Results 11 to 20 of about 139,231 (236)
Detection of antibodies to small nuclear ribonucleoproteins and small cytoplasmic ribonucleoproteins using unlabeled cell extracts [PDF]
Arthritis & Rheumatism, 1985 AbstractRNA molecules immunoprecipitated with sera from patients who have rheumatic diseases can be readily detected in polyacrylamide gels by using ethidium bromide and silver stains. With these stains, we found that RNA patterns characteristic of a broad range of specific small nuclear ribonucleoproteins and small cytoplasmic ribonucleoproteins were ...
Tsuneyo Mimori +4 more
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Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. [PDF]
Proceedings of the National Academy of Sciences, 1992 The major nuclear ribonucleoproteins (RNPs) involved in pre-mRNA processing are classified in broad terms either as small nuclear RNPs (snRNPs), which are major participants in the splicing reaction, or heterogeneous nuclear RNPs (hnRNPs), which traditionally have been thought to function in general pre-mRNA packaging.
W J Habets +6 more
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Nuclear organization of splicing small nuclear ribonucleoproteins in adenovirus-infected cells [PDF]
Journal of Virology, 1993 We have studied the effect of adenovirus infection on the nuclear organization of splicing small nuclear ribonucleoproteins (snRNPs) in HeLa cells. In uninfected HeLa cells, snRNPs are widespread throughout the nucleoplasm but also are concentrated in specific nuclear structures, including coiled bodies, interchromatin granules, and perichromatin ...
Bridge, E. +3 more
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Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes. [PDF]
Molecular and Cellular Biology, 1987 Protection experiments with antibodies against small nuclear ribonucleoproteins (snRNPs) have elucidated the location of and requirements for interactions between snRNPs and human beta-globin transcripts during splicing in vitro. U2 snRNP association with the intron branch site continues after branch formation, requires intact U2 RNA, and is affected ...
Benoit Chabot, Joan A. Steitz
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U1 Small Nuclear Ribonucleoproteins are Required Early During Spliceosome Assembly [PDF]
Molecular and Cellular Biology, 1987 U1 small nuclear ribonucleoproteins (snRNPs) are required for in vitro splicing of pre-mRNA. Sequences within U1 RNA hybridize to, and thus recognize, 5' splice junctions. We have investigated the mechanism of association of U1 snRNPs with the spliceosome. U1-specific antibodies detected U1 association with precursor RNA early during assembly.
M Zillmann, S M Berget, S D Rose
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Nucleoplasmic organization of small nuclear ribonucleoproteins in cultured human cells. [PDF]
The Journal of cell biology, 1993 The organization of eight small nuclear ribonucleoproteins (the U1, U2, U4, U5, and U6 RNAs previously studied by others and three additional snRNAs, U11, U12, and 7SK) has been investigated in cultured human cells by fluorescence in situ hybridization with antisense DNA and 2'-O-Me RNA oligonucleotides.
A G Matera, David C. Ward
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Polypeptide components of human small nuclear ribonucleoproteins. [PDF]
Proceedings of the National Academy of Sciences, 1983 Small nuclear RNA molecules (snRNAs) are associated with polypeptides in vivo, forming small nuclear ribonucleoprotein complexes (snRNPs). These snRNP complexes are targets for certain autoimmune antisera. Antisera of the type anti-Sm precipitate (and therefore define) a class including U1, U2, U4, U5, and U6 snRNAs, whereas antisera of the anti-RNP ...
Su-Yun Chung +2 more
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Principles and correction of 5’-splice site selection
RNA Biology, 2022 In Eukarya, immature mRNA transcripts (pre-mRNA) often contain coding sequences, or exons, interleaved by non-coding sequences, or introns. Introns are removed upon splicing, and further regulation of the retained exons leads to alternatively spliced ...
Florian Malard +2 more
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RNA-Seq of the nucleolus reveals abundant SNORD44-derived small RNAs. [PDF]
PLoS ONE, 2014 Small non-coding RNAs represent RNA species that are not translated to proteins, but which have diverse and broad functional activities in physiological and pathophysiological states. The knowledge of these small RNAs is rapidly expanding in part through
Baoyan Bai +3 more
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mSystems, 2023 A deep understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–host interactions is crucial to developing effective therapeutics and addressing the threat of emerging coronaviruses.
Liuyiqi Jiang +9 more
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