Results 61 to 70 of about 155,897 (329)

The Promiscuity of Allosteric Regulation of Nuclear Receptors by Retinoid X Receptor [PDF]

The Journal of Physical Chemistry B, 2016
The promiscuous protein retinoid X receptor (RXR) displays essential allosteric regulation of several members in the nuclear hormone receptor superfamily via heterodimerization and (anti)cooperative binding of cognate ligands. Here, the structural basis of the positive allostery of RXR and constitutive androstane receptor (CAR) is revealed. In contrast,
Richard J. Lindsay, Ricky B. Nellas, Alexander K. Clark, Tongye Shen, Aaron W. Grayson, Elias J. Fernandez, Quentin R. Johnson, J. Heath Wilder   +7 more
openaire   +3 more sources

Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

Nature Communications, 2019
The truncated form of retinoid X receptor-alpha is found in cancer. Here, the authors show that this mutant receptor promotes colorectal tumorigenesis by activation of NF-κB in myeloid cells, leading to subsequent IL-6-induced STAT3 activation in ...
Xiaohong Ye, Hua Wu, Luoyan Sheng, Yi-xin Liu, Fang Ye, Mo Wang, Hu Zhou, Ying Su, Xiao-kun Zhang   +8 more
doaj   +1 more source

In vitro anti-angiogenic properties of LGD1069, a selective retinoid X-receptor agonist through down-regulating Runx2 expression on Human endothelial cells

BMC Cancer, 2011
Background LGD1069 (Targretin®) is a selective retinoid X receptor (RXR) ligand, which is used in patients for cutaneous T-cell lymphoma. Our published study reported that LGD1069 inhibited tumor-induced angiogenesis in non-small cell lung cancer.
Lu Hong, Liu Yu-Hui, Wang Wei, Fu Jianjiang, Luo Yongming   +4 more
doaj   +1 more source

Liposomal delivery of hydrophobic RAMBAs provides good bioavailability and significant enhancement of retinoic acid signalling in neuroblastoma tumour cells [PDF]

, 2020
Retinoid treatment is employed during residual disease treatment in neuroblastoma, where the aim is to induce neural differentiation or death in tumour cells.
Bilip, Maja, Di Florio, Alessia, Eaton, Simon, Hart, Stephen L., Irving, Elsa, Maeshima, Ruhina, Mathiyalakan, Mayuran, Orford, Michael, Shah, Shreya, Simons, Claire, Stoker, Andrew W., Tagalakis, Aristides D.   +11 more
core   +4 more sources

Genetic variants in the retinoid X receptor gene contribute to osteoarthritis susceptibility [PDF]

Archives of Biological Sciences
Osteoarthritis (OA) is a progressive disease of the joints that causes a gradual loss of function, resulting in limited mobility. Chronic inflammation is the main molecular process that triggers and propagates this disease. The retinoid X receptor (RXR),
Štefik Debora, Vranić Vladimir, Ivković Nemanja, Božić-Nedeljković Biljana, Šupić Gordana   +4 more
doaj   +1 more source

Linking Induction and Transrepression of PPARβ/δ with Cellular Function [PDF]

, 2015
The copyrights of all papers published in this journal are retained by the respective authors as per the 'Creative Commons Attribution License' (http://creativecommons.org/licenses/by/3.0/).Peroxisome proliferator activated receptors (PPARs) are ligand ...
MacKenzie, Louise Susan, Perez Diaz, Noelia   +1 more
core   +3 more sources

Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function [PDF]

Proceedings of the National Academy of Sciences, 2007
Retinoid X receptors (RXRα, -β, and -γ) occupy a central position in the nuclear receptor superfamily, because they form heterodimers with many other family members and hence are involved in the control of a variety of (patho)physiologic processes.
Nahoum, Virginie, Pérez, Efrén, Germain, Pierre, Rodríguez-Barrios, Fátima, Manzo, Fabio, Kammerer, Sabrina, Lemaire, Geraldine, Hirsch, Oliver, Royer, Catherine A, Gronemeyer, Hinrich, de Lera, Angel R, Bourguet, William   +11 more
openaire   +5 more sources

Advances in breast cancer treatment and prevention: preclinical studies on aromatase inhibitors and new selective estrogen receptor modulators (SERMs). [PDF]

, 2003
Intensive basic and clinical research over the past 20 years has yielded crucial molecular understanding into how estrogen and the estrogen receptor act to regulate breast cancer and has led to the development of more effective, less toxic, and safer ...
Brown, Powel H, Chamness, Gary C, Schiff, Rachel   +2 more
core   +2 more sources

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Retinoid X receptor alpha forms tetramers in solution. [PDF]

Proceedings of the National Academy of Sciences, 1995
Protein-protein interactions allow the retinoid X receptor (RXR) to bind to cognate DNA as a homo- or a heterodimer and to participate in mediating the effects of a variety of hormones on gene transcription. Here we report a systematic study of the oligomeric state of RXR in the absence of a DNA template.
Pierre Chambon, Desi Kelleher, Noa Noy, Sander Kersten, Hinrich Gronemeyer   +4 more
openaire   +4 more sources