Results 1 to 10 of about 191,346 (272)

Delta-Catenin as a Modulator of Rho GTPases in Neurons [PDF]

Frontiers in Cellular Neuroscience, 2022
Small Rho GTPases are molecular switches that are involved in multiple processes including regulation of the actin cytoskeleton. These GTPases are activated (turned on) and inactivated (turned off) through various upstream effector molecules to carry out
Maxsam S. Donta, Maxsam S. Donta, Yogesh Srivastava, Pierre D. McCrea, Pierre D. McCrea, Pierre D. McCrea   +5 more
doaj   +2 more sources

Rho GTPases in Model Systems [PDF]

Cells, 2023
Since the discovery of their role in the regulation of actin cytoskeleton 30 years ago, Rho GTPases have taken center stage in cell motility research [...]
Vedrana Filić, Igor Weber
doaj   +2 more sources

Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses

Cells, 2020
Rho GTPases, a family of the Ras GTPase superfamily, are key regulators of the actin cytoskeleton. They were originally thought to primarily affect cell migration and invasion; however, recent advances in our understanding of the biology and function of ...
Brock Humphries, Zhishan Wang, Chengfeng Yang   +2 more
doaj   +2 more sources

Dahuang—Taoren, a botanical drug combination, ameliorates adenomyosis via inhibiting Rho GTPases [PDF]

Frontiers in Pharmacology, 2023
Introduction: Dahuang-Taoren (DT) is a classic combination of botanical drugs applied to treat pain-related diseases in ancient China. Today, DT is frequently applied for dysmenorrhea of adenomyosis (AM) in the clinic.
Ya Lei, Ya Lei, Xianyun Fu, Minmin Chen, Yongli Yi, Ping Mao, Li Peng, Zhao Qu   +7 more
doaj   +2 more sources

The potential therapeutic roles of Rho GTPases in substance dependence [PDF]

Frontiers in Molecular Neuroscience, 2023
Rho GTPases family are considered to be molecular switches that regulate various cellular processes, including cytoskeleton remodeling, cell polarity, synaptic development and maintenance.
Qin Ru, Yu Wang, Enyuan Zhou, Lin Chen, Yuxiang Wu   +4 more
doaj   +2 more sources

Role of Rho GTPases in inflammatory bowel disease [PDF]

Cell Death Discovery, 2023
Rat sarcoma virus homolog (Rho) guanosine triphosphatases (GTPases) function as “molecular switch” in cellular signaling regulation processes and are associated with the pathogenesis of inflammatory bowel disease (IBD).
Xiaoling Li, Mudan Zhang, Gaoshi Zhou, Zhuo Xie, Ying Wang, Jing Han, Li Li, Qirui Wu, Shenghong Zhang   +8 more
doaj   +2 more sources

Rho GTPases in kidney physiology and diseases. [PDF]

Small GTPases, 2022
Rho family GTPases are molecular switches best known for their pivotal role in dynamic regulation of the actin cytoskeleton, but also of cellular morphology, motility, adhesion and proliferation.
Steichen C, Hervé C, Hauet T, Bourmeyster N.   +3 more
europepmc   +2 more sources

Rho GTPases—Emerging Regulators of Glucose Homeostasis and Metabolic Health

Cells, 2019
Rho guanosine triphosphatases (GTPases) are key regulators in a number of cellular functions, including actin cytoskeleton remodeling and vesicle traffic.
Lisbeth Liliendal Valbjørn Møller, Amira Klip, Lykke Sylow   +2 more
doaj   +2 more sources

Dysregulation of Rho GTPases in Human Cancers. [PDF]

Cancers (Basel), 2020
Rho GTPases play central roles in numerous cellular processes, including cell motility, cell polarity, and cell cycle progression, by regulating actin cytoskeletal dynamics and cell adhesion.
Jung H, Yoon SR, Lim J, Cho HJ, Lee HG.
europepmc   +2 more sources

Rho GTPases as therapeutic targets in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2017
The progress we have made in understanding Alzheimer’s disease (AD) pathogenesis has led to the identification of several novel pathways and potential therapeutic targets.
Byron J. Aguilar, Yi Zhu, Qun Lu
doaj   +2 more sources