Results 1 to 10 of about 139,231 (236)

The sphere organelle contains small nuclear ribonucleoproteins. [PDF]

Proceedings of the National Academy of Sciences, 1989
We show by immunofluorescence microscopy of amphibian oocyte nuclei that small nuclear ribonucleoproteins (snRNPs) occur in lampbrush chromosome loops, in a few dozen extrachromosomal organelles previously described as "spheres," and in thousands of smaller granules.
Joseph G. Gall, Haroldg . Callan
core   +6 more sources

New insights into trypanosomatid U5 small nuclear ribonucleoproteins [PDF]

Memórias do Instituto Oswaldo Cruz, 2011
Several protozoan parasites exist in the Trypanosomatidae family, including various agents of human diseases. Multiple lines of evidence suggest that important differences are present between the translational and mRNA processing (trans splicing) systems of trypanosomatids and other eukaryotes.
da Silva, Marco Tulio A., Ambrosio, Daniela L., Trevelin, Caroline C., Watanabe, Tatiana F., Laure, Helen J., Greene, Lewis J., Rosa, Jose C., Valentini, Sandro Roberto, Cicarelli, Regina Maria Barretto   +8 more
openaire   +7 more sources

PRP4: a Protein of the Yeast U4/U6 Small Nuclear Ribonucleoprotein Particle [PDF]

Molecular and Cellular Biology, 1989
The Saccharomyces cerevisiae prp mutants (prp2 through prp11) are known to be defective in pre-mRNA splicing at nonpermissive temperatures. We have sequenced the PRP4 gene and shown that it encodes a 52-kilodalton protein. We obtained PRP4 protein-specific antibodies and found that they inhibited in vitro pre-mRNA splicing, which confirms the essential
Banroques, Josette, Abelson, John N.
openaire   +8 more sources

Spliceosomal snRNA Epitranscriptomics

Frontiers in Genetics, 2021
Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell ...
Pedro Morais, Hironori Adachi, Yi-Tao Yu
doaj   +1 more source

Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder

Nature Communications, 2021
GEMIN5, an RNA-binding protein, is required for formation of small nuclear ribonucleoproteins. Here, the authors identify loss of function mutations in GEMIN5 that are associated with a human neurodevelopmental disorder.
Sukhleen Kour, Deepa S. Rajan, Tyler R. Fortuna, Eric N. Anderson, Caroline Ward, Youngha Lee, Sangmoon Lee, Yong Beom Shin, Jong-Hee Chae, Murim Choi, Karine Siquier, Vincent Cantagrel, Jeanne Amiel, Elliot S. Stolerman, Sarah S. Barnett, Margot A. Cousin, Diana Castro, Kimberly McDonald, Brian Kirmse, Andrea H. Nemeth, Dhivyaa Rajasundaram, A. Micheil Innes, Danielle Lynch, Patrick Frosk, Abigail Collins, Melissa Gibbons, Michele Yang, Isabelle Desguerre, Nathalie Boddaert, Cyril Gitiaux, Siri Lynne Rydning, Kaja K. Selmer, Roser Urreizti, Alberto Garcia-Oguiza, Andrés Nascimento Osorio, Edgard Verdura, Aurora Pujol, Hannah R. McCurry, John E. Landers, Sameer Agnihotri, E. Corina Andriescu, Shade B. Moody, Chanika Phornphutkul, Maria J. Guillen Sacoto, Amber Begtrup, Henry Houlden, Janbernd Kirschner, David Schorling, Sabine Rudnik-Schöneborn, Tim M. Strom, Steffen Leiz, Kali Juliette, Randal Richardson, Ying Yang, Yuehua Zhang, Minghui Wang, Jia Wang, Xiaodong Wang, Konrad Platzer, Sandra Donkervoort, Carsten G. Bönnemann, Matias Wagner, Mahmoud Y. Issa, Hasnaa M. Elbendary, Valentina Stanley, Reza Maroofian, Joseph G. Gleeson, Maha S. Zaki, Jan Senderek, Udai Bhan Pandey   +69 more
doaj   +1 more source

High Throughput FISH Screening Identifies Small Molecules That Modulate Oncogenic lncRNA MALAT1 via GSK3B and hnRNPs

Non-Coding RNA, 2023
Traditionally, small molecule-based drug discovery has mainly focused on proteins as the drug target. Opening RNA as an additional target space for small molecules offers the possibility to therapeutically modulate disease-driving non-coding RNA targets ...
Nina Zablowsky, Lydia Farack, Sven Rofall, Jan Kramer, Hanna Meyer, Duy Nguyen, Alexander K. C. Ulrich, Benjamin Bader, Patrick Steigemann   +8 more
doaj   +1 more source

The assembly of a spliceosomal small nuclear ribonucleoprotein particle [PDF]

Nucleic Acids Research, 2008
The U1, U2, U4, U5 and U6 small nuclear ribonucleoprotein particles (snRNPs) are essential elements of the spliceosome, the enzyme that catalyzes the excision of introns and the ligation of exons to form a mature mRNA. Since their discovery over a quarter century ago, the structure, assembly and function of spliceosomal snRNPs have been extensively ...
Snehal Bhikhu Patel, Michel Bellini
openaire   +3 more sources

Reconstitution of the U1 small nuclear ribonucleoprotein particle. [PDF]

Molecular and Cellular Biology, 1987
Although the U1 small nuclear ribonucleoprotein particle (snRNP) was the first mRNA-splicing cofactor to be identified, the manner in which it functions in splicing is not precisely understood. Among the information required to understand how U1 snRNP participates in splicing, it will be necessary to know its structure.
J R Patton, T Pederson, R J Patterson
openaire   +4 more sources

Cajal body proteins differentially affect the processing of box C/D scaRNPs. [PDF]

PLoS ONE, 2015
Small nuclear ribonucleoproteins (snRNPs), which are required for pre-mRNA splicing, contain extensively modified snRNA. Small Cajal body-specific ribonucleoproteins (scaRNPs) mediate these modifications.
Isioma I Enwerem, Guowei Wu, Yi Tao Yu, Michael D Hebert   +3 more
doaj   +1 more source

Small nuclear ribonucleoprotein complexes of Drosophila melanogaster. [PDF]

Proceedings of the National Academy of Sciences, 1982
We report here on the isolation and characterization of small nuclear ribonucleoproteins (snRNPs) and corresponding small nuclear RNA (snRNA) species from nuclei of Drosophila melanogaster. Velocity sedimentation in sucrose gradients was used to partially fractionate the RNPs; analysis of fractions so obtained suggests that, in general, one snRNP ...
Su-Yun Chung, Roger D. Cone, John C. Wooley, David Tartof   +3 more
openaire   +3 more sources