Results 11 to 20 of about 549,357 (248)

Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations [PDF]

Nature Communications
Expansion of RNA polymerase III (Pol III) activity in cancer can activate the transcription of typically silent small RNA genes, including snaR-A (small NF90-associated RNA isoform A), a hominid-specific noncoding RNA that promotes cell proliferation ...
Sihang Zhou, Simon Lizarazo, Sandip Chorghade, Leela Mouli, Ruiying Cheng, Rajendra K C, Auinash Kalsotra, Kevin Van Bortle   +7 more
doaj   +2 more sources

U2.3 Precursor Small Nuclear RNA in vitro Processing Assay

Bio-Protocol, 2021
Small nuclear RNAs (snRNAs) are vital for eukaryotic cell activities and play important roles in pre-mRNA splicing. The molecular mechanism underlying the transcription of snRNA, regulated via upstream/downstream cis-elements and relevant trans-elements,
Chan Lin, Yujie Feng, Xueyan Peng, Jiaming Wu, Weili Wang, Yunfeng Liu   +5 more
doaj   +1 more source

The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing

Cell Reports, 2023
Summary: Argonaute/small RNA pathways and heterochromatin work together to propagate transgenerational gene silencing, but the mechanisms behind their interaction are not well understood.
Yue-He Ding, Humberto J. Ochoa, Takao Ishidate, Masaki Shirayama, Craig C. Mello   +4 more
doaj   +1 more source

Small RNA signatures of the anterior cruciate ligament from patients with knee joint osteoarthritis

Frontiers in Molecular Biosciences, 2023
Introduction: The anterior cruciate ligament (ACL) is susceptible to degeneration, resulting in joint pain, reduced mobility, and osteoarthritis development.
Yalda A. Kharaz, Danae E. Zamboulis, Yongxiang Fang, Tim J. M. Welting, Mandy J. Peffers, Eithne J. Comerford, Eithne J. Comerford   +6 more
doaj   +1 more source

Identification of small RNA in polyhedra of Bombyx mori nuclear polyhedrosis virus [PDF]

The Ukrainian Biochemical Journal, 2014
It has been shown by bioinformatic methods­ that regions of the Bombyx mori viral nuclear poly­hedrosis genome encoded two small RNA – snc RNA-1 and snc RNA-2, which could perform a structural function in polyhedra crystals formation.
T. V. Shirina, G. V. Gerashchenko, M. T. Bobrovskaja, V. I. Kashuba   +3 more
doaj   +1 more source

High Throughput FISH Screening Identifies Small Molecules That Modulate Oncogenic lncRNA MALAT1 via GSK3B and hnRNPs

Non-Coding RNA, 2023
Traditionally, small molecule-based drug discovery has mainly focused on proteins as the drug target. Opening RNA as an additional target space for small molecules offers the possibility to therapeutically modulate disease-driving non-coding RNA targets ...
Nina Zablowsky, Lydia Farack, Sven Rofall, Jan Kramer, Hanna Meyer, Duy Nguyen, Alexander K. C. Ulrich, Benjamin Bader, Patrick Steigemann   +8 more
doaj   +1 more source

The epitranscriptome of small non-coding RNAs

Non-coding RNA Research, 2021
Small non-coding RNAs are short RNA molecules and involved in many biological processes, including cell proliferation and differentiation, immune response, cell death, epigenetic regulation, metabolic control.
Xiaoyu Li, Jinying Peng, Chengqi Yi
doaj   +1 more source

Small RNA sequencing reveals distinct nuclear microRNAs in pig granulosa cells during ovarian follicle growth

Journal of Ovarian Research, 2021
Nuclear small RNAs have emerged as an important subset of non-coding RNA species that are capable of regulating gene expression. A type of small RNA, microRNA (miRNA) have been shown to regulate development of the ovarian follicle via canonical targeting
Derek Toms, Bo Pan, Yinshan Bai, Julang Li   +3 more
doaj   +1 more source

PARN and TOE1 Constitute a 3′ End Maturation Module for Nuclear Non-coding RNAs

Cell Reports, 2018
Summary: Poly(A)-specific ribonuclease (PARN) and target of EGR1 protein 1 (TOE1) are nuclear granule-associated deadenylases, whose mutations are linked to multiple human diseases.
Ahyeon Son, Jong-Eun Park, V. Narry Kim
doaj   +1 more source

RNAi Factors Are Present and Active in Human Cell Nuclei

Cell Reports, 2014
RNAi is widely appreciated as a powerful regulator of mRNA translation in the cytoplasm of mammalian cells. However, the presence and activity of RNAi factors in the mammalian nucleus has been the subject of considerable debate.
Keith T. Gagnon, Liande Li, Yongjun Chu, Bethany A. Janowski, David R. Corey   +4 more
doaj   +1 more source