The Multiple Functions of Rho GTPases in Fission Yeasts [PDF]
Cells, 2021 The Rho family of GTPases represents highly conserved molecular switches involved in a plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has become a fundamental model organism to study the functions of Rho GTPases over the ...
Jero Vicente-Soler +4 more
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Rho-GTPases subfamily: cellular defectors orchestrating viral infection [PDF]
Cellular & Molecular Biology LettersRas homolog gene family-guanosine triphosphatases (Rho-GTPases), key molecular switches regulating cytoskeletal dynamics and cellular signaling, play a pivotal role in viral infections by modulating critical processes such as viral entry, replication ...
Beibei Zhang +5 more
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TRP Channels Regulation of Rho GTPases in Brain Context and Diseases [PDF]
Frontiers in Cell and Developmental Biology, 2020 Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood ...
Boris Lavanderos +12 more
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Aberrant activation of TGF-β1 induces high bone turnover via Rho GTPases-mediated cytoskeletal remodeling in Camurati-Engelmann disease [PDF]
Frontiers in Endocrinology, 2022 In the adult skeleton, the bone remodeling process involves a dynamic coordination between osteoblasts and osteoclasts, which is disrupted in diseases with high bone turnover rates and dysregulated transforming growth factor beta 1 (TGF-β1).
Qi Chen +19 more
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A computational analysis of the role of integrins and Rho-GTPases in the emergence and disruption of apical-basal polarization in renal epithelial cells. [PDF]
PLoS Computational BiologyApical-basal polarization in renal epithelial cells is crucial to renal function and an important trigger for tubule formation in kidney development.
Maria J Hagelaars +5 more
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Regulation of Rho GTPases by RhoGDIs in Human Cancers
Cells, 2019 Rho GDP dissociation inhibitors (RhoGDIs) play important roles in various cellular processes, including cell migration, adhesion, and proliferation, by regulating the functions of the Rho GTPase family.
Hee Jun Cho +4 more
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Role of Rho GTPases in stem cell regulation. [PDF]
Biochem Soc Trans, 2021 Zhang Z, Liu M, Zheng Y.
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The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells
Analytical Cellular Pathology, 2020 Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain parenchyma. The Rho family of small GTPases, which includes Rac1, Cdc42, and RhoA,
Houssam Al-Koussa +4 more
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MLL regulates the actin cytoskeleton and cell migration by stabilising Rho GTPases via the expression of RhoGDI1. [PDF]
J Cell Sci, 2022 Chinchole A, Lone KA, Tyagi S.
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Regulation of Rho GTPases in the Vasculature by Cullin3-Based E3 Ligase Complexes [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cullin3-based ubiquitin E3 ligases induce ubiquitination of substrates leading to their proteasomal or lysosomal degradation. BTB proteins serve as adaptors by binding to Cullin3 and recruiting substrate proteins, which enables specific recognition of a ...
Fabienne Podieh, Peter L. Hordijk
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