Results 31 to 40 of about 246,146 (311)

Long Noncoding RNA (lncRNA)-Mediated Competing Endogenous RNA Networks Provide Novel Potential Biomarkers and Therapeutic Targets for Colorectal Cancer

International Journal of Molecular Sciences, 2019
Colorectal cancer (CRC) is the third most common cancer and has a high metastasis and reoccurrence rate. Long noncoding RNAs (lncRNAs) play an important role in CRC growth and metastasis.
Liye Wang, Kwang Bog Cho, Yan Li, Gabriel Tao, Zuoxu Xie, Bin Guo   +5 more
semanticscholar   +1 more source

Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming

Nature Communications, 2020
Tumor cells often reprogram their metabolism for rapid proliferation. The roles of long noncoding RNAs (lncRNAs) in metabolism remodeling and the underlying mechanisms remain elusive.
Jia Liu, Ze-xian Liu, Qi-Nian Wu, Yun-xin Lu, Chau-Wei Wong, Lei Miao, Yun Wang, Zixian Wang, Ying Jin, M. He, C. Ren, Deshen Wang, Dong‐Liang Chen, Heng-Ying Pu, Lin Feng, Bo Li, D. Xie, M. Zeng, Peng Huang, Aifu Lin, D. Lin, R. Xu, Huai-qiang Ju   +22 more
semanticscholar   +1 more source

Long noncoding RNAs regulate adipogenesis [PDF]

Proceedings of the National Academy of Sciences, 2013
The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, but the global expression patterns and functional contributions of long noncoding RNA (lncRNA) during adipogenesis have not ...
Sun, Lei, Goff, Loyal, Trapnell, Cole, Alexander, Ryan, Lo, Kinyui Alice, Hacisuleyman, Ezgi, Sauvageau, Martin, Tazon-Vega, Barbara, Kelley, David Roy, Hendrickson, David Gillis, Yuan, Bingbing, Kellis, Manolis, Lodish, Harvey F., Rinn, John   +13 more
openaire   +3 more sources

Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

Cell Death and Differentiation, 2019
The regulatory loop between long noncoding RNAs (lncRNAs) and microRNAs has a dynamic role in transcriptional and translational regulation, and is involved in cancer.
Min Wang, Chao Mao, Lianlian Ouyang, Yating Liu, Weiwei Lai, Na Liu, Ying Shi, Ling Chen, D. Xiao, F. Yu, Xiang Wang, Hu Zhou, Ya Cao, Shuang Liu, Q. Yan, Y. Tao, Bin Zhang   +16 more
semanticscholar   +1 more source

p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis.

Molecules and Cells, 2020
The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Here, we identify Pvt1b,
Christiane E. Olivero, Elena Martínez-Terroba, Joshua T. Zimmer, Clara Liao, Ephrath Tesfaye, Nima Hooshdaran, Jeremy A. Schofield, Jordan Bendor, Dorthy Fang, M. Simon, Jesse R Zamudio, N. Dimitrova   +11 more
semanticscholar   +1 more source

Long noncoding RNAs in hematopoiesis [PDF]

F1000Research, 2016
Mammalian development is under tight control to ensure precise gene expression. Recent studies reveal a new layer of regulation of gene expression mediated by long noncoding RNAs. These transcripts are longer than 200nt that do not have functional protein coding capacity.
Zhang, Xu, Hu, Wenqian
openaire   +2 more sources

Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3

Molecular Cancer, 2019
YAP activation is crucial for cancer development including colorectal cancer (CRC). Nevertheless, it remains unclear whether N6-Methyladenosine (m6A) modified transcripts of long noncoding RNAs (lncRNAs) can regulate YAP activation in cancer progression.
Wen Ni, Su Yao, Yunxia Zhou, Yuan-yuan Liu, Piao Huang, Ai-jun Zhou, Jingwen Liu, Li-Heng Che, Jian-Ming Li   +8 more
semanticscholar   +1 more source

Long noncoding RNA MALAT1 and Regulation of the Antioxidant Defense System in Diabetic Retinopathy.

Diabetes, 2020
Retina experiences increased oxidative stress in diabetes, and the transcriptional activity of Nrf2, critical in regulating many antioxidant genes, is decreased. Nuclear movement-transcriptional activity of Nrf2 is mediated by its intracellular inhibitor
R. Radhakrishnan, R. Kowluru
semanticscholar   +1 more source

Long noncoding RNA and protein abundance in lncRNPs

RNA: A publication of the RNA Society, 2021
Although long noncoding RNAs (lncRNAs) are generally expressed at low levels, emerging evidence has revealed that many play important roles in gene regulation by a variety of mechanisms as they engage with proteins.
Man Wu, Liang-Zhong Yang, Ling-Ling Chen
semanticscholar   +1 more source

Panning for Long Noncoding RNAs [PDF]

Biomolecules, 2013
The recent advent of high-throughput approaches has revealed widespread transcription of the human genome, leading to a new appreciation of transcription regulation, especially from noncoding regions. Distinct from most coding and small noncoding RNAs, long noncoding RNAs (lncRNAs) are generally expressed at low levels, are less conserved and lack ...
Li Yang, Xiao-Ou Zhang, Shanshan Zhu
openaire   +3 more sources