The retinoid X receptors and their ligands [PDF]
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2012 This chapter presents an overview of the current status of studies on the structural and molecular biology of the retinoid X receptor subtypes α, β, and γ (RXRs, NR2B1-3), their nuclear and cytoplasmic functions, post-transcriptional processing, and recently reported ligands.
Dawson MI, Xia Z.
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Retinoic Acid and Retinoid X Receptors [PDF]
Cells, 2023 One of the most fundamental discoveries in human biology was that of the existence of essential micronutrients that the body cannot synthesize but nonetheless requires for proper functioning [...]
Michael Schubert, Pierre Germain
doaj +5 more sources
Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity. [PDF]
J Neurosci, 2015 Mounier A +9 more
europepmc +4 more sources
Retinoid X receptors: X-ploring their (patho)physiological functions [PDF]
Cell Death and Differentiation, 2004 Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription factors that regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as heterodimerization partner for their function. This places RXR in the crossroad of multiple distinct biological pathways.
Laszlo Nagy
exaly +4 more sources
Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease. [PDF]
Br J Pharmacol, 2019 After 15 years of research into Alzheimer's disease (AD) therapeutics, including billions of US dollars provided by federal agencies, pharmaceutical companies, and private foundations, there are still no meaningful therapies that can delay the onset or ...
Fitz NF +3 more
europepmc +2 more sources
The Crucial Involvement of Retinoid X Receptors in DDE Neurotoxicity. [PDF]
Neurotox Res, 2016 Dichlorodiphenyldichloroethylene (DDE) is a primary environmental and metabolic degradation product of the pesticide dichlorodiphenyltrichloroethane (DDT). It is one of the most toxic compounds belonging to organochlorines.
Wnuk A +6 more
europepmc +2 more sources
Retinoid X receptors in macrophage biology [PDF]
Trends in Endocrinology & Metabolism, 2013 Retinoid X receptors (RXRs) form a distinct and unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs regulate a plethora of genetic programs, including cell differentiation, the immune response, and lipid and glucose metabolism.
Tamás Rőszer +3 more
semanticscholar +4 more sources
Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia [PDF]
Biology Open, 2022 Transcriptome analyses performed in both human and zebrafish indicate strong expression of Apoe and Apoc1 by microglia. Apoe expression by microglia is well appreciated, but Apoc1 expression has not been well-examined.
Whitney A. Thiel +4 more
doaj +2 more sources
Bexarotene signaling in human B and T lymphocytes induces gut-homing receptor expression [PDF]
Frontiers in ImmunologyBackgroundRetinoic acid (RA) receptors (RARs) in human lymphocytes modulate the humoral and intestinal immune response by regulating target genes, including CD38, TGM2, and gut-homing markers.
Sina Kaiser +6 more
doaj +2 more sources
Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling. [PDF]
J Clin Invest, 2015 Menéndez-Gutiérrez MP +9 more
europepmc +2 more sources