Results 71 to 80 of about 120,627 (303)
Viral Infections and Systemic Lupus Erythematosus: New Players in an Old Story
Viruses, 2021 A causal link between viral infections and autoimmunity has been studied for a long time and the role of some viruses in the induction or exacerbation of systemic lupus erythematosus (SLE) in genetically predisposed patients has been proved. The strength
Marco Quaglia +4 more
doaj +1 more source
Genetic Engineering Methods in Primary T Cells
Advanced Therapeutics, EarlyView.Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley +1 more source
Tumorigenesis related to retroviral infections
Journal of Infection in Developing Countries, 2011 Retroviral infections are considered important risk factors for cancer development in humans since approximately 15-20% of cancer worldwide is caused by an infectious agent.
Maria Braoudaki +1 more
doaj +1 more source
Advanced Science, EarlyView.Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu +7 more
wiley +1 more source
Viruses, 2014 Advanced nucleic acid-based technologies are powerful research tools for novel virus discovery but need to be standardized for broader applications such as virus detection in biological products and clinical samples.
Lanyn P. Taliaferro +6 more
doaj +1 more source
Maraviroc: integration of a new antiretroviral drug class into clinical practice [PDF]
, 2008 Maraviroc (Pfizer's UK-427857, Selzentry or Celsentri outside the US) is the first agent in the new class of oral HIV-1 entry inhibitors to acquire FDA and EMEA approval.
Vandekerckhove, Linos +2 more
core +2 more sources
The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
Advanced Science, EarlyView.This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li +3 more
wiley +1 more source
The Diverse Roles of microRNAs at the Host–Virus Interface
Viruses, 2018 MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level. Through this activity, they are implicated in almost every cellular process investigated to date.
Annie Bernier, Selena M. Sagan
doaj +1 more source
Advanced Science, EarlyView.This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen +18 more
wiley +1 more source
DNA Confinement drives uncoating of the HIV Virus
, 2014 We present a model for the uncoating of the HIV virus driven by forces exerted on the protein shell of HIV generated by DNA ...
Bruinsma, Robijn, Rouzina, Ioulia
core +1 more source