Results 81 to 90 of about 10,096 (216)

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Resolvins and protectins: mediating solutions to inflammation [PDF]

British Journal of Pharmacology, 2009
Resolution of inflammation has historically been viewed as a passive process, occurring as a result of the withdrawal of pro‐inflammatory signals, including lipid mediators such as leukotrienes and prostaglandins. Thus, most anti‐inflammatory drugs have traditionally targeted primarily mediator pathways that are engaged at the onset of inflammation ...
Payal, Kohli, Bruce D, Levy
openaire   +2 more sources

A Novel Modified-Curcumin Promotes Resolvin-Like Activity and Reduces Bone Loss in Diabetes-Induced Experimental Periodontitis

Journal of Inflammation Research, 2021
Jie Deng,1 Lorne M Golub,2 Hsi-Ming Lee,2 Veena Raja,2 Francis Johnson,3 Allan Kucine,4 Wonsae Lee,5 Tian-Min Xu,1 Ying Gu6 1Department of Orthodontics, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral ...
Deng J, Golub LM, Lee HM, Raja V, Johnson F, Kucine A, Lee W, Xu TM, Gu Y   +8 more
doaj  

Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications

Frontiers in Pharmacology, 2018
Diabetes and its associated chronic complications present a healthcare challenge on a global scale. Despite improvements in the management of chronic complications of the micro-/macro-vasculature, their growing prevalence and incidence highlights the ...
Monica de Gaetano, Caitriona McEvoy, Caitriona McEvoy, Darrell Andrews, Antonino Cacace, Jonathan Hunter, Eoin Brennan, Catherine Godson   +7 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Ex Vivo Human Skin as a Platform to Study Cosmetic Modulation of Specialized Pro-Resolving Mediators

Cosmetics
Chronic low-grade inflammation and oxidative stress induced by the exposome represent key drivers of skin aging and related imperfections. The development of experimental models suitable for studying these metabolic processes is therefore of primary ...
Michele Massironi, Lorenzo Zanella, Francesca Benato, Camila Paz Quezada Meza, Chiara Rompietti, Sandro Rosa, Dominik Stuhlmann, Martina Herrmann, Marco Massironi   +8 more
doaj   +1 more source

Short-term n-3 fatty acid supplementation but not aspirin increases plasma proresolving mediators of inflammation[S]

Journal of Lipid Research, 2014
Resolution of inflammation is an active process involving specialized proresolving mediators (SPM) formed from the n-3 fatty acids. This study examined the effect of n-3 fatty acid supplementation and aspirin on plasma SPMs in healthy humans.
Anne Barden, Emilie Mas, Kevin D. Croft, Michael Phillips, Trevor A. Mori   +4 more
doaj   +1 more source

Periodontitis and Rheumatoid Arthritis—Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
Periodontitis and rheumatoid arthritis are linked via the two‐hit model whereby early periodontal inflammation can lead to autoantibody production capable of interacting with inflamed synovial tissues. Subsequent systemic inflammation can exacerbate the periodontal inflammatory response and bacterial dysbiosis leading to further autoantibody production
Mark Bartold, Chia Wei Cheah, Rathna Devi Vaithilingam   +2 more
wiley   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Resolvin inflammation with pain [PDF]

Expert Opinion on Investigational Drugs, 2010
Background: Inflammation and pain coexist in conditions such as arthritis, inflammatory bowel disease, and lower back pain. The drugs currently used to treat the combination of inflammation and pain all have disadvantages. Thus, new drugs and new approaches are needed to treat inflammation with pain.
openaire   +2 more sources