Results 31 to 40 of about 191,709 (318)

Plasma Pharmacokinetics of High-Dose Oral versus Intravenous Rifampicin in Patients with Tuberculous Meningitis: a Randomized Controlled Trial

medRxiv, 2021
Higher doses of intravenous rifampicin may improve outcomes in tuberculous meningitis but are impractical in high-burden settings. We hypothesized that plasma rifampicin exposures would be similar between oral dosing of 35 mg/kg of body weight and ...
S. Wasserman, A. Davis, C. Stek, M. Chirehwa, S. Botha, R. Daroowala, Marise Bremer, M. Maxebengula, Sonya Koekemoer, R. Goliath, A. Jackson, T. Crede, J. Naudé, P. Szymanski, Y. Vallie, M. S. Moosa, L. Wiesner, J. Black, G. Meintjes, G. Maartens, R. Wilkinson   +20 more
semanticscholar   +1 more source

Use of Xpert MTB/RIF in Decentralized Public Health Settings and Its Effect on Pulmonary TB and DR-TB Case Finding in India [PDF]

, 2015
Background Xpert MTB/RIF, the first automated molecular test for tuberculosis, is transforming the diagnostic landscape in high-burden settings. This study assessed the impact of up-front Xpert MTB/RIF testing on detection of pulmonary tuberculosis (PTB)
Alavadi, U, Arinaminpathy, N, Babre, A, Boehme, C, Denkinger, C, Dewan, PK, Ghedia, M, Gray, C, Gupta, RS, Kulsange, S, Paramasivan, CN, Parmar, M, Raizada, N, Ramachandran, R, Sachdeva, KS, Sreenivas, A, Thakur, R, Vadera, B, Van den Hof, S, Van't Hoog, AH   +19 more
core   +1 more source

Ribosomal RNA degradation induced by the bacterial RNA polymerase inhibitor rifampicin

bioRxiv, 2021
Rifampicin, a broad-spectrum antibiotic, inhibits bacterial RNA polymerase. Here we show that rifampicin treatment of Escherichia coli results in a 50% decrease in cell size due to a terminal cell division. This decrease is a consequence of inhibition of
Lina Hamouche, L. Poljak, A. J. Carpousis   +2 more
semanticscholar   +1 more source

Cell membrane components of Brucella melitensis play important roles in the resistance of low-level rifampicin.

PLoS Neglected Tropical Diseases, 2020
Brucella spp. are facultative intracellular pathogens that can persistently colonize host cells and cause the zoonosis- brucellosis. The WHO recommended a treatment for brucellosis that involves a combination of doxycycline, rifampicin, or streptomycin ...
Xiaowen Yang, Tonglei Wu, Wenxiao Liu, Guozhong Tian, Hongyan Zhao, Dongri Piao, Hai Jiang, Qingmin Wu   +7 more
doaj   +1 more source

High dose rifampicin kills persisters, shortens treatment duration and reduces relapse rate in vitro and in vivo

Frontiers in Microbiology, 2015
Although high-dose rifampicin holds promise for improving tuberculosis control by potentially shortening treatment duration, these effects attributed to eradication of persistent bacteria are unclear. The presence of persistent M.
Yanmin eHu, Alexander eLiu, Fatima eOrtega-Muro, Laura eAlameda-Martin, Denis eMitchison, Anthony eCoates   +5 more
doaj   +1 more source

Nevirapine versus Efavirenz for patients co-infected with HIV and Tuberculosis: A Randomised Non-Inferiority Trial [PDF]

, 2013
BACKGROUND: In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-
Agnès Sobry, Alexandra Calmy, Anne-Marie Taburet, Avihingsanon, Blackwelder, Boulle, Carlota Silva, Chen, Christine Rouzioux, Christophe Michon, Cohen, Cohen, Davies, Dejesus, Dieterich, Elisabeth Baudin, Elizabete Nunes, Flandre, Ford, Gengiah, Gulick, Ilesh Jani, Kwara, Laura Ciaffi, Maartens, Manosuthi, Manosuthi, Maryline Bonnet, Matteelli, Mbuagbaw, Meintjes, Nilesh Bhatt, Rui Bastos, Scourfield, Shipton, Soriano, Swaminathan, Tang, Telenti, van Leth   +39 more
core   +3 more sources

Efficacy of Treatments for Cholestatic Pruritus: A Systemic Review and Meta-analysis

Acta Dermato-Venereologica, 2022
Cholestatic itch is a disabling symptom that may be secondary to liver or biliary diseases. Management of cholestatic pruritus is complex. A systematic review and meta-analysis on the efficacy of treatments for cholestatic pruritus were performed. PubMed
Charles Dervout, Nicholas Boulais, Thomas Barnetche, Jean-Baptiste Nousbaum, Emilie Brenaut, Laurent Misery   +5 more
doaj   +1 more source

Xpert MTB/RIF and Xpert MTB/RIF Ultra for pulmonary tuberculosis and rifampicin resistance in adults

Cochrane Database of Systematic Reviews, 2019
Background Xpert MTB/RIF (Xpert MTB/RIF) and Xpert MTB/RIF Ultra (Xpert Ultra), the newest version, are the only World Health Organization (WHO)‐recommended rapid tests that simultaneously detect tuberculosis and rifampicin resistance in persons with ...
D. Horne, Mikashmi Kohli, Jerry S Zifodya, Ian Schiller, N. Dendukuri, D. Tollefson, S. Schumacher, E. Ochodo, M. Pai, K. Steingart   +9 more
semanticscholar   +1 more source

High dose oral and intravenous rifampicin for improved survival from adult tuberculous meningitis: a phase II open-label randomised controlled trial (the RifT study) [version 1; referees: 2 approved]

Wellcome Open Research, 2018
Background: Tuberculous meningitis (TBM) has 44% (95%CI 35-52%) in-hospital mortality with standard therapy in Uganda. Rifampicin, the cornerstone of TB therapy, has 70% oral bioavailability and ~10-20% cerebrospinal fluid (CSF) penetration.
Fiona V. Cresswell, Kenneth Ssebambulidde, Daniel Grint, Lindsey te Brake, Abdul Musabire, Rachel R. Atherton, Lillian Tugume, Conrad Muzoora, Robert Lukande, Mohammed Lamorde, Rob Aarnoutse, David Meya, David R. Boulware, Alison M. Elliott   +13 more
doaj   +1 more source

Determining the Prevalence of Rifampicin Resistant Tuberculosis in A Tertiary Care Centre of North India by using Rapid Culture Method and Gene Xpert

Journal of Pure and Applied Microbiology, 2021
The objective of the present study is to find the prevalence of Mycobacterium tuberculosis from respiratory samples like sputum, BAL and pleural fluid, compare conventional LJ culture with rapid culture method i.e Mycobacterium growth indicator tube ...
Bipin Chandra Pokhriyal, Dimple Raina, Iva Chandola, Nidhi Negi, Hitendra Singh, Vijay Kataria   +5 more
doaj   +1 more source