Results 11 to 20 of about 54,681 (257)
Bisretinoids of the Retina: Photo-Oxidation, Iron-Catalyzed Oxidation, and Disease Consequences
Antioxidants, 2021 The retina and, in particular, retinal pigment epithelial cells are unusual for being encumbered by exposure to visible light, while being oxygen-rich, and also amassing photoreactive molecules.
Hye Jin Kim +3 more
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Matrix Metalloproteinase 13 Is Associated with Age-Related Choroidal Neovascularization
Antioxidants, 2023 Age-related macular degeneration (AMD) is a leading cause of severe vision loss in older individuals in developed countries. Despite advances in our understanding of AMD, its pathophysiology remains poorly understood.
Jorge González-Zamora +8 more
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Generating retinal neurons by reprogramming retinal pigment epithelial cells [PDF]
Expert Opinion on Biological Therapy, 2010 Retinal degenerations cause blindness. One potential therapy is cell replacement. Because the human retina lacks regeneration capacity, much attention has been directed towards searching for cells that can differentiate into retinal neurons.We discuss the possibility of using transcription factor genes to channel retinal pigment epithelial (RPE) cells'
Shu-Zhen, Wang +3 more
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PLoS ONE, 2022 Chloroquine often causes serious eye and vision problems, which are mainly mediated by lysosomotropic alteration. In this study, we investigated whether the ginsenoside protopanaxadiol relieves chloroquine-induced retinopathy by restoring lysosomotropic ...
Haesung Lee +2 more
doaj +3 more sources
Microorganisms, 2022 Prevalence of dengue retinopathy varies across epidemics, with the disease linked to circulation of dengue virus serotype 1 (DENV-1). The retinal pigment epithelium has been implicated in the pathology.
Liam M. Ashander +8 more
doaj +1 more source
The effects of growth factors on multicellular spheroids formed by chick embryonic retinal cells [PDF]
, 1997 Retinal cells from chick embryos aged 7.5 days of gestation were cultured for two months in a non-adherent suspension culture dish to study the effects of growth factors and co-culture with retinal pigment epithelial cells on their differentiation ...
Matsuo, Nobuhiko +2 more
core +1 more source
Ocular immune privilege and retinal pigment epithelial cells
Journal of Leukocyte Biology, 2023 AbstractThe ocular tissue microenvironment is immune-privileged and uses multiple immunosuppressive mechanisms to prevent the induction of inflammation. The retinal pigment epithelium plays an essential role in ocular immune privilege. In addition to serving as a blood barrier separating the fenestrated choriocapillaris from the retina, the retinal ...
Yuxiang, Du, Bo, Yan
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Communications Biology, 2022 The in vivo pathogenesis of the blinding retinal degeneration choroideremia is visualized, which reveals enlarged and area-disrupted retinal pigment epithelial cells, providing evidence for polymegathism in choroideremia.
Nancy Aguilera +24 more
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Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells. [PDF]
, 2012 The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured
Birke, Kerstin +3 more
core +3 more sources
Exocytosis by Retinal Pigment Epithelial Cells
Ophthalmic Research, 1985 We observed cultured retinal pigment epithelial cells as they responded to the introduction of latex particles. The cells showed phagocytosis of particles 1 h after administration of latex and were filled with particles after 24 h. After 7 days, exocytosis of latex from basal plasma membrane was documented.
M, Matsumura +4 more
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