Results 41 to 50 of about 246,146 (311)
Long Noncoding RNAs in Metabolic Syndrome Related Disorders
Mediators of Inflammation, 2016 Ribonucleic acids (RNAs) are very complex and their all functions have yet to be fully clarified. Noncoding genes (noncoding RNA, sequences, and pseudogenes) comprise 67% of all genes and they are represented by housekeeping noncoding RNAs (transfer RNA (
Magdalena Losko +2 more
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Review: Long non-coding RNA in livestock
Animal, 2020 Less than 2% of mammalian genomes code for proteins, but ‘the majority of its bases can be found in primary transcripts’ – a phenomenon termed the pervasive transcription, which was first reported in 2007.
B. Kosinska-Selbi +2 more
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Immunobiology of Long Noncoding RNAs [PDF]
Annual Review of Immunology, 2017 The discovery of long noncoding RNAs (lncRNA) has provided a new perspective on gene regulation in diverse biological contexts. lncRNAs are remarkably versatile molecules that interact with RNA, DNA, or proteins to promote or restrain the expression of protein-coding genes. Activation of immune cells is associated with dynamic changes in expression of
Atianand, Maninjay K. +2 more
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Long non-coding RNA and diseases [PDF]
Jichu yixue yu linchuangLong non-coding RNA (lncRNA) is a class of endogenous non-coding RNA with a length of more than 200 nt. Due to lack of open reading frame (ORF), they lack the ability to directly encode proteins, but they play a crucial role in gene regulation.
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Mechanisms of long noncoding RNA function in development and disease
Cellular and Molecular Life Sciences, 2016 Since decades it has been known that non-protein-coding RNAs have important cellular functions. Deep sequencing recently facilitated the discovery of thousands of novel transcripts, now classified as long noncoding RNAs (lncRNAs), in many vertebrate and ...
Sandra U. Schmitz +2 more
semanticscholar +1 more source
Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473
Nature Metabolism, 2020 Human thermogenic adipose tissue mitigates metabolic disease, thus raising much interest in understanding its development and function. Here, we show that human thermogenic adipocytes specifically express a primate-specific long noncoding RNA (lncRNA ...
Khanh-Van Tran +23 more
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MALAT1 Long Non-Coding RNA: Functional Implications
Non-Coding RNA, 2020 The mammalian genome is pervasively transcribed and the functional significance of many long non-coding RNA (lncRNA) transcripts are gradually being elucidated.
Gayatri Arun +2 more
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Non-Coding RNA, 2022 Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year ...
Adrienne Vancura +6 more
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NONCODE v3.0: integrative annotation of long noncoding RNAs [PDF]
Nucleic Acids Research, 2011 Facilitated by the rapid progress of high-throughput sequencing technology, a large number of long noncoding RNAs (lncRNAs) have been identified in mammalian transcriptomes over the past few years. LncRNAs have been shown to play key roles in various biological processes such as imprinting control, circuitry controlling pluripotency and differentiation,
Bu, Dechao +14 more
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Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer.
Journal of Clinical Investigation, 2019 Patients with bladder cancer (BCa) with clinical lymph node (LN) metastasis have extremely poor prognosis. VEGF-C has been demonstrated to play vital roles in LN metastasis in BCa.
Changhao Chen +11 more
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