Rho GTPases in Model Systems [PDF]
Cells, 2023 Since the discovery of their role in the regulation of actin cytoskeleton 30 years ago, Rho GTPases have taken center stage in cell motility research [...]
Vedrana Filić, Igor Weber
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Delta-Catenin as a Modulator of Rho GTPases in Neurons [PDF]
Frontiers in Cellular Neuroscience, 2022 Small Rho GTPases are molecular switches that are involved in multiple processes including regulation of the actin cytoskeleton. These GTPases are activated (turned on) and inactivated (turned off) through various upstream effector molecules to carry out
Maxsam S. Donta +5 more
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The potential therapeutic roles of Rho GTPases in substance dependence [PDF]
Frontiers in Molecular Neuroscience, 2023 Rho GTPases family are considered to be molecular switches that regulate various cellular processes, including cytoskeleton remodeling, cell polarity, synaptic development and maintenance.
Qin Ru +4 more
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Dahuang—Taoren, a botanical drug combination, ameliorates adenomyosis via inhibiting Rho GTPases [PDF]
Frontiers in Pharmacology, 2023 Introduction: Dahuang-Taoren (DT) is a classic combination of botanical drugs applied to treat pain-related diseases in ancient China. Today, DT is frequently applied for dysmenorrhea of adenomyosis (AM) in the clinic.
Ya Lei +7 more
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Role of Rho GTPases in inflammatory bowel disease [PDF]
Cell Death Discovery, 2023 Rat sarcoma virus homolog (Rho) guanosine triphosphatases (GTPases) function as “molecular switch” in cellular signaling regulation processes and are associated with the pathogenesis of inflammatory bowel disease (IBD).
Xiaoling Li +8 more
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Rho-GTPases subfamily: cellular defectors orchestrating viral infection [PDF]
Cellular & Molecular Biology LettersRas homolog gene family-guanosine triphosphatases (Rho-GTPases), key molecular switches regulating cytoskeletal dynamics and cellular signaling, play a pivotal role in viral infections by modulating critical processes such as viral entry, replication ...
Beibei Zhang +5 more
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The Multiple Functions of Rho GTPases in Fission Yeasts [PDF]
Cells, 2021 The Rho family of GTPases represents highly conserved molecular switches involved in a plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has become a fundamental model organism to study the functions of Rho GTPases over the ...
Jero Vicente-Soler +4 more
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TRP Channels Regulation of Rho GTPases in Brain Context and Diseases [PDF]
Frontiers in Cell and Developmental Biology, 2020 Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood ...
Boris Lavanderos +12 more
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Aberrant activation of TGF-β1 induces high bone turnover via Rho GTPases-mediated cytoskeletal remodeling in Camurati-Engelmann disease [PDF]
Frontiers in Endocrinology, 2022 In the adult skeleton, the bone remodeling process involves a dynamic coordination between osteoblasts and osteoclasts, which is disrupted in diseases with high bone turnover rates and dysregulated transforming growth factor beta 1 (TGF-β1).
Qi Chen +19 more
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A computational analysis of the role of integrins and Rho-GTPases in the emergence and disruption of apical-basal polarization in renal epithelial cells. [PDF]
PLoS Computational BiologyApical-basal polarization in renal epithelial cells is crucial to renal function and an important trigger for tubule formation in kidney development.
Maria J Hagelaars +5 more
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