Results 11 to 20 of about 72,889 (250)
Regulation of Rho GTPases in the Vasculature by Cullin3-Based E3 Ligase Complexes [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cullin3-based ubiquitin E3 ligases induce ubiquitination of substrates leading to their proteasomal or lysosomal degradation. BTB proteins serve as adaptors by binding to Cullin3 and recruiting substrate proteins, which enables specific recognition of a ...
Fabienne Podieh, Peter L. Hordijk
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Structural Dynamics of Rho GTPases. [PDF]
J Mol BiolRho family GTPases are a part of the Ras superfamily and are signaling hubs for many cellular processes. While the detailed understanding of Ras structure and function has led to tremendous progress in oncogenic Ras-targeted drug discovery, studies of the related Rho GTPases are still catching up as the recurrent cancer-related Rho GTPase mutations ...
Lin Y, Zheng Y.
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Rho GTPases in ameloblast differentiation
Japanese Dental Science Review, 2016 During tooth development, ameloblasts differentiate from inner enamel epithelial cells to enamel-forming cells by modulating the signal pathways mediating epithelial–mesenchymal interaction and a cell-autonomous gene network.
Keishi Otsu, Hidemitsu Harada
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Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]
, 2013 Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Amann, Kerstin +13 more
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Rho GTPase signaling in rheumatic diseases
iScience, 2022 Summary: Rho guanosine triphosphatase (GTPases), as molecular switches, have been identified to be dysregulated and involved in the pathogenesis of various rheumatic diseases, mainly including rheumatoid arthritis, osteoarthritis, systemic sclerosis, and
Ruijie Zeng +4 more
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Pharmacological Modulators of Small GTPases of Rho Family in Neurodegenerative Diseases
Frontiers in Cellular Neuroscience, 2021 Classical Rho GTPases, including RhoA, Rac1, and Cdc42, are members of the Ras small GTPase superfamily and play essential roles in a variety of cellular functions.
William Guiler +3 more
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Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses
Cells, 2020 Rho GTPases, a family of the Ras GTPase superfamily, are key regulators of the actin cytoskeleton. They were originally thought to primarily affect cell migration and invasion; however, recent advances in our understanding of the biology and function of ...
Brock Humphries +2 more
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Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity
Frontiers in Cardiovascular Medicine, 2022 Platelet cytoskeletal reorganisation is a critical component of platelet activation and thrombus formation in haemostasis. The Rho GTPases RhoA, Rac1 and Cdc42 are the primary drivers in the dynamic reorganisation process, leading to the development of ...
Shane P. Comer, Shane P. Comer
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Small GTPases, 2012 In his review of the Ras family in 1988, Pierre Chardin speculated that an obscure subfamily of the Ras superfamily, which at that time was only known in yeast, would be conserved in mammals.1 He was of course right, and today the number of labs and the amount of effort being expended to understand the vast network of Rho-family signaling is enormous ...
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High Throughput strategies Aimed at Closing the GAP in Our Knowledge of Rho GTPase Signaling
Cells, 2020 Since their discovery, Rho GTPases have emerged as key regulators of cytoskeletal dynamics. In humans, there are 20 Rho GTPases and more than 150 regulators that belong to the RhoGEF, RhoGAP, and RhoGDI families.
Manel Dahmene +2 more
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