Retinoic Acid and Retinoid X Receptors [PDF]
Cells, 2023 One of the most fundamental discoveries in human biology was that of the existence of essential micronutrients that the body cannot synthesize but nonetheless requires for proper functioning [...]
Michael Schubert, Pierre Germain
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The Crucial Involvement of Retinoid X Receptors in DDE Neurotoxicity. [PDF]
Neurotox Res, 2016 Dichlorodiphenyldichloroethylene (DDE) is a primary environmental and metabolic degradation product of the pesticide dichlorodiphenyltrichloroethane (DDT). It is one of the most toxic compounds belonging to organochlorines.
Wnuk A +6 more
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The retinoid X receptors and their ligands. [PDF]
Biochim Biophys Acta, 2012 This chapter presents an overview of the current status of studies on the structural and molecular biology of the retinoid X receptor subtypes α, β, and γ (RXRs, NR2B1-3), their nuclear and cytoplasmic functions, post-transcriptional processing, and recently reported ligands.
Dawson MI, Xia Z.
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Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease. [PDF]
Br J Pharmacol, 2019 After 15 years of research into Alzheimer's disease (AD) therapeutics, including billions of US dollars provided by federal agencies, pharmaceutical companies, and private foundations, there are still no meaningful therapies that can delay the onset or ...
Fitz NF +3 more
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Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling. [PDF]
J Clin Invest, 2015 Osteoclasts are bone-resorbing cells that are important for maintenance of bone remodeling and mineral homeostasis. Regulation of osteoclast differentiation and activity is important for the pathogenesis and treatment of diseases associated with bone ...
Menéndez-Gutiérrez MP +9 more
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Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia [PDF]
Biology Open, 2022 Transcriptome analyses performed in both human and zebrafish indicate strong expression of Apoe and Apoc1 by microglia. Apoe expression by microglia is well appreciated, but Apoc1 expression has not been well-examined.
Whitney A. Thiel +4 more
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Coordinated Regulation of and Transcriptional Activation by Xenopus Thyroid Hormone and Retinoid X Receptors (*) [PDF]
Journal of Biological Chemistry, 1995 Thyroid hormone (T3) plays a causative role in amphibian metamorphosis. This regulation is thought to be mediated by heterodimers of T3 receptors (TRs) and retinoid X receptors (RXRs).
J. Wong, Yunbo Shi
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Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity. [PDF]
J Neurosci, 2015 Mounier A +9 more
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Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth [PDF]
Current Issues in Molecular BiologyTazarotene, a retinoid derivative, is widely used in treating skin conditions such as psoriasis and acne. Recent studies have demonstrated its potential as a promising therapeutic agent for treating melanoma in situ.
Chun-Hua Wang, Lu-Kai Wang, Fu-Ming Tsai
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Regulation of retinoid-mediated signaling involved in skin homeostasis by RAR and RXR agonists/antagonists in mouse skin. [PDF]
PLoS ONE, 2013 Endogenous retinoids like all-trans retinoic acid (ATRA) play important roles in skin homeostasis and skin-based immune responses. Moreover, retinoid signaling was found to be dysregulated in various skin diseases.
Janine Gericke +7 more
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