Results 21 to 30 of about 122,450 (299)

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

Proceedings of the National Academy of Sciences of the United States of America, 1993
The binding of endogenous retinoids and stereoisomers of retinoic acid (RA) to the retinoid nuclear receptors, RA receptor (RARs) and retinoid X receptors (RXRs), was characterized using nucleosol preparations from transiently transfected COS-1 cells ...
G. Allenby, MARIE-THERESE BOCQUELt, Michael SAUNDERSt, S. Kazmer, J. Speck, Michael ROSENBERGERf, A. Lovey, Philippe KASTNERt, J. Grippo, Pierre Chambont, A. Levin   +10 more
semanticscholar   +1 more source

Retinoids and Cardiac Development

Journal of Developmental Biology, 2014
Retinoic acid (RA), a derivative of vitamin A, is involved in signal transduction during vertebrate organogenesis. Retinoids through binding to nuclear receptors called RA receptors (RARs) and retinoid X receptors (RXRs) regulate various processes during
Stéphane Zaffran, Nicolas El Robrini, Nicolas Bertrand   +2 more
doaj   +1 more source

Phytanic Acid is a Retinoid X Receptor Ligand [PDF]

European Journal of Biochemistry, 1996
Metabolic defects in phytanic acid catabolism have been shown to be connected with a number of human diseases which can lead to lethal defects of the nervous system and other organs. These effects are probably a result of the very high accumulation of phytanic acid in tissues throughout the body, due to defects in phytanic acid oxidation, the ...
Siegfried Keidel, Christian M. Apfel, Peter K. Lemotte   +2 more
openaire   +3 more sources

Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals. [PDF]

PLoS ONE, 2017
Disruption of nuclear receptors, a transcription factor superfamily regulating gene expression in animals, is one proposed mechanism through which pollution causes effects in aquatic invertebrates.
Susanne Vogeler, Tamara S Galloway, Michail Isupov, Tim P Bean   +3 more
doaj   +1 more source

Auto-silencing by the retinoid X receptor

Journal of Molecular Biology, 1998
Gene transcription is often regulated by small ligands, enabling cells to respond to external and metabolic stimuli. Of particular interest are the mechanisms by which hydrophobic hormones modulate the transcriptional activities of proteins of the nuclear receptor superfamily.
Diane Dong, Sander Kersten, Wen yi Lee, Peter R. Reczek, Noa Noy   +4 more
openaire   +3 more sources

AEG-1 Regulates Retinoid X Receptor and Inhibits Retinoid Signaling [PDF]

Cancer Research, 2014
Abstract Retinoid X receptor (RXR) regulates key cellular responses such as cell growth and development, and this regulation is frequently perturbed in various malignancies, including hepatocellular carcinoma (HCC). However, the molecule(s) that physically govern this deregulation are mostly unknown.
Luni Emdad, Jolene J. Windle, Paul B. Fisher, Phillip B. Hylemon, Shobha Ghosh, Nitai D. Mukhopadhyay, Gregorio Gil, Khalid Shah, Jyoti Srivastava, Deepak Bhere, Ayesha Siddiq, Mark A. Subler, Chadia L. Robertson, Rachel Gredler, Devaraja Rajasekaran, Devanand Sarkar   +15 more
openaire   +3 more sources

Induced differentiation of acute myeloid leukemia cells by activation of Retinoid X and Liver X Receptors

Leukemia, 2013
Use of all-trans retinoic acid (ATRA) as a differentiation agent has been limited to acute promyelocytic leukemia (APL) as non-APL leukemias are insensitive to ATRA.
P. V. Sanchez, Spencer T. Glantz, S. Scotland, M. Kasner, M. Carroll   +4 more
semanticscholar   +1 more source

Combined Central Hypothyroidism and Adrenal Insufficiency Associated with Retinoic Acid Therapy for Cutaneous T-Cell Lymphoma

AACE Clinical Case Reports, 2022
Background/Objective: Although retinoid-associated central hypothyroidism has been reported on several occasions, there are very few studies on retinoid-associated central adrenal insufficiency.
Amanda Marino, MDCM, Isabella Albanese, MDCM, MSc, Stephanie Larose, MD, I. George Fantus, MDCM   +3 more
doaj  

Potential therapeutic roles of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer’s disease

Neural Regeneration Research, 2019
All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors and retinoid X receptors to activate specific signaling pathways ...
Bhaskar C Das, Somsankar Dasgupta, Swapan K Ray   +2 more
doaj   +1 more source

Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity

Nature Communications, 2019
The type II nuclear receptors (NRs) and the retinoid X receptor (RXR) form heterodimeric transcription factors to regulate development, metabolism, and inflammation.
Ashley Penvose, Jessica L. Keenan, David Bray, Vijendra Ramlall, Trevor Siggers   +4 more
doaj   +1 more source