Results 21 to 30 of about 121,393 (276)

Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors

Scientific Reports, 2021
Retinoid X receptors are members of the nuclear receptor family that regulate gene expression in response to retinoic acid and related ligands. Group 1 metabotropic glutamate receptors are G-protein coupled transmembrane receptors that activate ...
Chirag Upreti, Caitlin M. Woodruff, Xiao-Lei Zhang, Michael J. Yim, Zhen-yu Zhou, Andrew M. Pagano, Dina S. Rehanian, Deqi Yin, Eric R. Kandel, Patric K. Stanton, Russell E. Nicholls   +10 more
doaj   +1 more source

RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells

Haematologica, 2021
RARA and RXRA contribute to myeloid maturation in both mice and humans, and deletion of Rxra and Rxrb augments leukemic growth in mice. While defining the domains of RXRA that are required for anti-leukemic effects in murine KMT2A-MLLT3 leukemia cells ...
Orsola di Martino, Margaret A. Ferris, Gayla Hadwiger, Soyi Sarkar, Anh Vu, María P. Menéndez-Gutiérrez, Mercedes Ricote, John S. Welch   +7 more
doaj   +1 more source

Role of retinoic receptors in lung carcinogenesis

Journal of Experimental & Clinical Cancer Research, 2008
Several in vitro and in vivo studies have examined the positive and negative effects of retinoids (vitamin A analogs) in premalignant and malignant lesions.
Renyi-Vamos Ferenc, Bogos Krisztina, Kovacs Gabor, Tovari Jozsef, Dome Balazs   +4 more
doaj   +1 more source

Retinoids and Cardiac Development

Journal of Developmental Biology, 2014
Retinoic acid (RA), a derivative of vitamin A, is involved in signal transduction during vertebrate organogenesis. Retinoids through binding to nuclear receptors called RA receptors (RARs) and retinoid X receptors (RXRs) regulate various processes during
Stéphane Zaffran, Nicolas El Robrini, Nicolas Bertrand   +2 more
doaj   +1 more source

AEG-1 Regulates Retinoid X Receptor and Inhibits Retinoid Signaling [PDF]

Cancer Research, 2014
Abstract Retinoid X receptor (RXR) regulates key cellular responses such as cell growth and development, and this regulation is frequently perturbed in various malignancies, including hepatocellular carcinoma (HCC). However, the molecule(s) that physically govern this deregulation are mostly unknown.
Jyoti, Srivastava, Chadia L, Robertson, Devaraja, Rajasekaran, Rachel, Gredler, Ayesha, Siddiq, Luni, Emdad, Nitai D, Mukhopadhyay, Shobha, Ghosh, Phillip B, Hylemon, Gregorio, Gil, Khalid, Shah, Deepak, Bhere, Mark A, Subler, Jolene J, Windle, Paul B, Fisher, Devanand, Sarkar   +15 more
openaire   +2 more sources

Modulatory effects of extract of Heinsia crinita against fructose/streptozotocin-induced oxidative stress in diabetic rat models

Heliyon, 2023
Oxidative stress plays a crucial role in the development of type 2 diabetes and the associated microvascular and cardiovascular complications. In the study, we have investigated the effects of Heinsia crinita (H.
Iwara A. Iwara, Eve O. Mboso, Oju R. Ibor, Kelvin Elot, Collin Igajah, Andem A. Bassey, Ofem E. Eteng, Bob I.A. Mgbeje, Godwin O. Igile, Mbeh U. Eteng, Augustine Arukwe   +10 more
doaj   +1 more source

Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals. [PDF]

PLoS ONE, 2017
Disruption of nuclear receptors, a transcription factor superfamily regulating gene expression in animals, is one proposed mechanism through which pollution causes effects in aquatic invertebrates.
Susanne Vogeler, Tamara S Galloway, Michail Isupov, Tim P Bean   +3 more
doaj   +1 more source

Nuclear receptors in neurodegenerative diseases

Neurobiology of Disease, 2014
Nuclear receptors have generated substantial interest in the past decade as potential therapeutic targets for the treatment of neurodegenerative disorders.
Rebecca Skerrett, Tarja Malm, Gary Landreth   +2 more
doaj   +1 more source

DNA Bending by Retinoid X Receptor-Containing Retinoid and Thyroid Hormone Receptor Complexes [PDF]

Molecular and Cellular Biology, 1993
Retinoid X receptors (RXR) have been identified as common subunits in the regulation of multiple hormonal signaling pathways. Using circular permutation and phasing analysis of specific response elements, we present evidence that RXR-retinoic acid receptor and RXR-thyroid hormone receptor heterodimer or RXR-RXR homodimer complexes induce directed DNA ...
X P, Lu, N L, Eberhardt, M, Pfahl
openaire   +2 more sources

Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity

Nature Communications, 2019
The type II nuclear receptors (NRs) and the retinoid X receptor (RXR) form heterodimeric transcription factors to regulate development, metabolism, and inflammation.
Ashley Penvose, Jessica L. Keenan, David Bray, Vijendra Ramlall, Trevor Siggers   +4 more
doaj   +1 more source