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Unlocking influenza B: exploring molecular biology and reverse genetics for epidemic control and vaccine innovation [PDF]
Virology JournalInfluenza is a highly contagious acute viral illness that affects the respiratory system, posing a significant global public health concern. Influenza B virus (IBV) causes annual seasonal epidemics.
Ghayyas Ud Din +10 more
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Plasmid DNA-based reverse genetics as a platform for manufacturing of bluetongue vaccine [PDF]
Journal of VirologyControl of bluetongue disease is predominantly through vaccination with licensed inactivated or live-attenuated vaccines (LAVs). Manufacturing of LAVs in endemic countries requires formulation with a high number of serotypes for effective protection ...
Tendai A. M. Mlingo +2 more
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Reverse genetics in virology: A double edged sword
Biosafety and Health, 2022 Reverse genetics via targeted modification of gene sequences to obtain a phenotype and the inference of a gene's function or regulatory mechanism is widely used as a potent tool in viral biology and application.
Hongyu Chen, Hongqi Liu, Xiaozhong Peng
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Human Rotavirus Reverse Genetics Systems to Study Viral Replication and Pathogenesis
Viruses, 2021 Human rotaviruses (HuRVAs) are highly important causes of acute gastroenteritis in infants and young children worldwide. A lack of reliable and reproducible reverse genetics systems for HuRVAs has limited a proper understanding of HuRVA biology and also ...
Satoshi Komoto +3 more
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Reverse genetics rescue of sylvatic dengue viruses [PDF]
Journal of VirologyThere are an unknown number of sylvatic (“sylvan” = “of the forest”) dengue viruses currently being sustained by nonhuman primates and mosquitoes in the forests of Africa and Asia.
Paul Gendler +6 more
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Engineering Nipah virus: Reverse genetics as a gateway to novel drug discovery [PDF]
New Microbes and New InfectionsNipah virus (NiV) is a highly pathogenic and re-emerging virus that requires containment in biosafety level 4 (BSL-4) laboratories. The limited accessibility of these high-security facilities poses major obstacles to investigating immunopathogenesis and ...
Muralidharan Menon Arjun +1 more
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Simple reverse genetics approach to elucidating the biosynthetic pathway of complex thiopeptide nocathiacin [PDF]
, 2010 Biothythetic pathway of the most drugable thiopeptide nocathiacin has been elucidated by applying reverse genetics method based on its structural features.
Jing Deng +4 more
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Highs and Lows in Calicivirus Reverse Genetics [PDF]
VirusesIn virology, the term reverse genetics refers to a set of methodologies in which changes are introduced into the viral genome and their effects on the generation of infectious viral progeny and their phenotypic features are assessed.
Ángel L. Álvarez +7 more
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Marburg Virus Reverse Genetics Systems [PDF]
Viruses, 2016 The highly pathogenic Marburg virus (MARV) is a member of the Filoviridae family and belongs to the group of nonsegmented negative-strand RNA viruses.
Kristina Maria Schmidt, Elke Mühlberger
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Reverse genetics in ecological research.
PLoS ONE, 2008 By precisely manipulating the expression of individual genetic elements thought to be important for ecological performance, reverse genetics has the potential to revolutionize plant ecology.
Jens Schwachtje +2 more
doaj +5 more sources