Results 181 to 190 of about 17,697 (207)

Targeting PANoptosis in Bacterial-Induced Inflammatory Diseases: Mechanisms and Therapeutic Interventions. [PDF]

J Inflamm Res
Wang T, Lu Y, Zhang X, Yu F.
europepmc   +1 more source

The TNFR-RIPK1/RIPK3 signalling pathway mediates the effect of lanthanum on necroptosis of nerve cells. [PDF]

Open Life Sci
Jin B, Ding Z, Sun Y, Gao S, Sui X, Ding M, Qu X, Zheng L.   +7 more
europepmc   +1 more source

O-GlcNAcylation in novel regulated cell death: ferroptosis, pyroptosis, and necroptosis. [PDF]

Cell Death Discov
Wang YZ, Zhao HY, Nyima T, Ma Z.
europepmc   +1 more source

RIPK1 Drives JAK1-STAT3 Signaling to Promote CXCL1-Mediated Neutrophil Recruitment in Sepsis-Induced Lung Injury. [PDF]

Adv Sci (Weinh)
Sun H, Li X, Gao S, Jiang Y, Wu X, Chen Z, Wu H, Hua Q, Zu R, Xiang H, Ben-Ami R, Miao C, Tan L, Li Y, Wang J, Chen W.   +15 more
europepmc   +1 more source

TAK1 activates PANoptosis through the NF-κB signalling pathway to delay diabetic wound healing. [PDF]

Burns Trauma
Wang X, Zhou S, Zhang Y, Zhang X, Wu S, Huang Y, Xie J, Xiong K, Yang R.   +8 more
europepmc   +1 more source

Design, Optimization, and Development of RIPK1 Degraders with Improved Pharmacokinetic and Pharmacodynamic Properties. [PDF]

J Med Chem
Lu D, Yu X, Lin H, Cheng R, Yang B, Zhang M, Chen J, Li F, Qi X, Wang J.   +9 more
europepmc   +1 more source

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Genetic Regulation of RIPK1 and Necroptosis

Annual Review of Genetics, 2021
The receptor-interacting protein kinase 1 (RIPK1) is recognized as a master upstream regulator that controls cell survival and inflammatory signaling as well as multiple cell death pathways, including apoptosis and necroptosis. The activation of RIPK1 kinase is extensively modulated by ubiquitination and phosphorylation, which are mediated by multiple
Daichao, Xu, Chengyu, Zou, Junying, Yuan
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RIPK1 and RIPK3 in antibacterial defence

Biochemical Society Transactions, 2022
Upon sensing pathogenic bacterial infection, host cells activate a multitude of inflammatory and immunogenic responses to promote bacterial clearance and restore tissue homeostasis. RIPK1 and RIPK3 are two key players in antimicrobial defence, by either driving inflammatory signalling or inducing programmed cell death activation, ranging from apoptosis,
Hui Wen Yeap, Kaiwen W. Chen
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RIPK1 ubiquitination: Evidence, correlations and the undefined

Seminars in Cell & Developmental Biology, 2021
Over the last two decades the mechanisms that underpin cell survival and cell death have been intensively studied. One molecule in particular, Receptor Interacting Protein Kinase 1 (RIPK1), has gained interest due to the ability to function upstream of both NF-κB signaling and caspase-dependent and -independent cell death.
Daniel S, Simpson, Anna, Gabrielyan, Rebecca, Feltham   +2 more
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