Results 31 to 40 of about 90,613,697 (136)

Resistance to Thyroid Hormone in the Absence of Mutations in the Thyroid Hormone Receptor Genes

, 2004
Resistance to thyroid hormone (RTH) is a syndrome of reduced tissue sensitivity to thyroid hormone. In the majority of subjects, RTH is caused by mutant thyroid hormone receptors (TR) ß molecules that interfere with the function of the normal TRß, thus ...
Refetoff, Samuel, Reutrakul, Sirimon, Sadow, Peter M, Mannavola, Deborah, Pohlenz, Joachim, Weiss, Roy E, Dennis, Kimberly, Kimberly Dennis, Samuel Refetoff, Deborah Mannavola, Roy E. Weiss, Sirimon Reutrakul, Joachim Pohlenz, Peter M. Sadow   +13 more
core   +1 more source

Thyroid hormone resistance syndrome. Inhibition of normal receptor function by mutant thyroid hormone receptors. [PDF]

Journal of Clinical Investigation, 1991
Thyroid hormone (T3) resistance is inherited in most cases in an autosomal dominant manner. The disorder is characterized by elevated free thyroid hormone levels and partial resistance to thyroid hormone at the cellular level. Distinct single amino acid substitutions in the ligand binding domain of the beta form of the thyroid hormone receptor have ...
Chatterjee, V. Krishna K., Nagaya, Takashi, Madison, Laird D., Datta, Shoumen, Rentoumis, Anne, Jameson, Larry J.   +5 more
openaire   +3 more sources

Thyroid Hormone Receptor Beta Gene Mutation (P453A) in a Family Producing Resistance to Thyroid Hormone

, 2008
Background: Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome characterized by decreased responsiveness of target tissues to thyroid hormone. Two members of a Turkish family, a mother and son, had thyroid function tests suggestive of
J. Noel, Bayraktaroglu, T., N. Mukaddes, Alagol, F., N. Colak, Mulkaddes, N. M., Colak, N., T. Bayraktaroglu, F. Alagol, Refetoff, S., S. Refetoff, Noel, J.   +11 more
core   +1 more source

Resistance to Thyroid Hormone (RTH)

, 2004
The syndrome of resistance to thyroid hormone (RTH) is characterized by reduced tissue responsiveness to thyroid hormone (TH) despite elevated circulating levels of free triiodothyronine (T3) and thyroxine (T4).
Roy E. Weiss, Gisah Amaral de Carvalho, de Carvalho, Gisah Amaral, Weiss, Roy E   +3 more
core   +1 more source

Retinal photoreceptor functions are compromised in patients with resistance to thyroid hormone syndrome (RTHβ)

, 2017
In animal models, disruption of thyroid hormone receptor-beta (TRβ) reduces the medium-wavelength (L/M) and increases the short-wavelength (S)-cones. The retinal photoreceptors (RPs) functions are unknown in patients with resistance to thyroid hormone ...
MIAN, CATERINA, I. Campi, F. Viola, Irene Campi, D. Dazzi, Francesco Viola, Santarsiero, Diletta, C. Pelusi, Davide Dazzi, Campi, Irene, Stefania Bianchi Marzoli, D. Santarsiero, S. Watuntantrige Fernando, Beck Peccoz, Paolo, Dazzi, Davide, L. Persani, Maria Antonia Maffini, M. Muzza, Paolo Beck-Peccoz, Carla Pelusi, Watuntantrige-Fernando, Sara, Watuntantrige Fernando, Sara, Muzza, Marina, G. Cammarata, Diletta Santarsiero, WATUTANTRIGE FERNANDO, SARA, Gabriella Cammarata, E.G. Taroni, Luca Persani, Alessandra Bottari de Castello, Bianchi Marzoli, Stefania, P. Beck-Peccoz, S. Bianchi Marzoli, M.A. Maffini, Cammarata, Gabriella, Viola, Francesco, Beck-Peccoz, Paolo, Caterina Mian, Taroni, Elena Giuliana, Bottari de Castello, Alessandra, Persani, Luca, Maffini, Maria Antonia, Pelusi, Carla, C. Mian, Sara Watutantrige-Fernando, A. Bottari de Castello, Elena Giuliana Taroni, Marina Muzza   +47 more
core   +1 more source

Longitudinal evidence of the impact of normal thyroid stimulating hormone variations on cognitive functioning in very old age [PDF]

, 2008
The purpose of this study was to examine longitudinal associations among thyroid stimulating hormone (TSH) levels and cognitive performance. Data collected at the first three assessment times, approximately 3 years apart, are reported for the survivors ...
Wahlin, TBR, Wahlin, A, Bunce, D
core   +3 more sources

Thyroid-stimulating Hormone and Insulin Resistance: Their Association with Polycystic Ovary Syndrome without Overt Hypothyroidism

, 2017
Objective This study analyzed the effectiveness of the thyroid-stimulating hormone (TSH) as a predictor of insulin resistance (IR) and its association with the clinical and metabolic parameters of women with polycystic ovary syndrome (PCOS) without ...
Cristina Laguna Benetti-Pinto (4661203), Vanessa Berini Piccolo (12726428), Heraldo Garmes (12726431), Daniela Angerame Yela (4661212)   +3 more
core   +1 more source

Three new mutations of thyroid hormone receptor-beta associated with resistance to thyroid hormone

, 1994
Three novel point mutations at nucleotides 1249, 1282, and 1614 (exons 9 and 10) of the human thyroid hormone receptor-beta gene were observed in six individuals affected by the syndrome of resistance to thyroid hormone. All three mutations occurred in a
Pontecorvi, Alfredo, REGALBUTO C, TRIMARCHI, Francesco, BENVENGA, Salvatore, PONTECORVI A., FILETTI S, BARTOLONE, LUIGI   +6 more
core   +1 more source

ODP521 THYROID HORMONE RESISTANCE SYNDROME

Journal of the Endocrine Society, 2022
Abstract Introduction The Thyroid hormone resistance syndrome is characterized by decreased tissue sensitivity to thyroid hormones. The incidence is about 1/50,000. We present two clinical cases of this disease. Clinical case 1A 59-year-old woman was evaluated for presenting palpitations for more than
Franco, Katty Manrique, Manrique, Helard
openaire   +1 more source

THYROID HORMONE RESISTANCE SYNDROME (THR)

Journal of the ASEAN Federation of Endocrine Societies, 2023
INTRODUCTION/BACKGROUNDThyroid hormone resistance syndrome (THR) is a rare condition caused by defects in either one of the two thyroid hormone receptors which leads to tissue unresponsiveness to circulating thyroid hormones. The presentations vary depending on which receptor is affected.
W Mohd Hilmi bin W. Omar, Jia Cheng Ong, Suhaimi Hussain   +2 more
openaire   +1 more source