Results 1 to 10 of about 14,676 (235)
New insights into trypanosomatid U5 small nuclear ribonucleoproteins [PDF]
Memorias do Instituto Oswaldo Cruz, 2011 Several protozoan parasites exist in the Trypanosomatidae family, including various agents of human diseases. Multiple lines of evidence suggest that important differences are present between the translational and mRNA processing (trans splicing) systems
Marco Túlio A da Silva +8 more
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SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights [PDF]
Annals of Clinical and Translational NeurologyObjective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far,
Nuria Muelas +18 more
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Spliceosomal snRNA Epitranscriptomics
Frontiers in Genetics, 2021 Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell ...
Pedro Morais, Hironori Adachi, Yi-Tao Yu
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Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder
Nature Communications, 2021 GEMIN5, an RNA-binding protein, is required for formation of small nuclear ribonucleoproteins. Here, the authors identify loss of function mutations in GEMIN5 that are associated with a human neurodevelopmental disorder.
Sukhleen Kour +69 more
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Non-Coding RNA, 2023 Traditionally, small molecule-based drug discovery has mainly focused on proteins as the drug target. Opening RNA as an additional target space for small molecules offers the possibility to therapeutically modulate disease-driving non-coding RNA targets ...
Nina Zablowsky +8 more
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Cajal body proteins differentially affect the processing of box C/D scaRNPs. [PDF]
PLoS ONE, 2015 Small nuclear ribonucleoproteins (snRNPs), which are required for pre-mRNA splicing, contain extensively modified snRNA. Small Cajal body-specific ribonucleoproteins (scaRNPs) mediate these modifications.
Isioma I Enwerem +3 more
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Principles and correction of 5’-splice site selection
RNA Biology, 2022 In Eukarya, immature mRNA transcripts (pre-mRNA) often contain coding sequences, or exons, interleaved by non-coding sequences, or introns. Introns are removed upon splicing, and further regulation of the retained exons leads to alternatively spliced ...
Florian Malard +2 more
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PHF5A promotes colorectal cancerprogression by alternative splicing of TEAD2
Molecular Therapy: Nucleic Acids, 2021 Dysregulated alternative splicing (AS) plays critical roles in driving cancer progression, and the underlying mechanisms remain largely unknown. Here, we demonstrated that PHF5A, a component of U2 small nuclear ribonucleoproteins, was frequently ...
Yue Chang +21 more
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RNA-Seq of the nucleolus reveals abundant SNORD44-derived small RNAs. [PDF]
PLoS ONE, 2014 Small non-coding RNAs represent RNA species that are not translated to proteins, but which have diverse and broad functional activities in physiological and pathophysiological states. The knowledge of these small RNAs is rapidly expanding in part through
Baoyan Bai +3 more
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Detection of antibodies to small nuclear ribonucleoproteins and small cytoplasmic ribonucleoproteins using unlabeled cell extracts [PDF]
Arthritis & Rheumatism, 1985 AbstractRNA molecules immunoprecipitated with sera from patients who have rheumatic diseases can be readily detected in polyacrylamide gels by using ethidium bromide and silver stains. With these stains, we found that RNA patterns characteristic of a broad range of specific small nuclear ribonucleoproteins and small cytoplasmic ribonucleoproteins were ...
M S, Forman +4 more
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