Results 71 to 80 of about 124,737 (275)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Population dynamics of rhesus macaques and associated foamy virus in Bangladesh. [PDF]

, 2013
Foamy viruses are complex retroviruses that have been shown to be transmitted from nonhuman primates to humans. In Bangladesh, infection with simian foamy virus (SFV) is ubiquitous among rhesus macaques, which come into contact with humans in diverse ...
Andreina Pacheco, M, Barry, Peter A, Craig, Karen L, Engel, Gregory A, Escalante, Ananias A, Feeroz, Mostafa M, Jackson, Dana L, Jones-Engel, Lisa, Kamrul Hasan, M, Lee, Eun-Gyung, Lerche, Nicholas W, Levine, Kathryn L, Linial, Maxine L, Matsen Iv, Frederick A, Oh, Gunwha, Rabiul Alam, SM, Small, Christopher T, Soliven, Khanh, Wang, Xiaoxing, Yee, JoAnn L   +19 more
core   +1 more source

Retroviruses and Autoimmunity.

Internal Medicine, 2001
The investigation of human retroviruses has shown dramatic progress since the discovery of human immunodeficiency virus (HIV). These studies have also contributed to the exploration of the role of retroviruses, including endogenous retroviruses, in the induction of autoimmune diseases such as systemic lupus erythematosus (SLE).
I, Sekigawa, H, Ogasawara, H, Kaneko, T, Hishikawa, H, Hashimoto   +4 more
openaire   +3 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Domestic chickens activate a piRNA defense against avian leukosis virus [PDF]

, 2017
PIWI-interacting RNAs (piRNAs) protect the germ line by targeting transposable elements (TEs) through the base-pair complementarity. We do not know how piRNAs co-evolve with TEs in chickens.
Anai, Aravin, Aravin, Aravin, Assis, Baluda, Bao, Bartel, Benkel, Bolisetty, Boyce-Jacino, Boyce-Jacino, Brawand, Brennecke, Carmell, Cenik, Cenik, Chen, Chirn, Crittenden, Dempster, Eickbush, Eriksson, Fadly, Fagegaltier, Farazi, Feschotte, Flemr, Frisby, Frost, Gao, Ghildiyal, Gifford, Goic, Gunawardane, Guo, Haas, Han, Hayward, Houwing, Houwing, Ingolia, Ingolia, International Chicken Genome Sequencing Consortium, Johnson, Jurka, Ka, Ka, Khurana, Kim, Kohany, Kojima, Kuhnlein, Kumar, Kumar, Kuramochi-Miyagawa, Kuramochi-Miyagawa, Lee, Levin, Lewinski, Li, Li, Li, Lim, Lin, Lu, Malik, Malone, McClintock, Meunier, Moore, Nawrocki, Necsulea, Oh, Paradis, Peirson, Pelechano, Reuter, Reuter, Ricci, Roberts, Robinson, Rosenkranz, Rutherford, Sacco, Saxe, Schlötterer, Shoji, Smit, Smith, Smith, Smith, Smith, Soper, Stehelin, Steitz, Stoye, Sumiyoshi, Tam, Tanaka, Tarlinton, Team, Temin, Tereba, Thompson, Thomson, Trapnell, Trapnell, Vandergon, Varmus, Wang, Wang, Watanabe, Weiss, Weiss, Weiss, West, Wichert, Wicker, Wilson, Yabuta, Zhang, Zhang, Zheng, Zhuang   +124 more
core   +2 more sources

Targeting the Mapk13‐Tcf1‐Slc7a5 Axis via One‐Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy

Advanced Science, EarlyView.
This study emphasizes the role of the Mapk13‐Tcf1‐Slc7a5‐methionine metabolism axis in stem‐like CD4+ T cells. Moreover, it uncovers the mechanism through which limiting one‐carbon metabolism in CD4+ stem‐like T cells suppresses the tide of chronic allograft vasculopathy, offering potential targets to promote long‐term graft survival.
Wang Yi, Di Wu, Jing Liu, Shi Chen, Liu Song, Bin Xie, Aini Xie, Peixiang Lan, Zhishui Chen   +8 more
wiley   +1 more source

DNA Confinement drives uncoating of the HIV Virus

, 2014
We present a model for the uncoating of the HIV virus driven by forces exerted on the protein shell of HIV generated by DNA ...
Bruinsma, Robijn, Rouzina, Ioulia
core   +1 more source

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source