Results 21 to 30 of about 90,613,697 (136)
Syndrome of Resistance to Thyroid Hormone: Insights into Thyroid Hormone Action
Experimental Biology and Medicine, 1996 Thyroid hormones (T3, T4) exert multiple cellular effects through nuclear thyroid hormone receptors (TR alpha, TR beta). Thyroid hormone receptors are transcription factors that act by altering patterns of gene expression. Resistance to thyroid hormone (RTH) is a rare disorder caused by mutations in the TR beta gene.
P, Kopp, K, Kitajima, J L, Jameson
openaire +2 more sources
Trends in Pediatrics, 2023 In children, abnormal thyroid function tests (TFTs) can present diagnostic difficulty due to the variety of clinical manifestations that may accompany them.
Gözde Akın Kağızmanlı, Korcan Demir
doaj +1 more source
Thyroid hormone resistance syndrome [PDF]
, 2011 Abstract Thyroid hormones (thyroxine T4 and triiodothyronine T3) regulate many cellular processes in virtually every type of tissue. The diverse effects of thyroid hormone include regulation of growth, control of basal metabolic rate, enhanced myocardial contractility, and functional differentiation of the central nervous system.
Mark Gurnell, V. Krishna Chatterjee
openaire +1 more source
Identification of a novel THRB mutation causing thyroid hormone resistance syndrome [PDF]
Archives of Endocrinology and MetabolismResistance to thyroid hormone syndrome (RTHS) is a rare disorder caused by mutations in the thyroid hormone receptor beta (THRB) gene, resulting in impaired action of thyroid hormones on target tissues and organs.
Jing Yang +3 more
doaj +2 more sources
Resistance to Thyroid Hormone Beta: A Focused Review
Frontiers in Endocrinology, 2021 Resistance to thyroid hormone (RTH) is a clinical syndrome defined by impaired sensitivity to thyroid hormone (TH) and its more common form is caused by mutations in the thyroid hormone receptor beta (THRB) gene, termed RTHβ.
Theodora Pappa, Samuel Refetoff
doaj +1 more source
SYNDROME OF RESISTANCE TO THYROID HORMONE
Journal of the ASEAN Federation of Endocrine Societies, 2023 INTRODUCTION/BACKGROUNDResistance to thyroid hormone (RTH) is a rare genetic disorder characterized by clinically mild hyperthyroidism and biochemically elevated circulating free thyroid hormone levels with unsuppressed serum thyroid stimulating hormone.
openaire +1 more source
Thyroid Hormone Receptor Mutations in Cancer and Resistance to Thyroid Hormone: Perspective and Prognosis [PDF]
, 2011 Thyroid hormone, operating through its receptors, plays crucial roles in the control of normal human physiology and development; deviations from the norm can give rise to disease. Clinical endocrinologists often must confront and correct the consequences
Martin L. Privalsky, Meghan D. Rosen
core +1 more source
Journal of International Medical Research, 2022 Thyroid hormone resistance syndrome (THRS) is a rare disease characterized by reduced sensitivity to thyroid hormones. Mutations in the thyroid hormone receptor beta ( THRB ) gene are considered as contributing to the pathogenesis.
Zongyan Xie +4 more
doaj +1 more source
Journal of Medical Case Reports, 2012 Introduction Resistance to thyroid hormone is a syndrome caused by thyroid hormone receptor β mutations, which are usually inherited in an autosomal-dominant pattern.
Yatsuga Shuichi +6 more
doaj +1 more source
中国甲状腺功能正常人群对甲状腺激素的敏感性和代谢综合征组分的风险
Journal of Diabetes, 2023 Introduction To evaluate the association of sensitivity to thyroid hormone with metabolic syndrome (MetS) and its components in a Chinese euthyroid population. Methods A total of 3573 participants from Pinggu Metabolic Disease Study were analyzed.
Fang Lv +6 more
doaj +1 more source