Results 91 to 100 of about 8,166 (214)

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections [PDF]

, 2016
Endogenous mechanisms leading to host protection and resolution of infections without immunosuppression are of wide interest1,2. Here we elucidated the structures of four new host-protective molecules produced in neutrophil-endothelial co-cultures, and ...
Chiang, Nan, Dalli, Jesmond, Serhan, Charles   +2 more
core   +1 more source

Resolvins as potential candidates for the treatment of major depressive disorder

, 2021
In contrast with the delayed onset of therapeutic responses and relatively low efficacy of currently available monoamine-based antidepressants, a single subanesthetic dose of ketamine, an N-methyl-D-aspartate receptor antagonist, produces rapid and ...
Satoshi Deyama, Katsuyuki Kaneda, Masabumi Minami   +2 more
core   +1 more source

Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance

Periodontology 2000, EarlyView.
Abstract Background Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent ...
Michael Wolf, Ulrike Schulze‐Späte, Thomas Van Dyke, Stefan Wolfart, Thomas Dietrich, Alberto Ortiz, Zhuojun Wu, Joachim Jankowski   +7 more
wiley   +1 more source

Impaired Resolution of Inflammation in Alzheimer’s Disease: A Review

Frontiers in Immunology, 2017
Alzheimer’s disease (AD) remains the leading cause of dementia worldwide, and over the last several decades, the role of inflammation in the pathogenesis of this neurodegenerative disorder has been increasingly elucidated.
Robert A. Whittington, Emmanuel Planel, Emmanuel Planel, Niccolò Terrando   +3 more
doaj   +1 more source

Decoding host–microbial dynamics in peri‐implantitis: Ecosystem‐specific experimental models

Periodontology 2000, EarlyView.
Abstract Background Peri‐implantitis is an inflammatory disease arising within a unique host–microbial–biomaterial ecosystem. Unlike periodontitis, peri‐implant tissues lack a periodontal ligament and epithelial junction integrity and interface with metal oxides on titanium surfaces.
Georgios A. Kotsakis, Davi Araújo, Asaf Wilensky, Juliana Girón Bastidas, Stella Alimperti, Flavia Pirih   +5 more
wiley   +1 more source

On the Total Synthesis of 7,8(S,S)-Epoxy-17(S)-hydroxy-4(Z),9(E),11(E),13(Z),15(E),19(Z)-docosahexaenoic Acid Derivative

Molecules
The stereoselective total synthesis of an allylic epoxide-containing polyunsaturated fatty acid, in its triethylsilyl (TES) ether and methyl ester form, is described.
Robert Nshimiyimana, Charles N. Serhan, Nicos A. Petasis   +2 more
doaj   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Trophoblast Extracellular Vesicles Rewire Immunity: A Symptom‐Relief Avenue for Recessive Dystrophic Epidermolysis Bullosa

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
First‐trimester trophoblast EVs are enriched in anti‐inflammatory proteins, lipids, and immunoregulatory miRNAs. EVT‐EVs reprogram monocytes toward a pro‐resolving phenotype and restore immune homeostasis in RDEB, supporting their potential as offering a scalable off‐the‐shelf therapy for chronic inflammatory diseases.
Nell Hirt, Enzo Manchon, Ming Wu, Helene Le Buanec, Pauline Bataille, Emmanuelle Bourrat, Jean‐David Bouaziz, Nabila Jabrane‐Ferrat, Reem Al‐Daccak   +8 more
wiley   +1 more source

Resolvins resolve to heal mucosal wounds [PDF]

Proceedings of the National Academy of Sciences, 2020
Surfaces lined by single or multiple layers of epithelial cells, termed mucosal surfaces, function as selectively permeable barriers that partition the host from the outside world. Given their proximity to microbes and microbial antigens, intestinal epithelial cells (IECs) have evolved mechanisms to maintain barrier function and to aid in promoting ...
openaire   +2 more sources

Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins [PDF]

, 2017
Atherogenesis is an inflammatory process with leukocytes infiltrating the arterial intima. The lipoxygenase pathways play a role in leukocyte recruitment through the generation of two classes of arachidonic acid lipid mediators, the leukotrienes and the ...
Hersberger, Martin
core