Results 111 to 120 of about 798,047 (345)

Self-organized critical dynamics of RNA virus evolution [PDF]

arXiv, 2022
RNA virus (e.g., SARS-CoV-2) evolves in a complex manner. Studying RNA virus evolution is vital for understanding molecular evolution and medicine development. Scientists lack, however, general frameworks to characterize the dynamics of RNA virus evolution directly from empirical data and identify potential physical laws. To fill this gap, we present a
arxiv  

A Database for TSSs of Human MicroRNAs [PDF]

, 2012
MicroRNAs (miRNAs) are small endogeneous non-coding RNAs of about 22nt length. These short RNAs regulate the expression of mRNAs by hybridizing with their 3'-UTRs or by translational repression.
Malay Bhattacharyya, Sanghamitra Bandyopadhyay   +1 more
core   +2 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Nascent-Seq reveals novel features of mouse circadian transcriptional regulation

eLife, 2012
A substantial fraction of the metazoan transcriptome undergoes circadian oscillations in many cells and tissues. Based on the transcription feedback loops important for circadian timekeeping, it is commonly assumed that this mRNA cycling reflects ...
Jerome S Menet, Joseph Rodriguez, Katharine C Abruzzi, Michael Rosbash   +3 more
doaj   +1 more source

Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetes. [PDF]

PLoS ONE, 2013
Dysregulation of circadian rhythmicity is identified as a key factor in disease pathogenesis. Circadian rhythmicity is controlled at both a transcriptional and post-transcriptional level suggesting the role of microRNA (miRNA) and double-stranded RNA ...
Yuanqing Yan, Tatiana E Salazar, James M Dominguez, Dung V Nguyen, Sergio Li Calzi, Ashay D Bhatwadekar, Xiaoping Qi, Julia V Busik, Michael E Boulton, Maria B Grant   +9 more
doaj   +1 more source

An Ansatz for computational undecidability in RNA automata [PDF]

arXiv, 2020
In this Ansatz we consider theoretical constructions of RNA polymers into automata, a form of computational structure. The basis for transitions in our automata are plausible RNA enzymes that may perform ligation or cleavage. Limited to these operations, we construct RNA automata of increasing complexity; from the Finite Automaton (RNA-FA) to the ...
arxiv  

Uncovering the effect of RNA polymerase steric interactions on gene expression noise: analytical distributions of nascent and mature RNA numbers [PDF]

arXiv, 2023
The telegraph model is the standard model of stochastic gene expression, which can be solved exactly to obtain the distribution of mature RNA numbers per cell. A modification of this model also leads to an analytical distribution of the nascent RNA numbers. These solutions are routinely used for the analysis of single-cell data, including the inference
arxiv  

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

The critical role of RNA processing and degradation in the control of gene expression.

FEMS Microbiology Reviews, 2010
The continuous degradation and synthesis of prokaryotic mRNAs not only give rise to the metabolic changes that are required as cells grow and divide but also rapid adaptation to new environmental conditions.
C. Arraiano, J. M. Andrade, S. Domingues, I. Guinote, M. Malecki, R. Matos, R. N. Moreira, V. Pobre, Filipa P. Reis, M. Saramago, I. J. Silva, S. C. Viegas   +11 more
semanticscholar   +1 more source

Genome wide comparative analysis of the effects of PRMT5 and PRMT4/CARM1 arginine methyltransferases on the Arabidopsis thaliana transcriptome [PDF]

, 2015
BACKGROUND: Methylation at arginine residues (R) is an important post-translational modification that regulates a myriad of essential cellular processes in eukaryotes, such as transcriptional regulation, RNA processing, signal transduction and DNA repair.
Hernando, Carlos Esteban, Mancini, Estefania, Sanchez, Sabrina Elena, Yanovsky, Marcelo Javier   +3 more
core   +1 more source