Results 91 to 100 of about 122,450 (299)

Regulation of cellular senescence by retinoid X receptors and their partners

Mechanisms of Ageing and Development, 2019
Cellular senescence is a response characterized by a stable cell proliferation arrest and a senescence-associated secretory phenotype (SASP) which can be induced by many stresses, including telomere shortening and oncogene activation. Senescence is crucially involved in a variety of physiopathological contexts, such as cancer and aging.
Nadine Martin, Xingjie Ma, David Bernard
openaire   +4 more sources

Sevoflurane induces the inattention, cognitive impairment, and motor dysfunction by hypermethylation of retinoic acid receptor α in the medial prefrontal cortex of neonatal mice

VIEW, EarlyView.
The mechanisms underlying neurodevelopmental toxicity induced by repeated exposure to general anesthesia in neonatal mice remain to be fully elucidated. In this study, neonatal mice were exposed to sevoflurane on postnatal days 6, 8, and 10. On postnatal day 30, the medial prefrontal cortex was collected for whole‐genome bisulfite sequencing and RNA ...
Yu Hou, Shuai Li, Qi Hou, Runjia Wang, Zhenghao Deng, Xiyuan Xu, Zhichao Li, Linhui Ma, Yuan Shen, Qidong Liu, Hui Zheng   +10 more
wiley   +1 more source

Nuclear Receptors Are Differentially Expressed and Activated in KAIMRC1 Compared to MCF7 and MDA-MB231 Breast Cancer Cells

Molecules, 2019
We recently established a KAIMRC1 cell line that has unique features compared to the known breast cancer cell lines, MCF7 and MDA-MB231. To characterize it further, we investigated the expression profile of nuclear receptors and their respective co ...
Atef Nehdi, Rizwan Ali, Alshaimaa Alhallaj, Hajar Alzahrani, Nosaibah Samman, Abdullah Mashhour, Omar Baz, Tlili Barhoumi, Bandar Alghanem, Abdullatif Khan, Lolwah Alriyees, Mohamed Boudjelal   +11 more
doaj   +1 more source

Expression of Retinoid X Receptors in Human Dermal Fibroblasts

Experimental Cell Research, 1997
Retinoic acid (RA) is known to exert profound effects on growth and differentiation in human dermal fibroblasts. In the observations presented here, we examined the regulation of expression of members of the RXR multigene family in human dermal fibroblasts.
Monica Peacocke, Hui C. Tsou, Xiao Li Ping, Xiao Xun Xie, Ya Juan Yao   +4 more
openaire   +3 more sources

Aerobic Exercise Attenuates Autophagy‐Lysosomal Flux Deficits via β2‐AR‐Mediated ESCRT‐III Subunit CHMP4B in Mice With Human MAPT P301L

Aging Cell, EarlyView.
MAPT accumulation inhibited CHMP4B expression and thus disrupted ESCRT‐III‐mediated autophagosome‐lysosome fusion, which induced a vicious cycle between MAPT aggregation and autophagic deficits. Aerobic exercise could effectively block the vicious cycle and reverse autophagic deficits by promoting the β2‐AR‐RXRα‐CHMP4B‐ESCRT‐III pathway, reducing ...
Shu‐Guang Bi, Haitao Yu, Tian‐Long Gao, Jia‐Jun Wu, Yu‐Ming Mao, Juan Gong, Fang‐Zhou Wang, Liu Yang, Jia Chen, Zi‐Chong Lan, Meng‐Ting Shen, Yun‐Juan Nie, Gao‐Shang Chai   +12 more
wiley   +1 more source

Synergistic potential of CDK4/6 inhibitors and ATRA in non‐APL AML

British Journal of Haematology, EarlyView.
Summary Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by diverse genetic abnormalities. The standard of care remains to be chemotherapy and stem cell transplantation. In acute promyelocytic leukaemia (APL), differentiation therapy with all‐trans retinoic acid (ATRA) has significantly improved outcomes. Despite this, the success
Rafał Skopek, Setenay Gupse Özcan, Paulina Chmiel, Stephanie Morgner, Jaqueline Schütt, Faezeh Ghazvini Zadegan, Clara Stanko, Małgorzata Palusińska, Karolina Maślińska‐Gromadka, Yordan Sbirkov, Sven Stengel, Martin Fischer, Annamaria Brioli, Arthur Zelent, Łukasz Szymański, Tino Schenk   +15 more
wiley   +1 more source

Role of Retinoid X Receptors (RXRs) and dietary vitamin A in Alzheimer's disease: Evidence from clinicopathological and preclinical studies. [PDF]

Neurobiol Dis, 2021
Biyong EF, Tremblay C, Leclerc M, Caron V, Alfos S, Helbling JC, Rodriguez L, Pernet V, Bennett DA, Pallet V, Calon F.   +10 more
europepmc   +1 more source

Implications for medication safety and adherence in dermato‐oncology: The AMBORA care program for oral antitumor therapeutics

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Dermatological oral antitumor therapeutics (OAT) are often interaction‐prone and used in complex regimens. The pharmacological/pharmaceutical care program of the randomized AMBORA trial significantly improved medication safety with various OAT; however, dermato‐oncological patients were not included.
Lisa Cuba, Frank Dörje, Rafaela Kramer, Pauline Dürr, Michael Erdmann, Martin F. Fromm, Carola Berking, Katja Gessner   +7 more
wiley   +1 more source

Structure–Activity Relationships and Therapeutic Applications of Retinoids in View of Potential Benefits from Drug Repurposing Process

Biomedicines
Vitamin A, an essential micronutrient, is integral to various biological processes crucial for organismal development and maintenance. Dietary sources of vitamin A encompass preformed retinol, retinyl esters, and provitamin A carotenoids.
Piotr Kawczak, Igor Feszak, Piotr Brzeziński, Tomasz Bączek   +3 more
doaj   +1 more source

Retinoid X receptors in the kidney: their protein expression and functional significance.

Endocrinology, 1997
Retinoid X receptors (RXRs) heterodimerize with 1,25-dihydroxyvitamin D3 (VD) receptor (VDR), and play important roles in VD-regulated transactivation. VD acts on many tissues including kidney for the regulation of calcium homeostasis. In the kidney, the
Akira Sugawara, N. Sanno, Nobuyuki Takahashi, R. Y. Osamura, Keishi Abe   +4 more
semanticscholar   +1 more source