Results 161 to 170 of about 19,353 (245)

Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis

Cell Reports, 2013
Caspase-8 or cellular FLICE-like inhibitor protein (cFLIP) deficiency leads to embryonic lethality in mice due to defects in endothelial tissues. Caspase-8−/− and receptor-interacting protein kinase-3 (RIPK3)−/−, but not cFLIP−/− and RIPK3−/−, double ...
Ricardo Weinlich, Andrew Oberst, Christopher P. Dillon, Laura J. Janke, Sandra Milasta, John R. Lukens, Diego A. Rodriguez, Prajwal Gurung, Chandra Savage, Thirumala D. Kanneganti, Douglas R. Green   +10 more
doaj   +1 more source

SPOP-mediated RIPK3 destabilization desensitizes LPS/sMAC/zVAD-induced necroptotic cell death

Cellular and Molecular Life Sciences
RIPK1/RIPK3-MLKL signaling molecules are fundamental in initiating necroptotic cell death, but their roles in the development of colon cancer are unclear.
Ga-Eun Lee, Geul Bang, Ji-Young Byun, Weidong Chen, Dohyun Jeung, Hana Cho, Joo Young Lee, Han Chang Kang, Hye Suk Lee, Jin Young Kim, K. Kim, Juan Wu, Soo-Bin Nam, Young Jik Kwon, Cheol-Jung Lee, Yong-Yeon Cho   +15 more
semanticscholar   +1 more source

A Novel Multi-organ Male Model of Alcohol-induced Acute-on-chronic Liver Failure Reveals NET-mediated Hepatocellular Death, Which is Prevented by RIPK3 Inhibition

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Alcohol abuse is the most frequent precipitating factor of acute-on-chronic liver failure (ACLF). We aimed at developing an alcohol-induced ACLF model and dissecting its underlying molecular mechanisms.
M. Ortega-Ribera, Zhuang Yuan, Mrigya Babuta, Veronika Brezani, Radhika Joshi, Zsuzsanna Zsengeller, P. T. Nagesh, Yanbo Wang, Roderick Bronson, Gyongyi Szabo   +9 more
semanticscholar   +1 more source

Nucleic acid sensors and programmed cell death [PDF]

, 2020
Liverpool, Layal, Maelfait, Jonathan, Rehwinkel, Jan   +2 more
core   +2 more sources

Influence of transplantation of neural stem cells on the expression of genes involved in the programmed cell death following ischemic brain stroke [PDF]

, 2019
Ishemijski moždani udar, te posljedične tkivna hipoksija i ishemija, uzrokuju značajno oštećenje moždanog tkiva. Jedan od pristupa u potrazi za pronalaskom uspješne obnove oštećenog tkiva uključuje primjenu matičnih stanica.
Hribljan, Valentina
core   +1 more source

RIPK3 Gene [PDF]

, 2020
openaire   +1 more source

RIPK3 Contributes to Thyroid Hormone-Induced Photoreceptor Degeneration

International Journal of Molecular Sciences
Thyroid hormone (TH) regulates cell proliferation, differentiation, and metabolism. Increased TH levels in circulation are associated with a higher incidence of age-related macular degeneration. In mice, TH treatment causes photoreceptor degeneration, which is accompanied by an increase in receptor-interacting serine/threonine-protein kinase 3 (RIPK3 ...
York, Lilliana R., Ma, Hongwei, Le, Yun, Griffin, Courtney T., Ding, Xi-Qin   +4 more
openaire   +1 more source

Mitochondrial permeabilization engages NF-kappa B-dependent anti-tumour activity under caspase deficiency [PDF]

, 2017
Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilization (MOMP) typically kills cells even in the absence of caspase activity.
Albert, ML, Blyth, K, Bock, F, Cao, K, Cloix, C, Dhayade, S, Fort, L, Giampazolias, E, Ichim, G, Lecis, D, Lopez, J, Machesky, L, Milling, S, Oberst, A, Orozco, S, Peltzer, N, Proics, E, Ricci, J-E, Roca, A, Rubio-Patino, C, Ryan, KM, Tait, SWG, Taraborrelli, L, Walczak, H, Woodham, E, Yatim, N, Zunino, B   +26 more
core  

RIPK3 wt Allele [PDF]

, 2020
openaire   +1 more source

Elevated RIPK3 correlates with disease burden in myelofibrosis

Blood Advances, 2023
Veronika Dill, Celina V. Wagner, Eva C. Keller, Francisco Jose Fernandez-Hernandez, Khalid Shoumariyeh, Timo O. Odinius, Lars Buschhorn, Richard T. Hauch, Christian Suren, Judith S. Hecker, Peter Herhaus, Michael Sandherr, Burkhard Schmidt, Julia Slotta-Huspenina, Florian Bassermann, Ulrike Höckendorf, Stefanie Jilg, Caterina Branca, Sebastian Vosberg, Philipp J. Jost   +19 more
openaire   +3 more sources