Results 91 to 100 of about 97,638 (260)

Prevalence and patterns of rifampicin and isoniazid resistance conferring mutations in Mycobacterium tuberculosis isolates from Uganda.

PLoS ONE, 2018
BackgroundAccurate diagnosis of tuberculosis, especially by using rapid molecular assays, can reduce transmission of drug resistant tuberculosis in communities.
Edgar Kigozi, George W Kasule, Kenneth Musisi, Deus Lukoye, Samuel Kyobe, Fred Ashaba Katabazi, Eddie M Wampande, Moses L Joloba, David Patrick Kateete   +8 more
doaj   +1 more source

Treatment of tuberculosis in a region with high drug resistance: Outcomes, drug resistance amplification and re-infection [PDF]

, 2011
Introduction: Emerging antituberculosis drug resistance is a serious threat for tuberculosis (TB) control, especially in Eastern European countries. Methods: We combined drug susceptibility results and molecular strain typing data with treatment outcome ...
Andrew, P W, Barer, M, Bonnet, M, Checchi, F, Fattorini, L, Jarosz, T, Meacci, F, Melzer, J, Niemann, S, Oggioni, M R, Orefici, G, Orrù, G, Pardini, M, Rinder, H, Rüsch-Gerdes, S, Varaine, F, Yesilkaya, H   +16 more
core   +2 more sources

Mutations inside rifampicin-resistance determining region of rpoB gene associated with rifampicin-resistance in Mycobacterium tuberculosis

Journal of Infection and Public Health, 2018
Rifampicin (RIF) plays a pivotal role in the treatment of tuberculosis due to its bactericidal effects. Because the action of RIF is on rpoB gene encoding RNA polymerase β subunit, 95% of RIF resistant mutations are present in rpoB gene. The majority of the mutations in rpoB gene are found within an 81bp RIF-resistance determining region (RRDR ...
Myo T. Zaw, Nor A. Emran, Zaw Lin
openaire   +3 more sources

Genetic Transformation of Rifampicin Resistance in Lactobacillus acidophilus [PDF]

Microbiology, 1986
Lactobacillus acidophilus strain 100-33, originally isolated from swine faeces, was transformed to rifampicin resistance with DNA from spontaneous rifampicin-resistant mutants derived from it. Cells of the recipient strain were treated with lysozyme and mutanolysin, mixed with donor DNA and polyethylene glycol and grown on a regeneration medium ...
J H, Lin, D C, Savage
openaire   +2 more sources

Survival of a potential bacterial biocontrol agent in the soil and its impact on microbial communities

Pest Management Science, EarlyView.
In soil microcosms, the candidate Bacillus persisted ≥6 months and caused modest community shifts whose transience and magnitude were soil dependent. Abstract BACKGROUND Sclerotinia sclerotiorum is a major crop pathogen commonly managed using fungicides.
Amélie Polrot, Jérémie Béguet, Marie‐Christine Breuil, Marion Devers‐Lamrani, Fabrice Martin‐Laurent, Nadine Rouard, Aymé Spor   +6 more
wiley   +1 more source

In vitro emergence of rifampicin resistance in Propionibacterium acnes and molecular characterization of mutations in the rpoB gene [PDF]

, 2017
Objectives Activity of rifampicin against Propionibacterium acnes biofilms was recently demonstrated, but rifampicin resistance has not yet been described in this organism. We investigated the in vitro emergence of rifampicin resistance in P.
Corvec, Stéphane, Furustrand Tafin, Ulrika, Trampuz, Andrej   +2 more
core  

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Low-cost rapid detection of rifampicin resistant tuberculosis using bacteriophage in Kampala, Uganda [PDF]

, 2007
Background Resistance to anti-tuberculosis drugs is a serious public health problem. Multi-drug resistant tuberculosis (MDR-TB), defined as resistance to at least rifampicin and isoniazid, has been reported in all regions of the world. Current phenotypic
Edward C Jones-Lopez, Francis Mumbowa, Hamidou Traore, Jerrold J Ellner, Kalpana Narayan, Kathleen D Eisenach, Kim Mallard, Moses L Joloba, Peter G Smith, Roy D Mugerwa, Ruth McNerney, Sam Ogwang, Susan Kayes   +12 more
core   +2 more sources

Overexpression of Escherichia coli yaiX Confers Multidrug Resistance and Enhances Virulence in the Silkworm Infection Model

Microbiology and Immunology, EarlyView.
ABSTRACT The emergence of bacteria with both antimicrobial resistance and high virulence has become a global health concern, underscoring the urgent need to elucidate the molecular basis underlying these traits. Here, we employed the silkworm (Bombyx mori) infection model, which is suitable for high‐throughput screening, together with an Escherichia ...
Kinuka Hongu, Kazuya Ishikawa, Tomoki Kosaki, Shin‐Ichi Miyoshi, Kazuyuki Furuta, Chikara Kaito   +5 more
wiley   +1 more source

Detection of Mycobacterium tuberculosis Rifampicin Resistance Conferred by Borderline rpoB Mutations: Xpert MTB/RIF is Superior to Phenotypic Drug Susceptibility Testing

Infection and Drug Resistance, 2022
Hui Xia,1 Yuanyuan Song,1 Yang Zheng,1 Shengfen Wang,1 Bing Zhao,1 Wencong He,1 Dongxin Liu,2 Xichao Ou,1 Yang Zhou,1 Yanlin Zhao1 1National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing ...
Xia H, Song Y, Zheng Y, Wang S, Zhao B, He W, Liu D, Ou X, Zhou Y, Zhao Y   +9 more
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