Normal human placentas contain RNA-directed DNA polymerase activity like that in viruses. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1978 Extracts from over 100 normal human placentas have been examined for RNA-directed DNA polymerase (DNA nucleotidyltransferase, EC 2.7.7.7) activity. More than 80% of these placentas contained this enzyme activity, which banded at a density of 1.15-1.17 g ...
Jay A. Nelson, J A Leong, Jay A. Levy
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Relationship Between RNA-directed DNA Polymerase (Reverse Transcriptase) from Human Acute Leukemic Blood Cells and Primate Type-C Viruses [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1974 An RNA-directed DNA polymerase was isolated from the peripheral blood leukocytes of a patient with acute myelomonocytic leukemia by successive purification of a particulate cytoplasmic fraction with endogenous, ribonuclease-sensitive DNA polymerase ...
Robert E. Gallagher +4 more
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A Single Subunit from Avian Myeloblastosis Virus with Both RNA-Directed DNA Polymerase and Ribonuclease H Activity [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1973 Two structurally distinct forms of RNA-directed DNA polymerase from avian myeloblastosis virus were resolved by chromatography on phosphocellulose and purified. In addition to RNA-directed DNA polymerase activity, both enzymes had ribonuclease H (RNase H)
Duane P. Grandgenett +2 more
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PLoS Genetics, 2020 RNA-directed DNA methylation (RdDM) is a biological process in which non-coding RNA molecules direct the addition of DNA methylation to specific DNA sequences.
Robert M Erdmann, Colette L Picard
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RNA-Directed DNA Polymerase and Virus-Induced Leukemia in Mice [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1973 Rifamycin antibiotics, which inhibit RNA-directed DNA polymerase of Rauscher leuckemia virus, prevent the leukemogenic activity of the virus, and the effect of leukemogenesis correlates with the magnitude of inhibition of the purified enzyme.
Alan M. Wu +2 more
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Arabidopsis RNA Polymerase IV generates 21-22 nucleotide small RNAs that can participate in RNA-directed DNA methylation and may regulate genes [PDF]
bioRxiv, 2019 The plant-specific RNA Polymerase IV (Pol IV) transcribes heterochromatic regions, including many transposable elements, with the well-described role of generating 24 nucleotide (nt) small interfering RNAs (siRNAs).
Kaushik Panda +2 more
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RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis. [PDF]
Nature Plants, 2018 Small RNAs regulate chromatin modifications such as DNA methylation and gene silencing across eukaryotic genomes. In plants, RNA-directed DNA methylation (RdDM) requires 24-nucleotide small interfering RNAs (siRNAs) that bind to ARGONAUTE 4 (AGO4) and ...
Chory, Joanne +11 more
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Particles with RNA of High Molecular Weight and RNA-Directed DNA Polymerase in Human Brain Tumors
Proceedings of the National Academy of Sciences of the United States of America, 1973 We have previously shown that neoplastic cells of human breast cancers, leukemias, lymphomas, and sarcomas contain particles similar to the viruses that have been established as etiologic agents of these diseases in mice.
W. Cuatico, J.-R. Cho, S. Spiegelman
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Extent of Transcription of Mouse Sarcoma-Leukemia Virus by RNA-Directed DNA Polymerase [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1974 The DNA product obtained from the endogenous RNA-directed DNA polymerase (deoxynucleosidetriphosphate:DNA deoxynucleotidyltransferase, EC 2.7.7.7) reaction of the Moloney sarcoma:leukemia viruses produced by the 78 A-1 cell line was analyzed and ...
A Tavitian +4 more
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Human placentas contain a specific inhibitor of RNA-directed DNA polymerase. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1981 Human placental extracts contain a specific inhibitor of mammalian retroviral RNA-directed DNA polymerase (deoxynucleosidetriphosphate:DNA deoxynucleotidyltransferase, EC 2.7.7.7) activity.
Jay A. Nelson +2 more
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