Results 11 to 20 of about 122,450 (299)
Of Retinoids and Organotins: The Evolution of the Retinoid X Receptor in Metazoa [PDF]
Biomolecules, 2020 Nuclear receptors (NRs) are transcription factors accomplishing a multiplicity of functions, essential for organismal homeostasis. Among their numerous members, the retinoid X receptor (RXR) is a central player of the endocrine system, with a singular ability to operate as a homodimer or a heterodimer with other NRs. Additionally, RXR has been found to
Elza Fonseca +5 more
openaire +3 more sources
Retinoid X Receptor Antagonists [PDF]
International Journal of Molecular Sciences, 2018 Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use.
Masaki Watanabe, Hiroki Kakuta
openaire +3 more sources
Long-distance retinoid signaling in the zebra finch brain. [PDF]
PLoS ONE, 2014 All-trans retinoic acid (ATRA), the main active metabolite of vitamin A, is a powerful signaling molecule that regulates large-scale morphogenetic processes during vertebrate embryonic development, but is also involved post-natally in regulating neural ...
Tina C Roeske +4 more
doaj +1 more source
Retinoic Acid and Its Derivatives in Skin
Cells, 2020 The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are ...
Łukasz Szymański +8 more
doaj +1 more source
Scientific Reports, 2021 Retinoid X receptors are members of the nuclear receptor family that regulate gene expression in response to retinoic acid and related ligands. Group 1 metabotropic glutamate receptors are G-protein coupled transmembrane receptors that activate ...
Chirag Upreti +10 more
doaj +1 more source
Hepatology, EarlyView., 2022 Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim +12 more
wiley +1 more source
Retinoid X receptors: X-ploring their (patho)physiological functions [PDF]
Cell Death & Differentiation, 2004 Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription factors that regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as heterodimerization partner for their function. This places RXR in the crossroad of multiple distinct biological pathways.
A. Szántó +5 more
semanticscholar +4 more sources
Haematologica, 2021 RARA and RXRA contribute to myeloid maturation in both mice and humans, and deletion of Rxra and Rxrb augments leukemic growth in mice. While defining the domains of RXRA that are required for anti-leukemic effects in murine KMT2A-MLLT3 leukemia cells ...
Orsola di Martino +7 more
doaj +1 more source
DNA Bending by Retinoid X Receptor-Containing Retinoid and Thyroid Hormone Receptor Complexes [PDF]
Molecular and Cellular Biology, 1993 Retinoid X receptors (RXR) have been identified as common subunits in the regulation of multiple hormonal signaling pathways. Using circular permutation and phasing analysis of specific response elements, we present evidence that RXR-retinoic acid receptor and RXR-thyroid hormone receptor heterodimer or RXR-RXR homodimer complexes induce directed DNA ...
Xian Ping Lu +2 more
openaire +3 more sources
Role of retinoic receptors in lung carcinogenesis
Journal of Experimental & Clinical Cancer Research, 2008 Several in vitro and in vivo studies have examined the positive and negative effects of retinoids (vitamin A analogs) in premalignant and malignant lesions.
Renyi-Vamos Ferenc +4 more
doaj +1 more source