Results 141 to 150 of about 19,353 (245)

NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II [PDF]

, 2016
Incontinentia Pigmenti (IP) is a rare X-linked disease characterized by early male lethality and multiple abnormalities in heterozygous females. IP is caused by NF-κB essential modulator (NEMO) mutations.
Draber, P, Esposito, E, Pescatore, A, Ursini, MV, Walczak, H   +4 more
core   +1 more source

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, Volume 13, Issue 18, 27 March 2026.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis

Disease Models & Mechanisms, 2020
Receptor-interacting protein kinase 3 (RIPK3) was recently implicated in promoting atherosclerosis progression through a proposed role in macrophage necroptosis.
Sarah Colijn, Vijay Muthukumar, Jun Xie, Siqi Gao, Courtney T. Griffin   +4 more
doaj   +1 more source

Selenomethionine alleviates kidney necroptosis and inflammation by restoring lipopolysaccharide-mediated mitochondrial dynamics imbalance via the TLR4/RIPK3/DRP1 signaling pathway in laying hens

Poultry Science
Selenomethionine (SeMet) is a beneficial organic source of selenium that is extensively used as a food additive owing to its antioxidant and anti-inflammatory properties. Due to the sensitivity of the kidneys to noxious stimuli, they are more susceptible
Xinzhang Chen, Yixuan Wang, Muyue Zhang, Yongzhen Du, Yujiao He, Shu Li   +5 more
semanticscholar   +1 more source

ALKBH3 suppresses ischemia/reperfusion‐induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
ALKBH3 alleviates myocardial ischemia/reperfusion injury by suppressing PANoptosis. ALKBH3 promotes ZBED6 translation via mRNA m1A demethylation. ZBED6 promotes the interaction between STAT1 and NEDD4L to facilitate STAT1 ubiquitination and subsequent degradation.
Hongtao Diao, Chunlei Wang, Yuting Xiong, Qiaoyue Zhao, Xinyue Zhang, Xiaohui Qi, Yuan Zou, Jiaxuan Li, Linghua Zeng, Wei Si, Feng Zhang, Ping Pang, Ning Wang, Yu Bian, Baofeng Yang   +14 more
wiley   +1 more source

TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor

Frontiers in Cell and Developmental Biology, 2020
As a programmed necrotic cell death, necroptosis has the intrinsic initiators, including receptor-interacting serine/threonine-protein kinase 1 (RIPK1), RIPK3 and mixed-lineage kinase domain-like protein (MLKL), which combine to form necroptotic ...
Lili Wang, Xixi Chang, Jinli Feng, Jiyun Yu, Jiyun Yu, Guozhu Chen   +5 more
doaj   +1 more source

Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling [PDF]

, 2016
The kinase RIPK1 is an essential signaling node in various innate immune signaling pathways being most extensively studied in the TNFR1 signaling pathway.
Darding, M, Peltzer, N, Walczak, H
core  

Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in mice

Life Science Alliance
This study shows how necroptotic effector MLKL can induce obesity and perturb lipid metabolism to drive MAFLD progression, independent of RIPK3 that regulates inflammatory events.
H. Tye, Stephanie A Conos, Tirta M. Djajawi, Timothy A. Gottschalk, Nasteho Abdoulkader, Isabella Y. Kong, H. Kammoun, V. Narayana, Tobias Kratina, Mary Speir, J. Emery, Daniel S. Simpson, Cathrine M. Hall, Angelina J. Vince, Sophia Russo, Rhiannan Crawley, Maryam Rashidi, Joanne M. Hildebrand, James M. Murphy, L. Whitehead, David P. de Souza, S. Masters, A. Samson, N. Lalaoui, Edwin D. Hawkins, Andrew J Murphy, J. Vince, Kate E. Lawlor   +27 more
semanticscholar   +1 more source

Nemo‐like kinase orchestrates the PAMP and circumstance of macrophage death in sepsis

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Julia E. Steinbeck, Adil Rasheed
wiley   +1 more source

Overexpression and oncogenic role of RIPK3 in acute myeloid leukemia associated with specific subtypes and treatment outcome

BMC Cancer
Background Receptor-interacting protein kinase 3 (RIPK3) has been implicated in the pathogenesis of diverse human cancers. However, the role of RIPK3 in acute myeloid leukemia (AML) is not fully understood, which needs further research and clarification.
Yun Wang, Ting-Juan Zhang, Liu-Chao Zhang, Zi-Jun Xu, Ming-Qiang Chu, Yang-Jing Zhao, Jiang Lin, Jun Qian, Jing-Dong Zhou   +8 more
doaj   +1 more source