Results 31 to 40 of about 238,840 (242)
Frontiers in Pharmacology, 2022 N6-methyladenosine (m6A) RNA methylation has been considered the most prevalent, abundant, and conserved internal transcriptional modification throughout the eukaryotic mRNAs.
Zhaolin Chen +7 more
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RNA Splicing Factors and RNA-Directed DNA Methylation [PDF]
Biology, 2014 RNA-directed histone and/or DNA modification is a conserved mechanism for the establishment of epigenetic marks from yeasts and plants to mammals. The heterochromation formation in yeast is mediated by RNAi-directed silencing mechanism, while the establishment of DNA methylation in plants is through the RNA-directed DNA methylation (RdDM) pathway ...
Chao-Feng Huang, Jian-Kang Zhu
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Detecting m6A methylation regions from Methylated RNA Immunoprecipitation Sequencing
Bioinformatics, 2021 AbstractMotivationThe post-transcriptional epigenetic modification on mRNA is an emerging field to study the gene regulatory mechanism and their association with diseases. Recently developed high-throughput sequencing technology named Methylated RNA Immunoprecipitation Sequencing (MeRIP-seq) enables one to profile mRNA epigenetic modification ...
Zhenxing Guo +4 more
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Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain [PDF]
Open Biology, 2017 N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark found on mRNA and has important roles in various physiological processes. Despite the relatively high m6A levels in the brain, its potential functions in the brain remain largely ...
Mengqi Chang +10 more
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RNA Methylation in Systemic Lupus Erythematosus
Frontiers in Cell and Developmental Biology, 2021 Systemic lupus erythematosus (SLE) is an autoimmune disease with complicated clinical manifestations. Although our understanding of the pathogenesis of SLE has greatly improved, the understanding of the pathogenic mechanisms of SLE is still limited by ...
Xinyi Lv +6 more
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Reading RNA methylation codes through methyl-specific binding proteins [PDF]
RNA Biology, 2014 N (6)-methyladenosine (m (6)A) is a prevalent modification of eukaryotic mRNAs. It regulates yeast cell fate and is essential to the development and fertility of metazoans. Although its presence in mRNA has been known since the early 1970s, the function of m (6)A remained a mystery until the spate of discoveries in the past three years.
Xiao, Wang, Chuan, He
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The role of mRNA m6A methylation in the nervous system
Cell & Bioscience, 2019 Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (
Jiashuo Li +8 more
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The potential regulatory role of RNA methylation in ovarian cancer
RNA Biology, 2023 Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao +5 more
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Multiple functions of m6A RNA methylation in cancer
Journal of Hematology & Oncology, 2018 First identified in 1974, m6A RNA methylation, which serves as a predominant internal modification of RNA in higher eukaryotes, has gained prodigious interest in recent years. Modifications of m6A are dynamic and reversible in mammalian cells, which have
Yutian Pan +4 more
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Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop
Journal of Ginseng Research, 2021 Background: The underlying mechanisms of the potential tumor-suppressive effects of ginsenoside Rh2 are complex. N6-methyladenosine (m6A) RNA methylation is usually dysregulated in cancer.
Chunmei Hu +5 more
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