Results 51 to 60 of about 6,797,208 (350)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Construction and utilisation of a bidirectional reporter vector in the analysis of two nod-boxes in of Rhizobium loti : a thesis presented in partial fulfilment of the requirements for the Degree of Master of Science in Molecular Genetics at Massey University [PDF]

, 1993
The nod-box is a 47bp cis-acting regulatory region which has been conserved amongst every species of Rhizobium studied to date. In species such as R. meliloti and R.
Parry, Simon Keith
core  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Exploiting a Phage-Bacterium Interaction System as a Molecular Switch to Decipher Macromolecular Interactions in the Living Cell

Viruses, 2018
Pathogenicity islands of Staphylococcus aureus are under the strong control of helper phages, where regulation is communicated at the gene expression level via a family of specific repressor proteins.
Éva Viola Surányi, Rita Hírmondó, Kinga Nyíri, Szilvia Tarjányi, Bianka Kőhegyi, Judit Tóth, Beáta G. Vértessy   +6 more
doaj   +1 more source

Modeling of negative autoregulated genetic networks in single cells

, 2005
We discuss recent developments in the modeling of negative autoregulated genetic networks. In particular, we consider the temporal evolution of the population of mRNA and proteins in simple networks using rate equations. In the limit of low copy numbers,
Becskei, Biham, Biham, Elowitz, Elowitz, Elowitz, Gibson, Gibson, Gillespie, Gould, Green, Hartquist, Hollenbach, Hollenbach, Kalir, Kepler, Ko, Ko, Lipshtat, McAdams, McAdams, Milo, Milo, Morton-Firth, Murray, Nicolis, Paulsson, Paulsson, Paulsson, Paulsson, Rosenfeld, Smith, Swain, Szallasi, Yagil, Yagil   +35 more
core   +2 more sources

DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers [PDF]

, 2010
Protein self-organization is essential for the establishment and maintenance of nuclear architecture and for the regulation of gene expression. We have shown previously that the Proline-Rich Homeodomain protein (PRH/Hex) self-assembles to form oligomeric
A. Sawasdichai, A. Shukla, A. Soufi, Bess, Butcher, C. Smith, Cai, Cairns, Crompton, D'Elia, Dafforn, de Los Rios, Desjobert, Galande, Gaston, Gaston, Gaston, Goldman, Jennings, K. Gaston, Katsani, Larquet, Lennard, Luger, Luijsterburg, Martino, Mohd-Sarip, P. Noy, P.-S. Jayaraman, Puppin, Sekiya, Song, Soufi, Soufi, Soufi, T. Dafforn, Tanny, Thaw, Topisirovic, Vernon, Williams, Yasui   +41 more
core   +5 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Dynamic model of gene regulation for the lac operon [PDF]

, 2011
Gene regulatory network is a collection of DNA which interact with each other and with other matter in the cell. The lac operon is an example of a relatively simple genetic network and is one of the best-studied structures in the Escherichia coli ...
Asma Ben-Halim, Bower J, Kloeden P E, Maia Angelova, Murray J D, Ptashne M, Stark H, van Hoek M   +7 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source