Results 1 to 10 of about 25,036 (270)

New insights into trypanosomatid U5 small nuclear ribonucleoproteins [PDF]

Memorias do Instituto Oswaldo Cruz, 2011
Several protozoan parasites exist in the Trypanosomatidae family, including various agents of human diseases. Multiple lines of evidence suggest that important differences are present between the translational and mRNA processing (trans splicing) systems
Marco Túlio A da Silva, Daniela L Ambrósio, Caroline C Trevelin, Tatiana F Watanabe, Helen J Laure, Lewis J Greene, José C Rosa, Sandro R Valentini, Regina MB Cicarelli   +8 more
doaj   +5 more sources

Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies [PDF]

BMC Cell Biology, 2009
Background Active pre-mRNA splicing occurs co-transcriptionally, and takes place throughout the nucleoplasm of eukaryotic cells. Splicing decisions are controlled by networks of nuclear RNA-binding proteins and their target sequences, sometimes in ...
Bindereif Albrecht, Clark Emma L, Emami Kaveh, Heiner Monika, Bourgeois Cyril F, Dalgliesh Caroline, Rajan Prabhakar, Stevenin James, Robson Craig N, Leung Hing Y, Elliott David J   +10 more
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Spliceosomal snRNA Epitranscriptomics

Frontiers in Genetics, 2021
Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell ...
Pedro Morais, Hironori Adachi, Yi-Tao Yu
doaj   +1 more source

Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder

Nature Communications, 2021
GEMIN5, an RNA-binding protein, is required for formation of small nuclear ribonucleoproteins. Here, the authors identify loss of function mutations in GEMIN5 that are associated with a human neurodevelopmental disorder.
Sukhleen Kour, Deepa S. Rajan, Tyler R. Fortuna, Eric N. Anderson, Caroline Ward, Youngha Lee, Sangmoon Lee, Yong Beom Shin, Jong-Hee Chae, Murim Choi, Karine Siquier, Vincent Cantagrel, Jeanne Amiel, Elliot S. Stolerman, Sarah S. Barnett, Margot A. Cousin, Diana Castro, Kimberly McDonald, Brian Kirmse, Andrea H. Nemeth, Dhivyaa Rajasundaram, A. Micheil Innes, Danielle Lynch, Patrick Frosk, Abigail Collins, Melissa Gibbons, Michele Yang, Isabelle Desguerre, Nathalie Boddaert, Cyril Gitiaux, Siri Lynne Rydning, Kaja K. Selmer, Roser Urreizti, Alberto Garcia-Oguiza, Andrés Nascimento Osorio, Edgard Verdura, Aurora Pujol, Hannah R. McCurry, John E. Landers, Sameer Agnihotri, E. Corina Andriescu, Shade B. Moody, Chanika Phornphutkul, Maria J. Guillen Sacoto, Amber Begtrup, Henry Houlden, Janbernd Kirschner, David Schorling, Sabine Rudnik-Schöneborn, Tim M. Strom, Steffen Leiz, Kali Juliette, Randal Richardson, Ying Yang, Yuehua Zhang, Minghui Wang, Jia Wang, Xiaodong Wang, Konrad Platzer, Sandra Donkervoort, Carsten G. Bönnemann, Matias Wagner, Mahmoud Y. Issa, Hasnaa M. Elbendary, Valentina Stanley, Reza Maroofian, Joseph G. Gleeson, Maha S. Zaki, Jan Senderek, Udai Bhan Pandey   +69 more
doaj   +1 more source

High Throughput FISH Screening Identifies Small Molecules That Modulate Oncogenic lncRNA MALAT1 via GSK3B and hnRNPs

Non-Coding RNA, 2023
Traditionally, small molecule-based drug discovery has mainly focused on proteins as the drug target. Opening RNA as an additional target space for small molecules offers the possibility to therapeutically modulate disease-driving non-coding RNA targets ...
Nina Zablowsky, Lydia Farack, Sven Rofall, Jan Kramer, Hanna Meyer, Duy Nguyen, Alexander K. C. Ulrich, Benjamin Bader, Patrick Steigemann   +8 more
doaj   +1 more source

Cajal body proteins differentially affect the processing of box C/D scaRNPs. [PDF]

PLoS ONE, 2015
Small nuclear ribonucleoproteins (snRNPs), which are required for pre-mRNA splicing, contain extensively modified snRNA. Small Cajal body-specific ribonucleoproteins (scaRNPs) mediate these modifications.
Isioma I Enwerem, Guowei Wu, Yi Tao Yu, Michael D Hebert   +3 more
doaj   +1 more source

Principles and correction of 5’-splice site selection

RNA Biology, 2022
In Eukarya, immature mRNA transcripts (pre-mRNA) often contain coding sequences, or exons, interleaved by non-coding sequences, or introns. Introns are removed upon splicing, and further regulation of the retained exons leads to alternatively spliced ...
Florian Malard, Cameron D Mackereth, Sébastien Campagne   +2 more
doaj   +1 more source

PHF5A promotes colorectal cancerprogression by alternative splicing of TEAD2

Molecular Therapy: Nucleic Acids, 2021
Dysregulated alternative splicing (AS) plays critical roles in driving cancer progression, and the underlying mechanisms remain largely unknown. Here, we demonstrated that PHF5A, a component of U2 small nuclear ribonucleoproteins, was frequently ...
Yue Chang, Yulu Zhao, Liya Wang, Meijuan Wu, Chenglong He, Mengxi Huang, Zengjie Lei, Jiahe Yang, Siqi Han, Bibo Wang, Yanyan Chen, Chao Liu, Hongju Yu, Lijun Xue, Jian Geng, Yanan Chen, Tingting Dai, Lili Ren, Qian Wang, Xiaobei Liu, Xiaoyuan Chu, Cheng Chen   +21 more
doaj   +1 more source

RNA-Seq of the nucleolus reveals abundant SNORD44-derived small RNAs. [PDF]

PLoS ONE, 2014
Small non-coding RNAs represent RNA species that are not translated to proteins, but which have diverse and broad functional activities in physiological and pathophysiological states. The knowledge of these small RNAs is rapidly expanding in part through
Baoyan Bai, Srinivasan Yegnasubramanian, Sarah J Wheelan, Marikki Laiho   +3 more
doaj   +1 more source

High-sensitivity profiling of SARS-CoV-2 noncoding region–host protein interactome reveals the potential regulatory role of negative-sense viral RNA

mSystems, 2023
A deep understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–host interactions is crucial to developing effective therapeutics and addressing the threat of emerging coronaviruses.
Liuyiqi Jiang, Mu Xiao, Qing-Qing Liao, Luqian Zheng, Chunyan Li, Yuemei Liu, Bing Yang, Aiming Ren, Chao Jiang, Xin-Hua Feng   +9 more
doaj   +1 more source