Results 21 to 30 of about 246,146 (311)

Long Noncoding RNA Plasmacytoma Variant Translocation 1 Is Increased in Multiple Myeloma and Correlates With Lower Induction Response

Technology in Cancer Research & Treatment, 2020
Objective: This study aimed to investigate the correlation of long noncoding RNA plasmacytoma variant translocation 1 with clinical features and prognosis in patients with multiple myeloma.
Pei Li MD, Xiyao Han MD, Yinghua Xie MM, Yihan Liu MD   +3 more
doaj   +1 more source

Human cancer long non-coding RNA transcriptomes. [PDF]

PLoS ONE, 2011
Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome.
Ewan A Gibb, Emily A Vucic, Katey S S Enfield, Greg L Stewart, Kim M Lonergan, Jennifer Y Kennett, Daiana D Becker-Santos, Calum E MacAulay, Stephen Lam, Carolyn J Brown, Wan L Lam   +10 more
doaj   +1 more source

Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

Nature, 2010
Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome yet their potential involvement in human disease is not well understood.
Rajnish A. Gupta, Nilay Shah, Kevin C. Wang, Jeewon Kim, Hugo M. Horlings, D. Wong, Miao-Chih Tsai, T. Hung, P. Argani, J. Rinn, Yulei N. Wang, P. Brzoska, Benjamin S. Kong, Rui Li, R. West, M. J. van de Vijver, S. Sukumar, Howard Y. Chang   +17 more
semanticscholar   +1 more source

Role of Related Regulatory Long Noncoding RNAs on Mammalian Spermatogenesis

Reproductive and Developmental Medicine, 2017
Long noncoding RNAs (lncRNAs) are transcribed by RNA molecules, which are longer than 200 nucleotides that lack an open reading frame of significant length and possess no obvious protein-coding capacity.
Kang-Sheng Liu, Xiao-Dong Mao, Feng Pan, Ling-Juan Gao, Xiu-Feng Ling   +4 more
doaj   +1 more source

Long noncoding RNA CCAL transferred from fibroblasts by exosomes promotes chemoresistance of colorectal cancer cells

International Journal of Cancer, 2020
Long noncoding RNAs (lncRNAs) are involved in the pathology of colorectal cancer (CRC). Current efforts to eradicate CRC predominantly focused on targeting the proliferation of rapidly growing cancer epithelial cells.
Xuan Deng, Haoyu Ruan, Xin-ju Zhang, Xiao Xu, Yingfeng Zhu, H. Peng, Xiu-Juan Zhang, Fanyang Kong, M. Guan   +8 more
semanticscholar   +1 more source

The Regulatory Activity of Noncoding RNAs in ILCs

Cells, 2021
Innate lymphoid cells (ILCs) are innate lymphocytes playing essential functions in protection against microbial infections and participate in both homeostatic and pathological contexts, including tissue remodeling, cancer, and inflammatory disorders.
Alessio Grimaldi, Giuseppe Pietropaolo, Helena Stabile, Andrea Kosta, Cristina Capuano, Angela Gismondi, Angela Santoni, Giuseppe Sciumè, Cinzia Fionda   +8 more
doaj   +1 more source

The multidimensional mechanisms of long noncoding RNA function

Genome Biology, 2017
A major shift in our understanding of genome regulation has emerged recently. It is now apparent that the majority of cellular transcripts do not code for proteins, and many of them are long noncoding RNAs (lncRNAs).
Francesco P. Marchese, Ivan Raimondi, Maite Huarte   +2 more
semanticscholar   +1 more source

Cytokines and Long Noncoding RNAs [PDF]

Cold Spring Harbor Perspectives in Biology, 2017
Cytokines and long noncoding RNAs (lncRNAs) are intertwined in the regulatory circuit controlling immunity. lncRNA expression levels are altered following cytokine stimulation in a cell-type-specific fashion. lncRNAs, in turn, regulate the inducible expression of cytokines following immune activation.
Susan, Carpenter, Katherine A, Fitzgerald   +1 more
openaire   +2 more sources

Integrated Profiling Revealed Potential Regulatory Networks Among Long Noncoding RNAs and mRNAs in Mucosal Gastric Cancer

Technology in Cancer Research & Treatment, 2020
Gastric cancer is one of the most commonly occurring cancers worldwide. Investigation of long noncoding RNAs is of increasing interest, particularly in relation to their contribution to progression and prognosis of gastric cancers; however, insufficient ...
Ke-kang Sun MD, Xiao-jun Shen MM, Dong Yang MM, Yang Jiao PhD, Xiao-yang Wu PhD   +4 more
doaj   +1 more source

Transcriptional network modulated by the prognostic signature transcription factors and their long noncoding RNA partners in primary prostate cancer

EBioMedicine, 2021
Background: Transcriptional regulators are seminal players in the onset and progression of prostate cancer. However, clarification of their underlying regulatory circuits and mechanisms demands considerable effort.
Mei Jiang, Yihang Cheng, Dan Wang, Yali Lu, Shaohua Gu, Chenji Wang, Yan Huang, Yao Li   +7 more
doaj   +1 more source