Results 81 to 90 of about 6,797,208 (350)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator

eLife, 2018
MarR (multiple antibiotic resistance repressor) family proteins are bacterial repressors that regulate transcription in response to a wide range of chemical signals.
Daiana A Capdevila, Fidel Huerta, Katherine A Edmonds, My Tra Le, Hongwei Wu, David P Giedroc   +5 more
doaj   +1 more source

Lateral Gene Expression in Drosophila Early Embryos Is Supported by Grainyhead-Mediated Activation and Tiers of Dorsally-Localized Repression [PDF]

, 2011
The general consensus in the field is that limiting amounts of the transcription factor Dorsal establish dorsal boundaries of genes expressed along the dorsal-ventral (DV) axis of early Drosophila embryos, while repressors establish ventral boundaries ...
A Jazwinska, A Ozdemir, A Stathopoulos, A Stathopoulos, Angelike Stathopoulos, B Adryan, B Biehs, B Schnepp, BD Dynlacht, BJ Rutledge, C Ghiglione, C Lanzuolo, C Mizutani, C Nusslein-Volhard, C Rushlow, Christos Samakovlis, D Kosman, D Stein, DH Huang, E Bier, E Ferguson, E Zandi, F Jimenez, G Jimenez, G Pyrowolakis, GJ Liaw, GT Reeves, H Chu, H Dai, H Lee, H-L Liang, HJ Doyle, J Cowden, J Huang, J Jiang, J Jiang, J Jiang, J Kadonaga, JB Weiss, JW Hodgson, K Arora, K Staehling-Hampton, L Ajuria, LM Liberman, LM Liberman, M Grillo, M Kim, Mayra Garcia, MM Harrison, N Perrimon, NC Grieder, R Cornell, RP Ray, S Luschnig, S Small, S Urban, S Wang, SJ Bray, T Isshiki, T Von Ohlen, U Weber, V Morel, YT Ip, YT Ip   +63 more
core   +5 more sources

The Krüppel-associated Box (KRAB)-Zinc Finger Protein Kid-1 and the Wilms’ Tumor Protein WT1, Two Transcriptional Repressor Proteins, Bind to Heteroduplex DNA*

Journal of Biological Chemistry, 1997
Zinc finger proteins of the Cys2His2 class represent a large group of DNA-binding proteins. A major subfamily of those proteins, the Krüppel-associated box (KRAB) domain-containing Cys2His2-zinc finger proteins, have been described as potent ...
B. Elser, W. Kriz, J. Bonventre, C. Englert, R. Witzgall   +4 more
semanticscholar   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Stochastic Gene Expression in Single Gene Oscillator Variants [PDF]

, 2016
It is infeasible to understand all dynamics in cell, but we can aim to understand the impact of design choices under our control. Here we consider a single gene oscillator as a case study to understand the influence of DNA copy number and repressor ...
Bennett, Matthew R., Gomez, Marcella M., Murray, Richard M., Shis, David L., Swaminathan, Anandh   +4 more
core  

An enhanced CRISPR repressor for targeted mammalian gene regulation. [PDF]

, 2018
The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its utility.
Cecchi, Ryan J, Chan, Yingleong, Chavez, Alejandro, Church, George M, Church, George M, Collins, James J, Davidsohn, Noah, Ebrahimkhani, Mo R, Guo, Xiaoge, Kiani, Samira, Kuo, Chih-Chung, Lance-Byrne, Alissa, Lewis, Nathan E, Lim, Elaine T, Menn, David, Milanova, Denitsa, Pradhan, Swechchha, Sharma, Sumana, Tung, Angela, Tuttle, Marcelle, Yeo, Nan Cher   +20 more
core   +1 more source

The Transcription Repressor REST in Adult Neurons: Physiology, Pathology, and Diseases,,

eNeuro, 2015
REST [RE1-silencing transcription factor (also called neuron-restrictive silencer factor)] is known to repress thousands of possible target genes, many of which are neuron specific.
P. Baldelli, J. Meldolesi
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Repressor fusions as a tool to study protein–protein interactions [PDF]

Structure, 1995
Genetic reporter systems are necessarily limited in the kinds of information they can provide. The most obvious limitation is that the insides of cells are complex. The phenotype of a gene fusion protein will be determined not only by the property we wish to assay, but also by other effects of the intracellular environment on the chimeric gene product,
openaire   +2 more sources