +5 more sources

A dominant repressor version of the tomatoSl-ERF.B3gene confers ethylene hypersensitivity via feedback regulation of ethylene signaling and response components [PDF]

, 2013
Ethylene Response Factors (ERFs) are downstream components of the ethylene signal transduction pathway, although their role in ethylene-dependent developmental processes remains poorly understood. As the ethylene-inducible tomato Sl-ERF.B3 has been shown
Achard, Allen, Alonso, Benavente, Berrocal-Lobo, Bleecker, Brown, Chakravarthy, Chao, Dubois, Fujimoto, Gu, Gu, Hall, Hao, Heyl, Hiratsu, Hua, Johnson, Ju, Kevany, Kevany, Kieber, Leclercq, Lee, Li, Lin, Magome, Matsui, Matsui, McGrath, Mitsuda, Nakano, Ohme-Takagi, Oñate-Sánchez, Pan, Pirrello, Pirrello, Pré, Riechmann, Sasaki, Solano, Solano, Tieman, Tieman, Tournier, Trujillo, van der Fits, Wang, Wuriyanghan, Yokotani, Zhang   +51 more
core   +2 more sources

The trans-activation domain of the sporulation response regulator Spo0A revealed by X-ray crystallography [PDF]

, 2000
Sporulation in Bacillus involves the induction of scores of genes in a temporally and spatially co-ordinated programme of cell development. Its initiation is under the control of an expanded two-component signal transduction system termed a phosphorelay.
Baldus J.M., Brown D.P., Buckner C.M., Buckner C.M., Busby S., Chung J.D., Cowtan K., Ferrari F.A., Fogh R.H., Green B.D., Grimsley J.K., Hatt J.K., Igarashi K., Ireton K., Kenney T.J., Kondo H., Kuldell N., Makino K., Martinez-Hackert E., Muchova K., Murshudov G.N., Olmedo G., Perego M., Satola S.W., Schyns G., Spiegelman G.B., Spiegelman G.B., Strauch M.A., Strauch M.A., Terwilliger T.C., Weir J., Wu H.-M., York K.   +32 more
core   +1 more source

The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors [PDF]

Biochemical Journal, 2008
The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a transcription factor that functions as an important regulator of vertebrate development and many other processes in the adult including haematopoiesis.
Hannah Williams, Tracey E. Swingler, Peter J. Noy, Kevin Gaston, Cecile Desjobert, Padma-Sheela Jayaraman, Padma-Sheela Jayaraman   +6 more
openaire   +5 more sources

DNA looping: the consequences and its control [PDF]

, 2006
The formation of DNA loops by proteins and protein complexes is ubiquitous to many fundamental cellular processes, including transcription, recombination, and replication.
Ackers, Adhya, Alberts, Becker, Bloomfield, Broach, Cloutier, de Lange, Dodd, Du, Dunn, Halford, Hanke, Hill, Irani, Jose MG Vilar, Knight, Leonor Saiz, Lewis, Li, Matthews, Moreau, Mossing, Muller, Müller-Hill, Oehler, Olson, Ptashne, Ptashne, Radman-Livaja, Revet, Richmond, Ringrose, Rippe, Saiz, Saiz, Schleif, Semsey, Stenger, Tolhuis, Vilar, Vilar, Villa, Yan, Yasmin, Zhang   +45 more
core   +1 more source

Diffusion of transcription factors can drastically enhance the noise in gene expression [PDF]

, 2006
We study by simulation the effect of the diffusive motion of repressor molecules on the noise in mRNA and protein levels in the case of a repressed gene.
Ander, Andrews, Andrews, Austin, Berg, Berg, Bialek, Bray, Bremer, Cai, Coppey, Delbruck, Detwiler, Eigen, Elf, Elowitz, Elowitz, Gerland, Gillespie, Gillespie, Golding, Golding, Gowers, Halford, Hornos, Hu, Jeroen S. van Zon, Kaern, Karmakar, Kepler, Kim, Klenin, Ko, Kushner, Lewis, Marco J. Morelli, McAdams, McClure, Metzler, Novick, Ozbudak, Paulsson, Paulsson, Peccoud, Pedraza, Pieter Rein ten Wolde, Pirone, Rao, Record, Revyakin, Riggs, Rigney, Rosenfeld, Shibata, Shoup, Simpson, Slutsky, Smoluchowski, Sorin Tǎnase-Nicola, Stanford, Swain, Tanase-Nicola, Thattai, Valitutti, van Kampen, van Kampen, van Zon, van Zon, Vilar, Warren, Warren, Yu   +71 more
core   +4 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

A quantitative comparison of sRNA-based and protein-based gene regulation [PDF]

, 2008
Small, non-coding RNAs (sRNAs) play important roles as genetic regulators in prokaryotes. sRNAs act post-transcriptionally via complementary pairing with target mRNAs to regulate protein expression.
Berg HC, Ned S Wingreen, Pankaj Mehta, Ptashne M, Sidhartha Goyal, van Kampen NG   +5 more
core   +3 more sources

Chemical synthesis of a fully active transcriptional repressor protein. [PDF]

Proceedings of the National Academy of Sciences, 1994
Plasmid pLS1-encoded 45-amino acid transcriptional repressor CopG (formerly RepA) has been chemically synthesized. A one-step purification of the synthetic protein has been developed, which yields high levels of pure protein with low or no contamination of truncated products.
Solar, Gloria del, Albericio, Fernando, Eritja Casadellà, Ramón, Espinosa, Manuel   +3 more
openaire   +4 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source