Results 121 to 130 of about 564,596 (305)

RNA Modifications: Current Understandings and Future Perspectives

MedComm
RNA modification has been established as a pivotal field in epitranscriptomics, representing an emerging, dynamic, and precise regulatory layer in gene expression control.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
doaj   +1 more source

Translational Recoding and RNA Modifications

, 2005
During protein synthesis, codons in mRNA are translated sequentially in frame on the ribosome following strict decoding rules. This process is usually very accurate. However, in some cases, recoding events occur at selected codons, leading to a high frequency of frameshifting or stop codon readthrough.
Namy, Olivier, Lecointe, François, Grosjean, Henri, Rousset, Jean-Pierre   +3 more
openaire   +3 more sources

Genetic modification of Bluetongue virus by uptake of "synthetic" genome segments [PDF]

, 2010
Since 1998, several serotypes of Bluetongue virus (BTV) have invaded several southern European countries. In 2006, the unknown BTV serotype 8 (BTV8/net06) unexpectedly invaded North-West Europe and has resulted in the largest BT-outbreak ever recorded ...
Veldman, D., van de Water, S.G.P., René GP van Gennip, van de Water Sandra GP, Veldman Daniel, Piet A van Rijn, Rijn, P.A., van, Daniel Veldman, van Gennip, H.G.P., Gennip, H.G.P., van, van Gennip René GP, van Rijn Piet A, Water, S.G.P., van de, Sandra GP van de Water, van Rijn, P.A.   +14 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Analysis of RNA and Its Modifications

Annual Review of Analytical Chemistry
Ribonucleic acids (RNAs) are key biomolecules responsible for the transmission of genetic information, the synthesis of proteins, and modulation of many biochemical processes. They are also often the key components of viruses. Synthetic RNAs or oligoribonucleotides are becoming more widely used as therapeutics.
Cassandra, Herbert, Satenik, Valesyan, Jennifer, Kist, Patrick A, Limbach   +3 more
openaire   +2 more sources

RNA modification in Cajal bodies [PDF]

RNA Biology, 2016
Aside from nucleoli, Cajal bodies (CBs) are the best-characterized organelles of mammalian cell nuclei. Like nucleoli, CBs concentrate ribonucleoproteins (RNPs), in particular, spliceosomal small nuclear RNPs (snRNPs) and small nucleolar RNPs (snoRNPs).
openaire   +2 more sources

Stress-Induced PARP Activation Mediates Recruitment of Drosophila Mi-2 to Promote Heat Shock Gene Expression [PDF]

, 2011
Eukaryotic cells respond to genomic and environmental stresses, such as DNA damage and heat shock (HS), with the synthesis of poly-ADP-ribose] (PAR) at specific chromatin regions, such as DNA breaks or HS genes, by PAR polymerases (PARP). Little is known
Renate Renkawitz-Pohl, Hassler Markus, Murawska, Magdalena, Ladurner Andreas, Brehm Alexander, Andreas Ladurner, Renkawitz-Pohl, Renate, Brehm, Alexander, Ladurner, Andreas, Magdalena Murawska, Murawska Magdalena, Markus Hassler, Hassler, Markus, Alexander Brehm, Renkawitz-Pohl Renate   +14 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

DNA N6-Methyladenosine modification role in transmitted variations from genomic DNA to RNA in Herrania umbratica

BMC Genomics, 2019
Background DNA methylation is an important epigenetic modification. Recently the developed single-molecule real-time (SMRT) sequencing technology provided an efficient way to detect DNA N6-methyladenine (6mA) modification that played an important role in
Mei-Wei Luan, Wei Chen, Jian-Feng Xing, Chuan-Le Xiao, Ying Chen, Shang-Qian Xie   +5 more
doaj   +1 more source

Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8

, 2009
The U5 snRNA loop 1 aligns the 5' and 3' exons for ligation during the second step of pre-mRNA splicing. U5 is intimately associated with Prp8, which mediates pre-mRNA repositioning within the catalytic core of the spliceosome and interacts directly with
David Barrass, J., Kershaw, Christopher J., O'Keefe, Raymond T., Barrass, J. David, Beggs, Jean D., O'Keefe, Raymond T.; id_orcid   +5 more
core   +1 more source