Results 181 to 190 of about 155,897 (329)

Strong Signatures of Selection on Candidate Genes Underlying Core Speciation Mechanisms in Desert Tortoises

Molecular Ecology Resources, Volume 25, Issue 6, August 2025.
ABSTRACT Genomic incompatibilities and differential ecological adaptation are thought to be fundamental mechanisms of speciation. In this study, we generated a chromosome‐scale reference genome and annotation for Gopherus morafkai , the Sonoran Desert tortoise, and conducted a detailed analysis of genes under positive selection with its sister species,
Sarah M. Baty, Raúl Araya‐Donoso, Avery Paulsen, Avery Williams, Dale F. DeNardo, Kenro Kusumi, Greer A. Dolby   +6 more
wiley   +1 more source

Inverse agonists of retinoic acid receptor/retinoid X receptor signaling as lineage-specific antitumor agents against human adenoid cystic carcinoma. [PDF]

J Natl Cancer Inst, 2023
Viragova S, Aparicio L, Palmerini P, Zhao J, Valencia Salazar LE, Schurer A, Dhuri A, Sahoo D, Moskaluk CA, Rabadan R, Dalerba P.   +10 more
europepmc   +1 more source

Dimerization interfaces of thyroid hormone, retinoic acid, vitamin D, and retinoid X receptors

, 1993
Evan D. Rosen, Eric Beninghof, Ronald J. Koenig   +2 more
openalex   +1 more source

Differential 9-cis-Retinoic Acid-dependent Transcriptional Activation by Murine Retinoid X Receptor α (RXRα) and RXRβ [PDF]

, 1996
Paul L. Hallenbeck, Saverio Minucci, Roland E. Lippoldt, M. Phyillaier, Valerie J. Horn, Keiko Ozato, Vera M. Nikodem   +6 more
openalex   +1 more source

Role for the liver X receptor agonist 22‐ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

British Journal of Pharmacology, Volume 182, Issue 16, Page 3744-3766, August 2025.
Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens, Na Zhan, Sammie C. Yam, Marcella Palumbo, Lorenzo Pontini, Frank P. J. Leijten, Leonie van Vark‐van der Zee, Gardi Voortman, Silvia Friedrichs, Albert Gerding, Maura Marinozzi, Johan W. Jonker, Folkert Kuipers, Dieter Lütjohann, Tim Vanmierlo, Monique T. Mulder   +15 more
wiley   +1 more source

Modulating retinoid-X-receptor alpha (RXRA) expression sensitizes chronic myeloid leukemia cells to imatinib in vitro and reduces disease burden in vivo. [PDF]

Front Pharmacol, 2023
Rajamani BM, Illangeswaran RSS, Benjamin ESB, Balakrishnan B, Jebanesan DZP, Das S, Pai AA, Vidhyadharan RT, Mohan A, Karathedath S, Abraham A, Mathews V, Velayudhan SR, Balasubramanian P.   +13 more
europepmc   +1 more source

Artemisinins in autoimmune diseases: effects and mechanisms in systemic lupus erythematosus and rheumatoid arthritis

British Journal of Pharmacology, Volume 182, Issue 15, Page 3411-3427, August 2025.
Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self‐tolerance loss, causing tissue damage. Standard treatments targeting late‐stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.
Fanchao Zhou, Guoming Li, Ruixiang Tan, Guodong Wu, Changsheng Deng   +4 more
wiley   +1 more source

A Novel in Duck Myoblasts: The Transcription Factor Retinoid X Receptor Alpha (RXRA) Inhibits Lipid Accumulation by Promoting CD36 Expression. [PDF]

Int J Mol Sci, 2023
Pan Z, Chen X, Wu D, Li X, Gao W, Li G, Du G, Zhang C, Jin S, Geng Z.   +9 more
europepmc   +1 more source

Coordinated Regulation of and Transcriptional Activation by Xenopus Thyroid Hormone and Retinoid X Receptors [PDF]

, 1995
Jiemin Wong, Yun‐Bo Shi
openalex   +1 more source

Vitamin D Supplementation Improves Muscle Mass, Physical Function, and Quality of Life in Patients With Degenerative Lumbar Disease

Clinical and Translational Science, Volume 18, Issue 8, August 2025.
ABSTRACT Degenerative lumbar disease is a significant contributor to acute or chronic musculoskeletal issues in the elderly, often associated with low serum 25‐hydroxyvitamin D (25(OH)D) levels. The effect of vitamin D2 supplementation on muscle mass, strength, and physical performance remains unclear.
Sinsuda Dechsupa, Wicharn Yingsakmongkol, Worawat Limthongkul, Weerasak Singhatanadgige, Suvichada Assawakosri, Sittisak Honsawek   +5 more
wiley   +1 more source