Mechanosensitive stem cell fate choice is instructed by dynamic fluctuations in activation of Rho GTPases. [PDF]
Proc Natl Acad Sci U S A, 2023 Sampayo RG +4 more
europepmc +3 more sources
Rho GTPases in the Physiology and Pathophysiology of Peripheral Sensory Neurons
Cells, 2019 Numerous experimental studies demonstrate that the Ras homolog family of guanosine triphosphate hydrolases (Rho GTPases) Ras homolog family member A (RhoA), Ras-related C3 botulinum toxin substrate 1 (Rac1) and cell division cycle 42 (Cdc42) are ...
Theodora Kalpachidou +3 more
doaj +2 more sources
Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases [PDF]
Cells, 2021 Rho proteins operate as key regulators of the cytoskeleton, cell morphology and trafficking. Acting as molecular switches, the function of Rho GTPases is determined by guanosine triphosphate (GTP)/guanosine diphosphate (GDP) exchange and their lipidation
Rashmita Pradhan +4 more
doaj +2 more sources
Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases
Cells, 2019 As membrane-associated master regulators of cytoskeletal remodeling, Rho GTPases coordinate a wide range of biological processes such as cell adhesion, motility, and polarity.
Monilola A. Olayioye +2 more
doaj +2 more sources
The Role of Rho GTPases in Toxicity of Clostridium difficile Toxins
Toxins, 2015 Clostridium difficile (C. difficile) is the main cause of antibiotic-associated diarrhea prevailing in hospital settings. In the past decade, the morbidity and mortality of C.
Shuyi Chen +3 more
doaj +2 more sources
Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPasesin vitro [PDF]
, 2022 Koch D +7 more
europepmc +2 more sources
Rho GTPase signaling in rheumatic diseases
iScience, 2022 Summary: Rho guanosine triphosphatase (GTPases), as molecular switches, have been identified to be dysregulated and involved in the pathogenesis of various rheumatic diseases, mainly including rheumatoid arthritis, osteoarthritis, systemic sclerosis, and
Ruijie Zeng +4 more
doaj +1 more source
Pharmacological Modulators of Small GTPases of Rho Family in Neurodegenerative Diseases
Frontiers in Cellular Neuroscience, 2021 Classical Rho GTPases, including RhoA, Rac1, and Cdc42, are members of the Ras small GTPase superfamily and play essential roles in a variety of cellular functions.
William Guiler +3 more
doaj +1 more source
Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity
Frontiers in Cardiovascular Medicine, 2022 Platelet cytoskeletal reorganisation is a critical component of platelet activation and thrombus formation in haemostasis. The Rho GTPases RhoA, Rac1 and Cdc42 are the primary drivers in the dynamic reorganisation process, leading to the development of ...
Shane P. Comer, Shane P. Comer
doaj +1 more source
High Throughput strategies Aimed at Closing the GAP in Our Knowledge of Rho GTPase Signaling
Cells, 2020 Since their discovery, Rho GTPases have emerged as key regulators of cytoskeletal dynamics. In humans, there are 20 Rho GTPases and more than 150 regulators that belong to the RhoGEF, RhoGAP, and RhoGDI families.
Manel Dahmene +2 more
doaj +1 more source