Results 81 to 90 of about 18,020 (210)

The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles [PDF]

, 2016
Caspases provide vital links in non-apoptotic regulatory networks controlling inflammation, compensatory proliferation, morphology and cell migration.
Aram, L, Arama, E, Bergmann, A, Bianchi, K, Domingues, CM, Feltham, R, Gstaiger, M, Liccardi, G, Meier, P, Moderau, N, Morris, O, Orme, MH, Ribeiro, PS, Robertson, D, Tare, M, Tenev, T, Wepf, A, Wicky-John, S, Williams, D, Wilson, R   +19 more
core   +5 more sources

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

FDA-approved phensuximide inhibits RIPK1-dependent immunogenic cell death

Cell Death and Disease
Receptor-interacting serine/threonine kinase 1 (RIPK1) is a pivotal protein controlling cell death and inflammation. RIPK1 is an attractive therapeutic target, given that the inhibition of RIPK1 kinase activity has been shown to be effective in animal ...
Byeong-Ju Kim, Sun Mi Hong, Hyun-Jin Noh, Jihye Kim, Su-Yeon Seon, Jeong-Eun Lee, Da-Hye Jeong, Ju-Mi Park, Sejeong Park, Sanghoon Lee, Jaewoo Kang, Dakeun Lee, Michael J. Morgan, You-Sun Kim   +13 more
doaj   +1 more source

Necrostatin-1 Analogues: Critical Issues on the Specificity, Activity and In Vivo Use in Experimental Disease Models [PDF]

, 2012
Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation.
Callewaert, N, Cauwels, A, Declercq, W, Degterev, A, DuHadaway, J B, Duprez, L, Goossens, V, Grootjans, S, Libert, C, Nerinckx, W, Prendergast, G C, Roelandt, R, Takahashi, N, Van Hauwermeiren, F, Vandenabeele, P, Yuan, Junying   +15 more
core   +2 more sources

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis

Signal Transduction and Targeted Therapy, 2023
Amyotrophic lateral sclerosis (ALS) is a devastating fatal neurodegenerative disease with no cure. Receptor-interacting protein kinase 1 (RIPK1) has been proposed to mediate pathogenesis of ALS.
Jun Wei, Min Li, Zhi Ye, Xinqian Hu, Xiaoyan He, Jia Wang, Gaofeng Chen, Chengyu Zou, Daichao Xu, Hongbing Zhang, Junying Yuan, Yunhong Zha   +11 more
doaj   +1 more source

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases [PDF]

Nature Reviews Neuroscience, 2018
Apoptosis is crucial for the normal development of the nervous system, whereas neurons in the adult CNS are relatively resistant to this form of cell death. However, under pathological conditions, upregulation of death receptor family ligands, such as tumour necrosis factor (TNF), can sensitize cells in the CNS to apoptosis and a form of regulated ...
Junying, Yuan, Palak, Amin, Dimitry, Ofengeim   +2 more
openaire   +2 more sources

6‐Shogaol Attenuates Doxorubicin‐Induced Cardiac and Skeletal Muscle Atrophy by Inhibiting E3 Ubiquitin Ligases and Necroptosis

Phytotherapy Research, EarlyView.
Doxorubicin induces cardiac and skeletal muscle atrophy by upregulating E3 ubiquitin ligases, inhibiting myogenic regulatory factors, and activating necroptosis. Cardiac atrophy can further exacerbate cardiotoxicity. 6‐Shogaol negatively regulates these processes and attenuates doxorubicin‐induced cardiac and skeletal muscle atrophy.
Xipeng Sun, Yaxian Wang, Quanjun Yang, Bo Xin, Jinlu Huang, Cheng Guo   +5 more
wiley   +1 more source

Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners

Nature Communications, 2020
RIPK1 is a critical kinase which mediates necroptosis, apoptosis and inflammation. Regulation of RIPK1 by ubiquitination is being intensively investigated.
Xingyan Li, Mengmeng Zhang, Xinyue Huang, Wei Liang, Ganquan Li, Xiaojuan Lu, Yanxia Li, Heling Pan, Linyu Shi, Hong Zhu, Lihui Qian, Bing Shan, Junying Yuan   +12 more
doaj   +1 more source

RIPK1 and RIPK3 - emerging targets in cancer?

Molecular and Cellular Therapies, 2018
RIPK1 and RIPK3 are homologous Ser/Thr kinases, which act in concert within the necrosome complexes to initiate a sub-type of regulated necrosis, termed necroptosis. Necroptosis has gradually emerged as a highly clinically relevant form of necrosis, which can be targeted therapeutically.
Kerem Gurol, Suraj Shah, Alexei Degterev
openaire   +2 more sources