Results 11 to 20 of about 97,638 (260)

Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial. [PDF]

Lancet, The, 2020
BACKGROUND: Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulcerans infection that damages the skin and subcutis. It is most prevalent in western and central Africa and Australia.
Abass, KM, Agossadou, D, Ampadu, EO, Asiedu, KB, Chauty, A, Egondi, TW, Frimpong, M, Ganlonon, L, Gateau, T, Grosset, J, Lehman, L, Macdonald, JM, Marion, E, Ochieng Otieno, M, Ohene, S-A, Omollo, R, Paintsil, A, Phillips, RO, Robert, J, Saizonou, R, Sarfo, FS, Sarpong, G, Sarpong, NF, Saunderson, P, Stienstra, Y, study team, Thompson, W, Tiendrebeogo, A, Treadwell, T, van der Werf, TS, Wansbrough-Jones, M, Wilson, T   +31 more
core   +5 more sources

Rifampicin Resistance by Xpert MTB/RIF Assay in Pulmonary Tuberculosis- Is there a Need for Confirmation by Retesting? [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Xpert Mycobacterium tuberculosis/Resistance to Rifampicin (MTB/RIF) assay detects MTB Complex (MTBC) and rifampicin resistance simultaneously. In high prevalence countries like India, detection of rifampicin resistance in sputum specimen of
Swapna Rajesh Kanade, Swati Vijay, Gita Nataraj   +2 more
doaj   +1 more source

Prevalence of rifampicin resistant pulmonary tuberculosis using geneXpert assay in Ethiopia, a systematic review and meta-analysis

Heliyon, 2023
Background: Drug-resistant tuberculosis continues to be a global public health threat. Ethiopia is one of the high-burden countries for tuberculosis and multi-drug resistant tuberculosis.
Maritu Demelash, Endalkachew Nibret, Tamirat Hailegebriel, Zebasil Minichil, Daniel Mekonnen   +4 more
doaj   +1 more source

Relationship between rifampicin resistance and RpoB substitutions of Rhodococcus equi strains isolated in France

Journal of Global Antimicrobial Resistance, 2020
Objectives: Study of the rifampicin resistance of Rhodococcus equi strains isolated from French horses over a 20-year period. Methods: Rifampicin susceptibility was tested by disk diffusion (DD) and broth macrodilution methods, and rpoB gene sequencing ...
Sandrine Petry, Corinne Sévin, Sofia Kozak, Nathalie Foucher, Claire Laugier, Maud Linster, Marie-France Breuil, Marie-Capucine Dupuis, Aymeric Hans, Fabien Duquesne, Jackie Tapprest   +10 more
doaj   +1 more source

GeneXpert MTB/RIF Ultra performance to detect uncommon rpoB mutations in Mycobacterium tuberculosis

BMC Research Notes, 2023
Objective To investigate the performance of GeneXpert MTB/RIF Ultra to accurately detect rifampicin resistance for less common rpoB mutations that potentially confer phenotypic resistance, we tested 28 such Mycobacterium tuberculosis cultures with Xpert ...
Leen Rigouts, Jelle Keysers, Reenaers Rabab, Kristina Fissette, Armand van Deun, Bouke Catherine de Jong   +5 more
doaj   +1 more source

Could high-concentration rifampicin kill rifampicin-resistant M. tuberculosis? Rifampicin MIC test in rifampicin-resistant isolates from patients with osteoarticular tuberculosis [PDF]

Journal of Orthopaedic Surgery and Research, 2014
Several studies have shown that the intralesional concentration of rifampicin in osteoarticular tuberculosis is typically at a subtherapeutic level. Sustained or controlled release by novel drug delivery systems has been investigated to maintain an effective rifampicin concentration, but the local administration of rifampicin remains controversial ...
Zhang, Zehua, Dai, Fei, Luo, Fei, Zhong, Min, Huang, Zhenggu, Hou, Tianyong, Xu, Jianzhong   +6 more
openaire   +2 more sources

Prevalence and drivers of false-positive rifampicin-resistant Xpert MTB/RIF results: a prospective observational study in Rwanda

The Lancet Microbe, 2020
Summary: Background: The Xpert MTB/RIF (Xpert) assay is used globally to rapidly diagnose tuberculosis and resistance to rifampicin. We investigated the frequency and predictors of false-positive findings of rifampicin resistance with Xpert. Methods: We
Jean Claude Semuto Ngabonziza, MSc, Tom Decroo, PhD, Patrick Migambi, MSc, Yves Mucyo Habimana, MD, Armand Van Deun, PhD, Conor J Meehan, PhD, Gabriela Torrea, PhD, Faridath Massou, PharmD, Willem Bram de Rijk, BS, Bertin Ushizimpumu, BS, Esdras Belamo Niyigena, BS, Emil Ivan, PhD, Jules Mugabo Semahore, MD, Jean Baptiste Mazarati, PhD, Corinne Simone Merle, PhD, Philip Supply, PhD, Dissou Affolabi, ProfPhD, Leen Rigouts, PhD, Bouke Catherine de Jong, ProfPhD   +18 more
doaj   +1 more source

Airway microecology in rifampicin-resistant and rifampicin-sensitive pulmonary tuberculosis patients

BMC Microbiology, 2022
Abstract Background Pulmonary tuberculosis is a chronic infectious disease of the respiratory system. It is still one of the leading causes of death from a single infectious disease, but it has been stuck in the study of a single pathogen. Recent studies have shown that many diseases are associated with disruption of the
Xingshan Cai, Yang Luo, Yuanliang Zhang, Yuan Lin, Bitong Wu, Zhizhong Cao, Zuqiong Hu, Xingyi Wu, Shouyong Tan   +8 more
openaire   +3 more sources

Cell membrane components of Brucella melitensis play important roles in the resistance of low-level rifampicin.

PLoS Neglected Tropical Diseases, 2020
Brucella spp. are facultative intracellular pathogens that can persistently colonize host cells and cause the zoonosis- brucellosis. The WHO recommended a treatment for brucellosis that involves a combination of doxycycline, rifampicin, or streptomycin ...
Xiaowen Yang, Tonglei Wu, Wenxiao Liu, Guozhong Tian, Hongyan Zhao, Dongri Piao, Hai Jiang, Qingmin Wu   +7 more
doaj   +1 more source

Mutations outside the rifampicin resistance-determining region associated with rifampicin resistance in Mycobacterium tuberculosis [PDF]

Journal of Antimicrobial Chemotherapy, 2011
Ninety-six percent of rifampicin resistance in Mycobacterium tuberculosis was shown to be associated with mutations inside the 81 bp rifampicin resistance-determining region (RRDR) located in the centre of the rpoB gene. The detection of rifampicin resistance by targeting the RRDR failed to match with a resistant phenotype in 4% of all cases. Our study
Lau, TCK, Siu, GKH, Zhang, Y, Lau, RWT, Ho, PL, Yew, WW, Tsui, SKW, Cheng, VCC, Yuen, KY, Yam, WC   +9 more
openaire   +4 more sources