Results 71 to 80 of about 19,353 (245)

A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma

Cell Discovery, 2023
Mixed lineage kinase domain-like (MLKL) is widely accepted as an executioner of necroptosis, in which MLKL mediates necroptotic signaling and triggers cell death in a receptor-interacting protein kinase 3 (RIPK3)-dependent manner.
Xi-fei Jiang, Wen-Zan Deng, Siyao Tao, Zheng Tang, Yuehong Chen, Meng-Xin Tian, Ting Wang, C. Tao, Yize Li, Yuan Fang, Congying Pu, Jun Gao, Xiaoming Wang, Wei-Feng Qu, X. Gai, Zhen-Bing Ding, Yixian Fu, Ying-juan Zheng, Siyuwei Cao, Jian Zhou, Min Huang, Weiren Liu, Jun Xu, Jia Fan, Yinghong Shi   +24 more
semanticscholar   +1 more source

Ca2+/Calmodulin-Dependent Protein Kinase II Regulation by RIPK3 Alleviates Necroptosis in Transverse Arch Constriction-Induced Heart Failure

Frontiers in Cardiovascular Medicine, 2022
Some studies have reported that the activation of Ca2+/calmodulin dependent protein kinase (CaMKII) plays a vital role in the pathogenesis of cardiovascular disease.
Ji Cao, Jingjing Zhang, Jingjing Zhang, Jianan Qian, Xue Wang, Wei Zhang, Wei Zhang, Xiangfan Chen   +7 more
doaj   +1 more source

OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis

Nature Cell Biology, 2023
RIPK3–ZBP1–MLKL-mediated necroptosis is a proinflammatory cell death process that is crucial for antiviral host defence. RIPK3 self-oligomerization and autophosphorylation are prerequisites for executing necroptosis, yet the underlying mechanism of virus-
Shin-Ae Lee, Lin-Chun Chang, W. Jung, James W. Bowman, Dokyun Kim, Weiqiang Chen, Suan-Sin Foo, Younho Choi, Un Yung Choi, Ann Bowling, Ji-Seung Yoo, Jae U. Jung   +11 more
semanticscholar   +1 more source

Autophagy-Related LC3 Accumulation Interacted Directly With LIR Containing RIPK1 and RIPK3, Stimulating Necroptosis in Hypoxic Cardiomyocytes

Frontiers in Cell and Developmental Biology, 2021
The exact relationships and detailed mechanisms between autophagy and necroptosis remain obscure. Here, we demonstrated the link between accumulated autophagosome and necroptosis by intervening with autophagic flux.
Yao Huang, Yanhai Feng, Lin Cui, Lei Yang, Qiong Zhang, Junhui Zhang, Xupin Jiang, Xingyue Zhang, Yanling Lv, Jie-Zhi Jia, Dong-Xia Zhang, Yue-Sheng Huang, Yue-Sheng Huang   +12 more
doaj   +1 more source

RIPK1 protects from TNF-α-mediated liver damage during hepatitis [PDF]

, 2016
Cell death of hepatocytes is a prominent characteristic in the pathogenesis of liver disease, while hepatolysis is a starting point of inflammation in hepatitis and loss of hepatic function.
Bertin, John, Bertrand, Mathieu, Dimanche-Boitrel, Marie-Thérèse, Farooq, Muhammad, Filliol, Aveline, Genet, Valentine, Gough, Peter J, Le Seyec, Jacques, Lucas-Clerc, Catherine, Piquet-Pellorce, Claire, Samson, Michel, Vandenabeele, Peter   +11 more
core   +1 more source

RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8

Science Advances, 2023
Receptor-interacting protein kinase 1 (RIPK1) regulates cell death and inflammation. Here, we show that T cell–specific RIPK1 deficiency in mice leads to the premature senescence of T cells and induces various age-related diseases, resulting in premature
Takayuki Imanishi, M. Unno, Natsumi Yoneda, Y. Motomura, Miho Mochizuki, Takaharu Sasaki, M. Pasparakis, Takashi Saito   +7 more
semanticscholar   +1 more source

ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis

Cell Death and Differentiation
Z-DNA binding protein 1 (ZBP1) has important functions in anti-viral immunity and in the regulation of inflammatory responses. ZBP1 induces necroptosis by directly engaging and activating RIPK3, however, the mechanisms by which ZBP1 induces inflammation ...
L. Koerner, Laurens Wachsmuth, S. Kumari, Robin Schwarzer, Theresa Wagner, Huipeng Jiao, M. Pasparakis   +6 more
semanticscholar   +1 more source

Role of RIPK3-CaMKII-mPTP signaling pathway-mediated necroptosis in cardiovascular diseases (Review)

International Journal of Molecular Medicine, 2023
Necroptosis, which is distinct from apoptosis and necrosis, serves a crucial role in ontogeny and the maintenance of homeostasis. In the last decade, it has been demonstrated that the pathogenesis of cardiovascular diseases is also linked to necroptosis.
Sheng Chen, Senhong Guan, Zhaohan Yan, Fengshan Ouyang, Shuhuan Li, Lanyuan Liu, Jiankai Zhong   +6 more
semanticscholar   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

RIPK3-Mediated Necroptosis Regulates Cardiac Allograft Rejection

American Journal of Transplantation, 2014
Cell death results in tissue damage and ultimately donor graft rejection and can occur as an active molecular process through apoptotic, necrotic and newly identified receptor interacting protein 1 and 3 kinase (RIPK1/3)-mediated necroptotic pathways. Necroptosis leads to the release of inflammatory molecules which can activate host immune cells.
A, Pavlosky, A, Lau, Y, Su, D, Lian, X, Huang, Z, Yin, A, Haig, A M, Jevnikar, Z-X, Zhang   +8 more
openaire   +2 more sources