Results 51 to 60 of about 18,020 (210)

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1 [PDF]

Cell, 2018
Partial loss of TANK-binding kinase 1 (TBK1) causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Xu et al. identify the role of TBK1 in suppressing neuroinflammation and apoptosis by its inhibition of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and elucidate how aging and genetic susceptibility together ...
Haiyang, Yu, Don W, Cleveland
openaire   +2 more sources

Preventing necroptosis by scavenging ROS production alleviates heat stress-induced intestinal injury

International Journal of Hyperthermia, 2020
Background Worldwide heat stroke incidence has increased in recent years and is associated with high morbidity and mortality. Therefore, it is critical to identify mechanisms that mediate heat stroke.
Li Li, Hongping Tan, Zhimin Zou, Jian Gong, Junjie Zhou, Na Peng, Lei Su, Marc Maegele, Daozhang Cai, Zhengtao Gu   +9 more
doaj   +1 more source

Ubiquitin-mediated regulation of RIPK1 kinase activity independent of IKK and MK2 [PDF]

, 2018
Tumor necrosis factor (TNF) can drive inflammation, cell survival, and death. While ubiquitylation-, phosphorylation-, and nuclear factor kappa B (NF-kappa B)-dependent checkpoints suppress the cytotoxic potential of TNF, it remains unclear whether ...
Annibaldi, Alessandro, Bertin, John, Bianchi, Katiuscia, Choi, Sze Men, Elliott, Paul R, John, Sidonie Wicky, Komander, David, Liccardi, Gianmaria, Meier, Pascal, Ruan, Jianbin, Silke, John, Swatek, Kirby N, Van Coillie, Samya, Vanden Berghe, Tom, Vandenabeele, Peter, Wu, Hao   +15 more
core   +2 more sources

Necroptosis in bacterial infections

Frontiers in Immunology
Necroptosis, a recently discovered form of cell-programmed death that is distinct from apoptosis, has been confirmed to play a significant role in the pathogenesis of bacterial infections in various animal models. Necroptosis is advantageous to the host,
Xing Yu, Jin Yuan, Linxi Shi, Shuying Dai, Lei Yue, Min Yan   +5 more
doaj   +1 more source

Clinical phenotype of a Chinese patient with RIPK1 deficiency due to novel mutation

Genes and Diseases, 2020
Accumulating evidence indicates that RIPK1 is associated with inflammation and apoptotic. RIPK1 deficiency leads to proinflammatory signaling impaired. However, only few patients with homozygous loss-of-function mutation in RIPK1 gene had been reported ...
Li Lin, Ying Wang, Luyao Liu, Wenjing Ying, Wenjie Wang, Bijun Sun, Jinqiao Sun, Xiaochuan Wang   +7 more
doaj   +1 more source

Primidone blocks RIPK1-driven cell death and inflammation [PDF]

Cell Death & Differentiation, 2020
AbstractThe receptor-interacting serine/threonine protein kinase 1 (RIPK1) is a key mediator of regulated cell death and inflammation. Recent studies suggest that RIPK1 inhibition would fundamentally improve the therapy of RIPK1-dependent organ damage in stroke, myocardial infarction, kidney failure, and systemic inflammatory response syndrome ...
Riebeling, Theresa, Jamal, Kunzah, Wilson, Rebecca, Kolbrink, Benedikt, von Samson-Himmelstjerna, Friedrich Alexander, Moerke, Caroline, Ramos Garcia, Laura, Dahlke, Eileen, Michels, Friederike, Lühder, Fred, Schunk, Domagoj, Doldi, Philipp, Tyczynski, Bartosz, Kribben, Andreas, Flüh, Charlotte, Theilig, Franziska, Kunzendorf, Ulrich, Meier, Pascal, Krautwald, Stefan   +18 more
openaire   +5 more sources

TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages

Frontiers in Cell and Developmental Biology, 2019
Macrophages stand in the first line of defense against a variety of pathogens but are also involved in the maintenance of tissue homeostasis. To fulfill their functions macrophages sense a broad range of pathogen- and damage-associated molecular patterns
Harald Wajant, Daniela Siegmund
doaj   +1 more source

RIPK1 Coordinates Bone Marrow Mesenchymal Stem Cell Survival by Maintaining Mitochondrial Homeostasis via p53

Stem Cells International, 2021
Survival of mesenchymal stem cells in the bone marrow is essential for bone marrow microenvironment homeostasis, but the molecular mechanisms remain poorly understood.
Qing Tian, Chen Cao, Weijian Qiu, Han Wu, Lijun Zhou, Zhipeng Dai, Zhenwei Li, Songfeng Chen   +7 more
doaj   +1 more source

Receptor-interacting protein kinase 1 (RIPK1) regulates cervical cancer cells via NF-κB–TNF-α pathway: An in vitro study

Translational Oncology, 2023
Introduction: Cervical cancer (CC) is associated with high morbidity and mortality rates in women. Members of the receptor-interacting protein kinase (RIPK) family are important regulators of inflammation and cell death.
Wenqi Bai, Fengjie Cui, Zihan Wang, Xianhua Gu, Xiaojing Fang, Li Zhou, Suyang Guo   +6 more
doaj   +1 more source

Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis [PDF]

, 2017
Necroptosis is a regulated form of cell death involved in several disease models including in particular liver diseases. Receptor-interacting protein kinases, RIPK1 and RIPK3, are the main serine/threonine kinases driving this cell death pathway.
Afonso, Bali, Berger, Biton, Christofferson, Conrad, Dara, Degterev, Degterev, Degterev, Dondelinger, Dondelinger, Duprez, Fabian, Fauster, Filliol, Gautheron, Günther, Harris, Harris, Harris, Hildebrand, Jouan-Lanhouet, Kopalli, Li, Li, Malhi, Miao, Murphy, Najjar, Oberst, Ramachandran, Ren, Roychowdhury, Saeed, Selig, Sun, Takahashi, Takemoto, Teng, Tiegs, Vanden Berghe, Vercammen, Wang, Wang, Xie, Zhao, Zhou   +47 more
core   +5 more sources