Results 21 to 30 of about 139,231 (236)
Molecular Neurodegeneration, 2014 BackgroundWe recently identified U1 small nuclear ribonucleoprotein (snRNP) tangle-like aggregates and RNA splicing abnormalities in sporadic Alzheimer’s disease (AD).
Chadwick M. Hales +10 more
semanticscholar +1 more source
U1RNP/lncRNA/Transcription Cycle Axis Promotes Tumorigenesis of Hepatocellular Carcinoma
Diagnostics, 2022 As a component of the spliceosome, U1 small nuclear ribonucleoproteins (U1RNPs) play critical roles in RNA splicing, and recent studies have shown that U1RNPs could recruit long non-coding RNAs (lncRNAs) to chromatin which are involved in cancer ...
Shun Li +4 more
doaj +1 more source
Insights into the
WIREs RNA, 2014 The 164 bp U1 small nuclear (sn) RNA is one of the most abundant noncoding (nc) RNA in human cells, estimated to be in the region of 106 copies/cell. Although best known for its role in pre‐messenger RNA (mRNA) splicing events, research over the past 20 years has revealed diverse functions of this ncRNA in mammalian cell types.
Guiro, J, O'Reilly, D
openaire +4 more sources
Modifications in small nuclear RNAs and their roles in spliceosome assembly and function
Biological chemistry, 2018 Modifications in cellular RNAs have emerged as key regulators of all aspects of gene expression, including pre-mRNA splicing. During spliceosome assembly and function, the small nuclear RNAs (snRNAs) form numerous dynamic RNA-RNA and RNA-protein ...
M. Bohnsack, K. Sloan
semanticscholar +1 more source
Small nuclear ribonucleoproteins and heterogeneous nuclear ribonucleoproteins in the amphibian germinal vesicle: loops, spheres, and snurposomes. [PDF]
The Journal of cell biology, 1991 We have examined the distribution of snRNPs in the germinal vesicle (GV) of frogs and salamanders by immunofluorescent staining and in situ nucleic acid hybridization. The major snRNAs involved in pre-mRNA splicing (U1, U2, U4, U5, and U6) occur together in nearly all loops of the lampbrush chromosomes, and in hundreds to thousands of small granules (1-
H. G. Callan +3 more
openaire +3 more sources
Crystal Structures of Influenza A Virus Matrix Protein M1: Variations on a Theme [PDF]
, 2014 Matrix protein 1 (M1) of the influenza A virus plays multiple roles in virion assembly and infection. Interest in the pH dependence of M1\u27s multiple functions led us to study the effect of subtle pH changes on M1 structure, resulting in the ...
Desai, Umesh R. +5 more
core +3 more sources
Journal of Biological Chemistry, 2011 The RNA-binding protein Y14 heterodimerizes with Mago as the core of the exon junction complex during precursor mRNA splicing and plays a role in mRNA surveillance in the cytoplasm.
Tzu-Wei Chuang, Pey-Jey Peng, W. Tarn
semanticscholar +1 more source
Brazilian Journal of Medical and Biological Research, 2004 We detected anti-human small nuclear ribonucleoprotein (snRNP) autoantibodies in chagasic patients by different immunological methods using HeLa snRNPs.
M.C. Bosetto +3 more
doaj +1 more source
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP [PDF]
, 2013 Through controlling the nuclear level of active positive transcription elongation factor b (P-TEFb), the 7SK small nuclear RNA (snRNA) functions as a key regulator of RNA polymerase II transcription.
Bayfield +43 more
core +2 more sources
Arthritis & Rheumatism, 2011 OBJECTIVE Autoantibodies in the systemic rheumatic diseases are clinically useful biomarkers of the diagnosis or of certain clinical characteristics. An unusual pattern of immunoprecipitation, in which the D, E, F, and G proteins of small nuclear RNPs ...
M. Satoh +9 more
semanticscholar +1 more source