Results 71 to 80 of about 17,129 (242)

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

RIPK1 and RIPK3 - emerging targets in cancer?

Molecular and Cellular Therapies, 2018
RIPK1 and RIPK3 are homologous Ser/Thr kinases, which act in concert within the necrosome complexes to initiate a sub-type of regulated necrosis, termed necroptosis. Necroptosis has gradually emerged as a highly clinically relevant form of necrosis, which can be targeted therapeutically.
Kerem Gurol, Suraj Shah, Alexei Degterev
openaire   +2 more sources

Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study

Critical Care, 2019
Background Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of acute respiratory distress syndrome (ARDS).
Michael G. S. Shashaty, John P. Reilly, Hilary E. Faust, Caitlin M. Forker, Caroline A. G. Ittner, Peggy X. Zhang, Meghan J. Hotz, David Fitzgerald, Wei Yang, Brian J. Anderson, Daniel N. Holena, Paul N. Lanken, Jason D. Christie, Nuala J. Meyer, Nilam S. Mangalmurti   +14 more
doaj   +1 more source

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon [PDF]

, 2015
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia.
Clara Belzer, Giovannucci, Guido J. Hooiveld, Jan Dekker, Lapré, McGarr, Michael Müller, Michiel Kleerebezem, Noortje Ijssennagger, Roelof van der Meer, Saskia W. C. van Mil, Sesink, Sheffner, van Klinken   +13 more
core   +2 more sources

RIPK3—a predictive marker for personalized immunotherapy? [PDF]

OncoImmunology, 2016
Cancer immunotherapy is an attractive therapeutic option but it is currently unclear which patient may benefit from such approaches. Using the model of cervical cancer, we have demonstrated that PolyIC-driven immunogenicity strictly depends on the necroptosis regulator RIPK3 in the neoplastic cells.
openaire   +3 more sources

Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression [PDF]

Frontiers in Microbiology, 2018
Leishmania braziliensis infection causes skin ulcers, typically found in localized cutaneous leishmaniasis (LCL). This tissue pathology associates with different modalities of cell necrosis, which are subverted by the parasite as a survival strategy.
Nivea F. Luz, Ricardo Khouri, Ricardo Khouri, Johan Van Weyenbergh, Johan Van Weyenbergh, Dalila L. Zanette, Dalila L. Zanette, Paloma P. Fiuza, Almerio Noronha, Aldina Barral, Aldina Barral, Viviane S. Boaventura, Viviane S. Boaventura, Deboraci B. Prates, Deboraci B. Prates, Francis Ka-Ming Chan, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Valeria M. Borges, Valeria M. Borges   +20 more
openaire   +4 more sources

Investigating the role of receptor interacting protein kinase 3 in venous thrombosis

JVS - Vascular Science, 2022
Objective: Venous thromboembolism is a disease that encompasses both deep vein thrombosis and pulmonary embolism. Recent investigations have shown that receptor interacting protein kinase 3 (RIPK3), a protein known for its role in the programmed form of ...
Elise DeRoo, MD, Mitri Khoury, MD, Ting Zhou, PhD, Huan Yang, PhD, Amelia Stranz, BS, MS, Catherine Luke, LVT, LAT, Peter Henke, MD, Bo Liu, PhD   +7 more
doaj   +1 more source

Akt and mTOR mediate programmed necrosis in neurons [PDF]

, 2014
Necroptosis is a newly described form of regulated necrosis that contributes to neuronal death in experimental models of stroke and brain trauma. Although much work has been done elucidating initiating mechanisms, signaling events governing necroptosis ...
Degterev, A, Golinski, J, Jung, J E, Liang, M, Liu, Q, Lo, E H, Qiu, J, van Leyen, K, Whalen, M J, You, Z   +9 more
core   +1 more source

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Necroptosis in bacterial infections

Frontiers in Immunology
Necroptosis, a recently discovered form of cell-programmed death that is distinct from apoptosis, has been confirmed to play a significant role in the pathogenesis of bacterial infections in various animal models. Necroptosis is advantageous to the host,
Xing Yu, Jin Yuan, Linxi Shi, Shuying Dai, Lei Yue, Min Yan   +5 more
doaj   +1 more source