Results 41 to 50 of about 264,833 (258)

Stat3 in Resident Macrophages as a Repressor Protein of Inflammatory Response [PDF]

The Journal of Immunology, 2005
Abstract Inflammation is counterbalanced by anti-inflammatory cytokines such as IL-10, in which Stat3 mediates the signaling pathway. In this study, we demonstrate that resident macrophages, but not other cell types, are important targets of IL-10 in a murine model of acute peritonitis. Injection of thioglycollate i.p.
Kousuke Numata, Kiyoshi Takeda, Shinji Kudo, Takaaki Ito, Akihiro Matsukawa, Shizuo Akira, Takako Maeda, Hiroyuki Watanabe   +7 more
openaire   +3 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

From DNA sequence to application: possibilities and complications [PDF]

, 1999
The development of sophisticated genetic tools during the past 15 years have facilitated a tremendous increase of fundamental and application-oriented knowledge of lactic acid bacteria (LAB) and their bacteriophages.
A Bruttin, A Bruttin, A Kraus, A Nauta, A Nauta, A Nauta, A Sazicu, AK Aggarwal, B Christiansen, B Christiansen, BC Lokman, BC Lokman, BM Chassy, C Delorme, C Hill, C Schouler, CA Alpert, CA Shearman, CJ Hueck, CO Pabo, CT Verrips, D Botstein, D Lillehaug, D Lillehaug, D Sinderen, DJ O’Sullivan, DJ O’Sullivan, DO Gostick, DO Gostick, E Küster, E Maguin, E Stanley, EJ Luesink, EJ Luesink, EJ Luesink, F Desiere, F Desiere, G Buist, G Buist, G Ramsay, G Vriend, GM Djordjevic, GM Djordjevic, H Brüssow, H Holo, H Neve, I Biswas, J Bardowski, J Bernhardt, J Green, J Law, J Payne, J Stülke, JB Luchansky, JD Boyce, JW Sanders, JW Sanders, JW Sanders, K Chung, K Leenhouts, K Leenhouts, K Leenhouts, K Schnetz, KI Kodaira, KJ Leenhouts, L Dupont, L Dupont, LJ Beamer, LR Garcia, M Curie, M de Guchte, M de Guchte, M Lieb, M Ptashne, MG Johnsen, MJ Gasson, MJ Weickert, MM Sheehan, MW Lubbers, MW Lubbers, N Goupil-Feuillerat, OP Kuipers, P Hals, PG Ruyter, PGGA Ruyter, PL Madsen, PS Chandry, R Parreira, R Schmid, R Young, R Young, RR Raya, S Challou, S Lucchini, S Lucchini, S Simonen, S Spiro, S Spiro, SA Walker, SB Mclvilc, SG Kim, SM Heller, SM Madsen, SR Swindell, T Sasaki, TM Ramseier, V Vagner, WM Vos, WM Vos, WM Vos, Y Fujita   +110 more
core   +3 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Modeling of negative autoregulated genetic networks in single cells

, 2005
We discuss recent developments in the modeling of negative autoregulated genetic networks. In particular, we consider the temporal evolution of the population of mRNA and proteins in simple networks using rate equations. In the limit of low copy numbers,
Becskei, Biham, Biham, Elowitz, Elowitz, Elowitz, Gibson, Gibson, Gillespie, Gould, Green, Hartquist, Hollenbach, Hollenbach, Kalir, Kepler, Ko, Ko, Lipshtat, McAdams, McAdams, Milo, Milo, Morton-Firth, Murray, Nicolis, Paulsson, Paulsson, Paulsson, Paulsson, Rosenfeld, Smith, Swain, Szallasi, Yagil, Yagil   +35 more
core   +2 more sources

Stochastic models and numerical algorithms for a class of regulatory gene networks [PDF]

, 2008
Regulatory gene networks contain generic modules like those involving feedback loops, which are essential for the regulation of many biological functions.
Fournier, Thomas, Gabriel, Jean-Pierre, Galbete, Jose, Mazza, Christian, Mermod, Nicolas, Pasquier, Jerome   +5 more
core   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Construction and utilisation of a bidirectional reporter vector in the analysis of two nod-boxes in of Rhizobium loti : a thesis presented in partial fulfilment of the requirements for the Degree of Master of Science in Molecular Genetics at Massey University [PDF]

, 1993
The nod-box is a 47bp cis-acting regulatory region which has been conserved amongst every species of Rhizobium studied to date. In species such as R. meliloti and R.
Parry, Simon Keith
core  

Self consistent proteomic field theory of stochastic gene switches

, 2004
We present a self-consistent field approximation to the problem of the genetic switch composed of two mutually repressing/activating genes. The protein and DNA state dynamics are treated stochastically and on equal footing.
Ackers, Arkin, Aurell, Becskei, Bialek, Buchler, Cook, Darling, Doi, Gillespie, Hasty, Hasty, Hasty, Kepler, McAdams, McLure, Paulsson, Ptashne, Ptashne, Sasai, Sneppen, Swain, Thattai, Vilar, Zeldovich   +24 more
core   +2 more sources

Regulation of Synaptic Pumilio Function by an Aggregation-Prone Domain [PDF]

, 2010
We identified Pumilio (Pum), a Drosophila translational repressor, in a computational search for metazoan proteins whose activities might be regulated by assembly into ordered aggregates.
Menon, Kaushiki P., Salazar, Anna M., Silverman, Edward J., Zinn, Kai   +3 more
core   +2 more sources